Evaluation of a modified acetaminophen absorption test to estimate the abomasal emptying rate in Holstein-Friesian heifers

Ehsani-Kheradgerdi, Abdullah; Sharifi, Kamran; Mohri, Mehrdad; Grünberg, Walter

doi:10.2460/ajvr.72.12.1600

Cited by 7 publications

(8 citation statements)

References 45 publications

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“…tulathromycin in healthy goats was demonstrated by a shorter time to actual T max and model T max , as well as a shorter abomasal emptying half-time (T50), than control. The elimination half time of acetaminophen in this study appeared to be shorter than that reported for cattle (Grochowina and Janus, 2007;Ehsani-Kheradgerdi et al, 2011) and lambs (Sharifi et al, 2009). This result in consistent with a more active metabolism in goats than in cattle or sheep, with goats having a significantly higher activity of UDP-glucuronyltransferase (Short et al, 1988) and higher liver concentrations of cytochrome p-450, NADPH cytochrome c reductase, aldrin epoxidase, aminopyrine Ndemethylase, ethoxycoumarin O-deethylase, microsomal and cytosolic stilbene oxide (epoxide) hydrolase and glutathione s-transferase than sheep and cattle (Wisniewski et al, 1987).…”

Section: Discussioncontrasting

confidence: 78%

“…Six weeks later goats received an IM injection of tulathromycin (2.5 mg/kg BW) into the semimembranosus muscle; the duration between tulathromycin injections was to ensure adequate clearance of tulathromycin, based on an estimated mean half-life after IV injection of 4.1 days in these goats (Amer et al, 2012) and 2.5-4.6 days after SC injection in juvenile and market aged goats (Clothier et al, 2011;Young et al, 2011;Romanet et al, 2012). A wash out period of a week was considered adequate for complete clearance of acetaminophen, based on pharmacokinetic studies in cattle (Grochowina and Janus, 2007;Ehsani-Kheradgerdi et al, 2011) and sheep (Sharifi et al, 2009).…”

Section: Experimental Designmentioning

confidence: 99%

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Effect of tulathromycin on abomasal emptying rate in healthy lactating goats

Badawy

Amer

Constable

et al. 2014

Small Ruminant Research

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Section: Discussioncontrasting

confidence: 78%

Section: Experimental Designmentioning

confidence: 99%

Effect of tulathromycin on abomasal emptying rate in healthy lactating goats

Badawy

Amer

Constable

et al. 2014

Small Ruminant Research

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“…Ehsani-Kheradgerdi et al . [ 6 ] examined the pharmacokinetics of AAP after its abomasal administration to Holstein-Friesian heifers. They demonstrated that T max was 80 min.…”

Section: Discussionmentioning

confidence: 99%

Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle

Sawaguchi

Sasaki

Miyanaga

et al. 2016

The Journal of Veterinary Medical Science

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The oral pharmacokinetics of diclofenac (DF) were evaluated in cattle by analyzing plasma concentration-time data after its intravenous and oral administration in order to propose the oral administration of DF as effective route to avoid long withdraw period. DF was intravenously and orally administered at 1 mg/kg to cattle using a crossover design with a 4-week washout period. Plasma concentrations of DF were determined by a HPLC analysis. The mean absorption time (MAT) and absorption half-life (t1/2ka) were 1.61 ± 0.61 and 1.51 ± 0.38 hr, respectively, and bioavailability was nearly 100%. The oral pharmacokinetics of acetaminophen (AAP) were also evaluated in cattle. Plasma concentrations of AAP were determined by a HPLC analysis. MAT and t1/2ka were 2.85 ± 0.93 and 1.53 ± 0.28 hr, respectively, and bioavailability was approximately 70%. In conclusion, the results of the present study indicate that DF and AAP are rapidly absorbed from the forestomach of cattle. Therefore, the appropriate efficacies of these drugs may be achieved via their oral administration, even in cattle.

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“…These results confirmed an impaired acid‐base balance at least in D but to a lesser extent in DORS. The APAT model was used to determine the AER indices that have already been described in previous studies with healthy ruminants and healthy calves (Ehsani‐Kheradgerdi, Sharifi, & Mohri, ; Marshall et al, ; Nouri & Constable, ). Calves are functional monogastric individuals with a biphasic gastric emptying which is best described by the equation of Siegel (Marshall et al, ).…”

Section: Discussionmentioning

confidence: 99%

Abomasal emptying rate of diarrhoeic and healthy suckling calves fed with oral rehydration solutions

Hildebrandt

Scheuch

Schneider

et al. 2020

Animal Physiology Nutrition

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The aim of the study was to determine the abomasal emptying rate (AER) of calves suffering from naturally occurring diarrhoea compared with that of healthy calves. Furthermore, the effects of an oral rehydration solution (ORS) mixed into milk replacer on the AER were determined. Acetaminophen absorption test (APAT) was performed to estimate the AER. Sixty Holstein–Frisian calves (age < 14 days) were included in the study and divided into groups as follows: healthy calves (H; n = 16), healthy calves fed with ORS (HORS; n = 14), diarrhoeic calves (D; n = 15) and diarrhoeic calves fed with ORS (DORS; n = 15). For the APAT, the calves were fed 2 L of milk replacer containing 50 mg acetaminophen (AP)/kg body weight. Venous blood samples were collected before and after milk replacer and AP intake in 30–60 min intervals for 12 hr. During the APAT, no significant differences in median maximum acetaminophen concentration (Cmax) were observed among all groups. Time to reach maximum acetaminophen concentration (Tmax) in DORS (median 390 min, 25/75 quartiles: 300/480 min) was significantly higher compared with that in H (median: 270 min 25/75 quartiles: 210/315 min) and HORS (median: 300 min (25/75 quartiles: 240/360 min). Non‐linear regression revealed that the calculated abomasal half‐life (AP t1/2) tended to be delayed in DORS (median: 652 min, 25/75 quartiles: 445/795 min, p = .10). The area under the AP curve values (AUC) from 0 to 120 min and 0 to 240 min of the observation period were significantly higher in H than D and DORS. In conclusion, significant differences in the AER indices reflected delayed abomasal emptying in diarrhoeic calves. Furthermore, the hypertonic ORS tended to have an additive delaying impact on the AER, which needs attention for the feeding management of diarrhoeic calves.

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Evaluation of a modified acetaminophen absorption test to estimate the abomasal emptying rate in Holstein-Friesian heifers

Abstract: The modified acetaminophen absorption test was a practical, minimally invasive, and reliable method to assess abomasal emptying in cattle. Metoclopramide administered at a dose of 0.1 mg/kg did not increase the abomasal emptying rate.

Cited by 7 publications

References 45 publications

Effect of tulathromycin on abomasal emptying rate in healthy lactating goats

Effect of tulathromycin on abomasal emptying rate in healthy lactating goats

Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle

Abomasal emptying rate of diarrhoeic and healthy suckling calves fed with oral rehydration solutions

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