Estimation of lipid peroxides and antioxidants in smokers and non-smokers with periodontitis

Reejamol, M K; Swaminathan, Mythili

doi:10.1016/j.ksujds.2013.05.001

Cited by 7 publications

(7 citation statements)

References 17 publications

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“…Enzymes may take form of free radicals scavengers such as CAT, SOD, and GXp in smokers the obligatory use of reserve antioxidant to detoxify the excess free radicals, result in alternation of the levels of different antioxidants enzymes [43]. We have demonstrated the activity of CAT was significantly lowering in smokers than nonsmokers and this result may be due to structural features of CAT or environmental factors, increased of SOD and GXp levels were occurred as a result of increase lipid peroxidation [44].…”

Section: Antioxidant Enzymesmentioning

confidence: 71%

Smoking Effects on Blood Antioxidants Level: Lactate Dehydrogenase, Catalase, Superoxide Dismutase and Glutathione Peroxidase in University Students

Raddam¹,

Zeidan²,

Asaad³

et al. 2017

J Clin Exp Pathol

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Smoking has been involved as a significant risk factor for series and establishment of diseases. The aim of our study to investigate smoking effects induced oxidative damage. We have chosen male students of Al-Iraqia University and Tikrit University, aged 20-23 years. In our study we measured activity of Lactate Dehydrogenase (LDH), Catalase (CAT), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GXp). Our results showing that the level of LDH in smokers were higher than nonsmokers ,and the levels of CAT was higher in group of nonsmokers ,while SOD and GXp were higher significantly in non-smokers when comparison with smoker students. Also we study the height, body weight, body mass index (BMI), and some of blood parameters red blood cells (RBCs), White blood cells (WBCs), and hemoglobin (Hb). Results showing significant differences between smokers and nonsmokers, all of these parameters were lower in smokers. These results perhaps indicate that smoker students have oxidative stress and shortness in antioxidants defense system.

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Section: Antioxidant Enzymesmentioning

confidence: 71%

Smoking Effects on Blood Antioxidants Level: Lactate Dehydrogenase, Catalase, Superoxide Dismutase and Glutathione Peroxidase in University Students

Raddam¹,

Zeidan²,

Asaad³

et al. 2017

J Clin Exp Pathol

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“…(7) The gaseous and particulate components of cigarette smoke are potential inducers of free radicals. (3,8) The results of a study showed the presence of free radicals in periodontal tissues of smokers. (8) The results of another study in rats showed that exposure to cigarettes, whether electronic or conventional, can disturb rat spermatogenesis through an increase in free radicals.…”

Section: Introductionmentioning

confidence: 99%

“…(3,8) The results of a study showed the presence of free radicals in periodontal tissues of smokers. (8) The results of another study in rats showed that exposure to cigarettes, whether electronic or conventional, can disturb rat spermatogenesis through an increase in free radicals. (9) Free radicals are extremely reactive compounds and thus easily react with other compounds such as lipids, DNA and proteins.…”

Section: Introductionmentioning

confidence: 99%

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Smoking tends to decrease glutathione and increase malondialdehyde levels in medical students

Safyudin

Subandrate

2016

UnivMed

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Background Smoking is the act of introducing toxic substances into the body. Cigarette smoke contains chemicals that may cause several disorders, including cardiovascular disease, cancer, and chronic obstructive pulmonary disease. Toxic substances in cigarette smoke have the potential to increase free radicals, malondialdehyde (MDA) levels and to decrease endogenous antioxidant (glutathione/GSH) levels. This study aims to determine the relationship of smoking with plasma GSH and MDA levels in medical students. Methods This study was analytical observational with cross-sectional approach. The study was conducted from April to December 2015. The subjects in this study were medical students, consisting of 20 smokers and 20 nonsmokers. Plasma GSH and MDA levels were determined biochemically using Sigma GSH Assay Kit and Sigma MDA Assay Kit. Data was analyzed using the independent t test. Results The results showed that there was no significant difference between mean GSH in smokers (1.74 ± 0.91 mmol/L) and nonsmokers (2.42 ± 1.19 µmol/L) (p=0.441). Mean smokers MDA level of 2.06 ± 1.39 nmol/mL was not significantly different compared with mean nonsmokers MDA level (1.32 ± 0.90 nmol/mL) (p=0.092). Conclusions Smoking tends to decrease plasma GSH levels and increase plasma MDA levels in medical students. Smoking history could be evidence of oxidative stress and an impaired oxidant defense system. In particular, young smokers should quit promptly before health problems arise, so as to have the optimal benefits of cessation.

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“…Free radicals are molecules or fragments of molecules that contain an unpaired electron in their atomic or molecular orbitals, which include reactive oxygen species (ROS) and non-radical reactive oxygen species [ 30 ]. The most important ROS are the hydroxyl radical ( • OH), superoxide-anion (O 2 − ), hydrogen peroxide, and singlet oxygen, which can badly damage the membrane lipids, proteins, and DNA, leading to loss of function and eventually death of the organism [ 31 , 32 ]. In the current research, the results indicated that the radical scavenging activities of DPPH, ABTS, hydroxyl, and superoxide-anion of pinocembrin–lecithin complex were distinctly higher than those of pinocembrin.…”

Section: Discussionmentioning

confidence: 99%

Pinocembrin–Lecithin Complex: Characterization, Solubilization, and Antioxidant Activities

et al. 2018

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Pinocembrin is a natural flavonoid compound which is capable of antioxidant, antibacterial, anti-inflammatory, and antineoplastic activities. The present study aimed to enhance the solubility and antioxidant activities of pinocembrin by complex formation with lecithin. The physicochemical characteristics of pinocembrin–lecithin complex were analyzed by ultraviolet (UV), fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and solubility assay, and the antioxidant activities of pinocembrin–lecithin complex were evaluated via radical scavenging capacities for 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS), hydroxyl, and superoxide-anion. The results indicated that pinocembrin complex with lecithin could significantly improve the solubility of pinocembrin in water and n-octane, the pinocembrin–lecithin complex displayed no characteristic endothermic peak and the appearance of amorphous state, compared to the pinocembrin, and no new covalent bond was produced in the pinocembrin and lecithin compound. It was demonstrated that the antioxidant activities of pinocembrin were obviously enhanced by the complex with lecithin, and the scavenging capacities for hydroxyl radical, DPPH, superoxide-anion radical, and ABTS radical of pinocembrin–lecithin complex were 82.44 ± 2.21%, 40.07 ± 1.32%, 59.15 ± 0.86%, and 24.73 ± 1.04% at 1.0 mg/mL, respectively. It suggested that the pinocembrin–lecithin complex had a great potential application prospect in the healthcare industry and in clinical practice.

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Estimation of lipid peroxides and antioxidants in smokers and non-smokers with periodontitis

Cited by 7 publications

References 17 publications

Smoking Effects on Blood Antioxidants Level: Lactate Dehydrogenase, Catalase, Superoxide Dismutase and Glutathione Peroxidase in University Students

Smoking Effects on Blood Antioxidants Level: Lactate Dehydrogenase, Catalase, Superoxide Dismutase and Glutathione Peroxidase in University Students

Smoking tends to decrease glutathione and increase malondialdehyde levels in medical students

Pinocembrin–Lecithin Complex: Characterization, Solubilization, and Antioxidant Activities

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