Estrogenic effects of aldrin and quinalphos in rats

Chatterjee, S.; Ray, Aritra; Bagchi, Preenon; Deb, Chandicharan

doi:10.1007/bf00197494

Cited by 17 publications

(17 citation statements)

References 5 publications

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“…We found that a number of organophosphorustype pesticides possess estrogenic and/or antiandrogenic activities. To date, it has been reported that tolclofos-methyl and quinalphos act as ER agonists Chatterjee et al 1992) and that fenitrothion, parathion, and methyl parathion act as AR antagonists (Sohoni et al 2001;Tamura et al 2001). We also found that tolclofos-methyl and quinalphos have estrogenic activities via ERα and ERβ, and that fenitrothion, parathion, and methyl parathion have antiandrogenic activities via AR.…”

Section: Discussionsupporting

confidence: 56%

Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.

Kojima

Katsura

Takeuchi

et al. 2004

Environ Health Perspect

460

314

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We tested 200 pesticides, including some of their isomers and metabolites, for agonism and antagonism to two human estrogen receptor (hER) subtypes, hERalpha and hERbeta, and a human androgen receptor (hAR) by highly sensitive transactivation assays using Chinese hamster ovary cells. The test compounds were classified into nine groups: organochlorines, diphenyl ethers, organophosphorus pesticides, pyrethroids, carbamates, acid amides, triazines, ureas, and others. These pesticides were tested at concentrations < 10-5 M. Of the 200 pesticides tested, 47 and 33 showed hER- and hERbeta-mediated estrogenic activities, respectively. Among them, 29 pesticides had both hERalpha and hERbeta agonistic activities, and the effects of the organochlorine insecticides beta-benzene hexachloride (BHC) and delta-BHC and the carbamate insecticide methiocarb were predominantly hERbeta rather than hERalpha agonistic. Weak antagonistic effects toward hERalpha and hERbeta were shown in five and two pesticides, respectively. On the other hand, none of tested pesticides showed hAR-mediated androgenic activity, but 66 of 200 pesticides exhibited inhibitory activity against the transcriptional activity induced by 5alpha-dihydrotestosterone. In particular, the antiandrogenic activities of two diphenyl ether herbicides, chlornitrofen and chlomethoxyfen, were higher than those of vinclozolin and p,p -dichlorodiphenyl dichloroethylene, known AR antagonists. The results of our ER and AR assays show that 34 pesticides possessed both estrogenic and antiandrogenic activities, indicating pleiotropic effects on hER and hAR. We also discussed chemical structures related to these activities. Taken together, our findings suggest that a variety of pesticides have estrogenic and/or antiandrogenic potential via ER and/or AR, and that numerous other manmade chemicals may also possess such estrogenic and antiandrogenic activities.

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Section: Discussionsupporting

confidence: 56%

Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.

Kojima

Katsura

Takeuchi

et al. 2004

Environ Health Perspect

460

314

View full text Add to dashboard Cite

show abstract

“…Because the algal quality does not affect the duration of embryonic development of the rotifers (King 1967;Xi and Huang 1999), aldrin at 0.04-1.28 mg/L may directly affect the embryonic development of the rotifers. Interestingly, dieldrin, chlordecone and aldrin all have estrogenic activity (Chatterjee et al 1992;Scippo et al 2004). However, whether their significant effects on the duration of embryonic development of rotifers are attributed to their endocrine disrupting activity or structure similarity needs further researching, because information on the endocrinology of rotifer reproduction is still scarce.…”

Section: Resultsmentioning

confidence: 99%

“…Chronic exposure of animals and human beings to aldrin or dieldrin has resulted in dose-related hepatomegaly and histological changes (Jager 1970;Edwards and Priestly 1994;Huyer 1998). Aldrin demonstrates estrogenic activity by a series of assays such as increase in the weights of uteri in immature and ovariectomized mature rats and binding capacity to recombinant human steroid receptors (Chatterjee et al 1992;Scippo et al 2004). Like other organochlorine insecticides, aldrin can enter into aquatic environment by direct or indirect routes.…”

mentioning

confidence: 99%

Effect of Aldrin on Life History Characteristics of Rotifer Brachionus calyciflorus Pallas

Huang

Zha

et al. 2007

Bull Environ Contam Toxicol

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The organochlorine insecticide aldrin is commonly used in intensive agriculture, and demonstrates estrogenic activity. Rotifers such as Brachionus calyciflorus are favored test animals in aquatic toxicology because of their more sensitivity to most toxicants. In the tested concentration range of 0.04-1.28 mg/L, aldrin shortened significantly the durations of embryonic development. Lower concentrations of aldrin had an intriguing effect on the reproduction of the rotifers and are beneficial to their survival. Different endpoints of both development and reproduction had different sensitivity to aldrin. The reproductive endpoint of the rotifers is more sensitive to aldrin than the developmental endpoint.

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“…The potential estrogenic activity of aldrin remains unclear. It has been reported to yield uterotrophic effects and increased endometrial proliferation at very high doses in some studies but in others showed no detectable uterotrophic activity even at 1,000 mg/kg (23,24). Similarly, dieldrin has been reported to be weakly estrogenic (19) or nonuterotrophic alone (24) or in combination with endosulfan (25).…”

Section: Discussionmentioning

confidence: 99%

Gene induction studies and toxicity of chemical mixtures.

Mumtaz

Tully

El‐Masri

et al. 2002

Environ Health Perspect

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As part of its mixtures program, the Agency for Toxic Substances and Disease Registry (ATSDR) supports in vitro and limited in vivo toxicity testing to further our understanding of the toxicity and health effects of chemical mixtures. There are increasing concerns that environmental chemicals adversely affect the health of humans and wildlife. These concerns have been augmented by the realization that exposure to chemicals often occurs to mixtures of these chemicals that may exhibit complex synergistic or antagonistic interactions. To address such concerns, we have conducted two studies with techniques that are being used increasingly in experimental toxicology. In the first study, six organochlorine pesticides (

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Estrogenic effects of aldrin and quinalphos in rats

Cited by 17 publications

References 5 publications

Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.

Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.

Effect of Aldrin on Life History Characteristics of Rotifer Brachionus calyciflorus Pallas

Gene induction studies and toxicity of chemical mixtures.

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