2008
DOI: 10.1016/j.joen.2007.11.004
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Eugenol Inhibited the Antimicrobial Functions of Neutrophils

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Cited by 11 publications
(6 citation statements)
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“…It is thought that free eugenol component of freshly mixed ZOE sealer can seep out and cause various cytotoxic effects on human gingival fibroblasts, periodontal ligament cells, and osteoblast-like cells (20)(21)(22)(23). However, Haseih et al (24) reported that leakage of eugenol into periapical tissues is very low, and it dramatically decreases over time.…”
Section: Discussionmentioning
confidence: 99%
“…It is thought that free eugenol component of freshly mixed ZOE sealer can seep out and cause various cytotoxic effects on human gingival fibroblasts, periodontal ligament cells, and osteoblast-like cells (20)(21)(22)(23). However, Haseih et al (24) reported that leakage of eugenol into periapical tissues is very low, and it dramatically decreases over time.…”
Section: Discussionmentioning
confidence: 99%
“…After the bacterial infection has spread beyond the apical foramen, activated neutrophils assemble in the periapical tissue and phagocytize the bacteria. Neutrophil has the defense mechanism involved in the killing of invading bacteria by the liberation of reactive oxygen species (32) and lysosomal enzymes (20). In these serine proteinases, elastase, cathepsin G, and proteinase 3 have elastinolytic activity.…”
Section: Discussionmentioning
confidence: 99%
“…22 It has been also reported that eugenol caused a significant reduction in MPO release by human neutrophils, but at high concentrations, between 0.625 mM (102.6 μg/mL) and 2.5 mM (410.5 μg/mL). 23 Finally, it should be noted that papers dealing with in vitro testing of essential oils or their constituents in the isolated MPO enzyme were not found in literature.…”
Section: ■ Introductionmentioning
confidence: 99%