Esmolol Attenuates Hemodynamic Responses during Fentanyl-Pancuronium Anesthesia for Aortocoronary Bypass Surgery

Newsome, Lars R.; Roth, Jonathan V.; Hug, Carl C.; Nagle, David

doi:10.1213/00000539-198605000-00004

Cited by 43 publications

(14 citation statements)

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“…Esmolol has been used successfully for hypertension in the perioperative period (Cucchiara et al 1986; Girard et al 1986; Newsome et al 1986; Gray et al 1987; Gibson et al 1988). The metabolism of esmolol is via rapid hydrolysis of ester linkages by red blood cell (RBC) esterases and is not dependant on renal or hepatic function.…”

Section: Pharmacotherapymentioning

confidence: 99%

Perioperative hypertension management

Varon¹

2008

VHRM

159

117

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Perioperative hypertension is commonly encountered in patients that undergo surgery. While attempts have been made to standardize the method to characterize the intraoperative hemodynamics, these methods still vary widely. In addition, there is a lack of consensus concerning treatment thresholds and appropriate therapeutic targets, making absolute recommendations about treatment diffi cult. Nevertheless, perioperative hypertension requires careful management. When treatment is necessary, therapy should be individualized for the patient. This paper reviews the pharmacologic agents and strategies commonly used in the management of perioperative hypertension.

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Section: Pharmacotherapymentioning

confidence: 99%

Perioperative hypertension management

Varon¹

2008

VHRM

159

117

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“…9 Newsome LR demonstrated that esmolol was effective in attenuating the haemodynamic responses during anaesthesia. 10 Sheppard et al (1990) observed that Esmolol 200 mg was effective in attenuating the pressor response to intubation after tracheal intubation. 7 Oxorn et al commented that hypotension on induction was observed with higher doses of esmolol.…”

Section: Discussionmentioning

confidence: 99%

SUPPRESSION OF PRESSOR RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION BY ESMOLOL ADMINISTERED IN DOSES OF 1.5 mg/kg, 2.25 mg/kg: A COMPARATIVE CLINICAL STUDY

Hatti¹,

Patil²

2016

jemds

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“…It is well known that children mainly depend on speeding up heart rate to raise cardiac output, esmolol could lower the heart rate, so it would inevitably decrease cardiac output, sufficient cardiac output is a prerequisite for maintaining tissue oxygen supply; therefore, the optimal therapeutic dosage of esmolol during open heart surgery in children is worthy of being studied. Esmolol continuous infusion rate during CPB is between 0.1 and 0.3 mgÁkg À1 Ámin À1 in many studies (4,5,(11)(12)(13)(14). In the present study, esmolol continuous infusion rate during CPB was 0.3 mgÁkg À1 Ámin À1 .…”

Section: Discussionmentioning

confidence: 99%

Protective effect of esmolol on myocardial ischemic injury during open heart surgery in children

Gui

et al. 2013

Pediatric Anesthesia

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SummaryObjectives: To investigate the efficacy of esmolol in protecting the myocardium from ischemia during pediatric cardiac surgery. Background: Esmolol, an ultra-short acting beta 1-adrenoceptor blocker, reduces myocardial injury in adult cardiac operations. However, this technique is rarely used in pediatric cardiac surgery. Methods: Thirty children with ventricular septal defect were randomly allocated to the esmolol group and the control group. Patients received intravenous esmolol (0.05 mgÁkg À1 ÁminÀ1 after tracheal intubation, 0.3 mgÁkg À1 Ámin À1 during cardiopulmonary bypass (CPB) and 0.03-0.05 mgÁkg À1 Ámin À1 until the end of surgery) or placebo, respectively. Results: Plasma levels of creatine kinase-MB, cardiac troponin I in the esmolol group 2 min after completion of CPB, at the end of surgery, 4 h after surgery, and the first postoperative day were significantly lower than those in the control group. Values of heart rate 10 min after induction, 2 min before institution of CPB, 2 min after completion of CPB, and at the end of surgery were significantly lower in the esmolol group; however, mean arterial pressure, CPB time, cross-clamp time, and the rate of heart spontaneous rebeating were not statistically different between two groups. Cumulative postoperative dosage of dopamine in the esmolol group (100.1 AE 53.1 mg) was significantly less than that in the control group (171.4 AE 92.1 mg). Conclusions: Esmolol can protect the myocardium from ischemic injury during CPB in children and significantly reduce the use of inotropic drug.

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Esmolol Attenuates Hemodynamic Responses during Fentanyl-Pancuronium Anesthesia for Aortocoronary Bypass Surgery

Cited by 43 publications

References 0 publications

Perioperative hypertension management

Perioperative hypertension management

SUPPRESSION OF PRESSOR RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION BY ESMOLOL ADMINISTERED IN DOSES OF 1.5 mg/kg, 2.25 mg/kg: A COMPARATIVE CLINICAL STUDY

Protective effect of esmolol on myocardial ischemic injury during open heart surgery in children

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