Ethanol and Oxidative Stress

Abstract

This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chair was Albert Y. Sun. The presentations were (1) Ethanol-inducible cytochrome P-4502E1 in alcoholic liver disease, by Magnus Ingelman-Sundberg and Etienne Neve; (2) Regulation of NF-kappaB by ethanol, by H. Matsumoto, Y. Nishitani, Y. Minowa, and Y. Fukui; (3) Chronic ethanol consumption increases concentration of oxidized proteins in rat liver, by Shannon M. Bailey, Vinood B. Patel, and Carol C. Cunningham; (4) Antiphospholipids antibodies and oxidized modified low-density lipoprotein in chronic alcoholic patients, by Tomas Zima, Lenka Fialova, Ludmila Mikulikova, Ptr Popov, Ivan Malbohan, Marta Janebova, and Karel Nespor; and (5) Amelioration of ethanol-induced damage by polyphenols, by Albert Y. Sun and Grace Y. Sun.

Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney

“…12,13 Thus, chronic and excessive alcohol consumption may accelerate oxidative mechanism directly or indirectly, which eventually produces cell death and tissue damage. 14 Ascorbic acid (vitamin C) is a low molecular mass antioxidant that interacts directly with the oxidizing radicals and protects the cells from ROS. 15 Vitamin C scavenges the ROS by very rapid electron transfer that, thus, inhibits lipid peroxidation.…”

Neurotoxicity and Metabolism of the Catecholamine-Derived 3,4-Dihydroxyphenylacetaldehyde and 3,4-Dihydroxyphenylglycolaldehyde: The Role of Aldehyde Dehydrogenase

“…For example, the impaired metabolism of various endogenous aldehydes is causally associated with many diseases, including Sjögren-Larsson syndrome (Rizzo and Carney, 2005), type II hyperprolinemia (Valle et al, 1976), ␥-hydroxybutyric aciduria (Pearl et al, 2003), pyridoxinedependent seizures (Mills et al, 2006), and hyperammonemia and hypoprolinemia (Baumgartner et al, 2000). In addition, lipid-derived aldehydes, such as 4-HNE, acrolein, and MDA, have been implicated in alcohol-related diseases, including alcoholic liver disease, fibrosis, and atherosclerosis (Poli, 2000;Sun et al, 2001), and neurological diseases, such as PD and AD (Yoritaka et al, 1996;Lovell et al, 2001). Similarly, impaired metabolism of the ethanol metabolite acetaldehyde has been implicated in many alcohol-related diseases, including cirrhosis (Enomoto et al, 1991;Chao et al, 1994) and numerous head and neck cancers (Muto et al, 2000;Yokoyama et al, 2001), and late onset AD (Kamino et al, 2000).…”

Effects of Puffer (Sphoeroides rubripes) Supplementation on Disruption of Antioxidant Defense Systems in Ethanol-Treated Rats

“…3 Values are meansϮSE for 7 animals in each group. 4 NS: not significant. 5 Means with the same superscripts in each row are not significantly different (pϽ0.05).…”