Conflito de interesses:Não Contribuição dos autores: HRPB coleta, tabulação, delineamento do estudo e redação do manuscrito, EMN, ALDB delineamento do estudo, RCR discussão dos achados, EVLS discussão dos achados, MNAS orientação do projeto, delineamento do estudo e elaboração do manuscrito Contato para correspondência: Elicarlos Marques Nunes E-mail: elicarlosnunes@yahoo.com. Abstract Introduction: Burnout Syndrome is a disorder, which is increasingly affecting professionals, and among many working classes, nursing professionals stood out, because they are more exposed to aggravating factors responsible for the development of this syndrome. Objective: Analyze and compare the prevalence of the Burnout Syndrome in nurses working in primary health care, as well as in tertiary health care. Patients and Method: This is a descriptive study with a quantitative approach. The study was carried out in the municipality of Patos, state of Paraíba, Brazil. The sample used was non-probabilistic for convenience, deter-mined by adequacy to the inclusion and exclusion criteria, with 29 primary care nurses and 49 tertiary nurses participating in the study. Data collection was performed in September 2015, using a questionnaire to identify the sample social and demographic profile and the Maslach Burnout Inventory (MBI) to measure the incidence of the aforementioned complaint. Data were stored and analyzed in the Statistical Package for the Social Sciences and descriptive statistics were used. In addition, the reliability or internal consistency of the factors within the Burnout scale was verified through Cronbach's Alpha. Student's t test and Pearson's correlation were used as inferential tests. We considered p ≤ 0.05 as statistically significant. Results: It was verified that 64.1% of the sample presented low emotional exhaustion, 52.6% presented an average professional accomplishment, and 85.9% low depersonalization. No statistically significant differences were observed in the comparison of nursing professionals affected by Burnout in primary and tertiary health care. It was noticed that primary health care professionals are less professionally fulfilled when compared to tertiary health care professionals. Conclusion: The research results showed relevance, especially when the objective is to pay attention to the professional's health through the search of strategies in the health promotion of these professionals.