Ethanolic extract of the natural product of Daun sirih (Piper betle) leaves may impede the effectiveness of the plasma jet contact style for acute wounds

Rahayu, Heni Setyowati Esti; Nasruddin,; Nurani, Laela Hayu; Darmawati, Sri; Rohmani, Afiana; Lutfiyati, Heni; Wahyuningtyas, Eka Sakti; Sikumbang, Isabella Meliawati; Muhlisin, Zaenul; Sukeksi, Andri; Nuroini, Fitri; Ishijima, Tatsuo; Sugama, Junko; Nakatani, Toshio

doi:10.1016/j.cpme.2019.100090

Cited by 10 publications

(8 citation statements)

References 45 publications

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“…According to Thi et al (2021), Piper betle leaves have been shown to possess a phenolic component that has the capacity to heal cutaneous tissue wounds. A similar study found ethanolic extract of Piper betle L. was effective for healing acute wounds in rats (Rahayu et al 2019). Several cattle breeders also mentioned that the leaves of this plant are crucially effective for treating diarrhea and detoxification.…”

Section: Discussionmentioning

confidence: 90%

Ethnoveterinary study of medicinal plants used for cattle treatment in Bojonegoro District, East Java, Indonesia

et al. 2021

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Abstract. Pratama AM, Herawati O, Nabila AN, Belinda TA, Wijayanti AD. 2021. Ethnoveterinary study of medicinal plants used for cattle treatment in Bojonegoro District, East Java, Indonesia. Biodiversitas 22: 4236-4245. Bojonegoro is a rural district in Indonesia's East Java Province where farming and cattle rearing are the main economic activities. The Bojonegoro District's cattle producers employ some medicinal plants specifically for the treatment of bovine illnesses. However, no data has been reported thus far. The goal of this research was to find and document ethnoveterinary medicinal herbs for cattle cures in the Bojonegoro District. A total of 41 cattle breeders were interviewed for the study. To collect demographic and ethnoveterinary medicinal plant data, each informant was interviewed using a semi-structured questionnaire in the native language of each informant. The stastitical analysis in this study include informant consensus (Fic), Fidelity Level (FL), and Plant Part Frequency (PPF). Approximately 78.00% of the respondents are between the ages of 30 and 50, with 36.59% having only graduated from senior high school. The Peranakan Ongole (PO) is the most common breed preserved by cattle breeders. In the study area, 41 ethnoveterinary medicinal plants were mentioned by male respondents to cure cattle health problems. Digestive illnesses are the most frequent ailments in cattle treated with medicinal plants. Curcuma longa L. was the most commonly mentioned medicinal plant. A majority of the source ethnoveterinary medicinal plants were cultivated on-site and the leaves of these plants were most often used.

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Section: Discussionmentioning

confidence: 90%

Ethnoveterinary study of medicinal plants used for cattle treatment in Bojonegoro District, East Java, Indonesia

et al. 2021

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“…Based on research from Dartini et al (2017), it was mentioned that using chlorine solution as a disinfection material on radiographic cassettes is effectively 2% better than using alcohol with a content of 70%. In this study, researchers used betel leaf oil with the consideration that it is a natural ingredient, easy to obtain in Indonesia, and the use of local wisdom as a material of value in the community, besides that because it is a natural ingredient, it will not provide side effects in the form of irritation to the skin or damage the surface on the radiographic cassettes (Emrizal et al, 2014;Rahayu et al, 2019;Melgar et al, 2022;Thi et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Betel Leaf Oil as a Natural Disinfection Agent in Radiological Equipment (Study of Microbial Quantity of Radiographic Cassette)

et al. 2023

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Background: Betel leaf oil is a wonderful natural antiseptic. Betel leaf oil is rich in polyphenols, especially chavicol, which can be used to protect against microbe pathogens that cause infection. The cause of the spread of nosocomial infections in radiology can occur using a radiographic cassette. Previous research has found that radiographic cassette contains microorganisms and fungi. Purpose: To determine the effectiveness of using betel leaf oil as a natural disinfection on a radiographic cassette. Method: Quasi-experimental research with pre-test and post-test design designs was carried out by calculating the number of microbes, including Total Plate Count (TPC), Staphylococcus, and fungi. The study on 12 conventional radiographic cassettes was calculated using the swab method before and after cleaning with betel leaf oil. The data were analyzed descriptively to illustrate the rate of decline. Result: The results showed that the percentage rate of decline after the radiographic cassette was cleaned with betel leaf oil was ALT (17.8%), Staphylococcus (57.41%), and fungi (37.21%). Conclusion: Betel leaf oil can be used as alternative natural disinfection on radiographic cassettes, quite effectively suppressing the activity and number of microbes present.

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“…Hasil penelitian yang dilakukan oleh Zar'ah et al (2021) secara in vivo menunjukkan bahwa ekstrak daun sirih berpengaruh terhadap penyembuhan luka pada mencit. Rahayu et al (2019) melaporkan bahwa pemberian ekstrak daun sirih pada mencit yang mengalami luka akut dapat mempercepat fase inflamasi, meningkatkan neoepitelisasi dan pembentukan kolagen baru sehingga mempercepat penyembuhan luka akut (Rahayu et al, 2019). Pemberian ekstrak daun sirih juga dapat meningkatkan penyembuhan luka yang tertunda pada diabetes mellitus dengan mengurangi penanda stres oksidatif dan ekspresi 11b HSD-1 (Ghazali et al, 2016).…”

Section: Pendahuluanunclassified

“…Kemudian mencit diberi perlakuan spray ekstrak daun sirih sebanyak 2 kali semprot sehari. Dilakukan observasi pada proses penyembuhan luka setiap hari mulai hari ke-0 hingga hari ke-14 (Nasruddin et al, 2014;Rahayu et al, 2019).…”

Section: Pembuatan Luka Akut Dan Perlakuan Hewan Ujiunclassified

“…Hal tersebut menunjukkan bahwa spray sirih dapat memengaruhi penyembuhan luka dibandingkan dengan kontrol negatif. Pengamatan luka dilakukan selama 14 hari merujuk pada penelitian yang dilakukan oleh Rahayu et al (2019), yaitu mengamati fase inflamasi, proliferasi, dan remodeling yang terjadi dalam rentang waktu 14 hari (Rahayu et al, 2019). Hasil histologi menunjukkan bahwa kelompok yang diberi perlakuan daun sirih dan kontrol positif menunjukkan penebalan epitel yang signifikan apabila dibandingkan dengan kelompok kontrol negatif (Gambar 2).…”

Section: Hasil Dan Pembahasanunclassified

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The Effect of Betel Leaf Extract Spray on Histopathology of Wound Healing

Nurani

Sikumbang

Yuliani

et al. 2022

JFSP

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Wounds are referred to as 'Silent Epidemic' because they have a substantial impact if not treated properly. Betel leaf is known to contain compounds that may be used as wound healers. The purpose of this study was to test the spray activity of betel leaf extract (Piper betle L) in healing acute wounds in male Balb/C mice. Spray formula made with various concentrations of betel leaf extract by 3% (S1), 5% (S2) and 7% (S3). The acute wound healing activity test was 15 mice divided into 5 groups S1, S2, S3, P (positive control), and C (negative control). Interventions and observations were carried out for 14 days. The results of observational analysis by calculating the ratio of wound area then One Way Anova test and Post Hoc Tukey Cramer test. The results showed that spray of betel leaf extract with a concentration of 7% was not significantly different from P (p>0.05). The conclusion in this study is that sprays of betel leaf extract 3%, 5%, and 7% may be used as an acute wound healer, the best healing activity is shown at a concentration of 7%.

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Ethanolic extract of the natural product of Daun sirih (Piper betle) leaves may impede the effectiveness of the plasma jet contact style for acute wounds

Cited by 10 publications

References 45 publications

Ethnoveterinary study of medicinal plants used for cattle treatment in Bojonegoro District, East Java, Indonesia

Ethnoveterinary study of medicinal plants used for cattle treatment in Bojonegoro District, East Java, Indonesia

Betel Leaf Oil as a Natural Disinfection Agent in Radiological Equipment (Study of Microbial Quantity of Radiographic Cassette)

The Effect of Betel Leaf Extract Spray on Histopathology of Wound Healing

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