Evaluation of Anti-anxiety Activity of Justicia gendarussa Burm

Natesan, Subramanian; Jothimanivannan, C.; Kumar, Ravi; Kameshwaran, S.

doi:10.5567/pharmacologia.2013.404.407

Cited by 14 publications

(2 citation statements)

References 8 publications

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“…Leaves contain, alkaloids, lavonoids, saponin, steroids, O-distributed aromatic amine i.e., 2-(2'-amino-benzylamino) benzyl alcohol and their respective O-methyl ethers, stigmasterol, lupeol, 16-hydroxylupeol, 28β-sitosterol (Ashish et al, 2020). The plant shows the various therapeutic activity like, anti-arthritic (Paval et al, 2009b,a), anti-in lammatory (Kavitha et al, 2011), antibacterial (Kumar et al, 2018), dyspepsia (Kumar et al, 2012), cytotoxic (Ayob et al, 2014), antiangiogenic (Mangai, 2018), anti-fungal (Ayob et al, 2013), Cough (Patel and Zaveri, 2012), hepatoprotective (Krishna et al, 2010;Phukan et al, 2014), anti-anxiety activity (Jothimaniv et al, 2013), antidepressant effect (Mythili and Jothimanivannan, 2017), sedative and hypnotic activity (Jothimaniv et al, 2013), anti-diabetic (Islam et al, 2015).…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Pharmacological and Biochemical evaluation of anti-arthritic activity of Justicia gendarussa extract in FCA induced arthritis in Wistar rats

Ashish¹,

Anjali

Dixit

et al. 2021

ijrps

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The present study is carried out to evaluate anti-inflammatory and anti-arthritic potential of Justicia gendarussa. Leaves and stem extracted with ethanol and chloroform. These extract is tested against in-vitro (HRBC membrane stabilization method and Inhibition of protein denaturation method) and in-vivo (Carrageenan induced paw edema model) anti-inflammatory models. To assess the anti-arthritic activity, FCA induced arthritis model is used. Assessment of arthritis is done by paw volume, joint diameter, body weight, biochemical parameters, hematological parameters (Hb, RBC, WBC, ESR). The effect of in-vitro anti-inflammatory model depends on concentration. Both test extract and standard Diclofenac sodium has been shown concentration dependent effect. The maximum anti-inflammatory effect of the test extract achieved at 2000μg/ml. The test (JGLE, JGLC, JGSE) has been shown inhibition of paw edema induced by carrageenan at 50mg/kg body weight. The extract JGLE, JGLC, JGSE at 50mg/kg body weight and 100mg/kg body weight orally showed the significant (P< 0.05) and dose dependent inhibitory effect against FCA induced arthritis model. Diclofenac sodium 20mg/kg body weight orally is used as a standard. JGLE exhibit more significant and most promising anti-arthritic and anti-inflammatory effect than other extracts these effects support the traditional role of J. gendarussa in arthritis and other inflammatory condition.

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Section: Rheumatoid Arthritismentioning

confidence: 99%

Pharmacological and Biochemical evaluation of anti-arthritic activity of Justicia gendarussa extract in FCA induced arthritis in Wistar rats

Ashish¹,

Anjali

Dixit

et al. 2021

ijrps

View full text Add to dashboard Cite

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“…Aerial part extract of (95% v/v ethanol) Justicia gendarussa shows the anti-anxiety activity on the swiss albino mice of either sex by elevated plus maze test and light dark test at the concentration of 250 and 500 mg kg −1 b.wt. orally (Jothimaniv et al, 2013).…”

Section: Anti-anxiety Activitymentioning

confidence: 99%

Pharmacognostical and pharmacological activity of Justicia gendarussa burm.f.: a comprehensive review

Ashish¹,

Anjali²,

K³

et al. 2020

ijrps

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Justicia gendarussa Burm .f. (family Acanthaceae) which is also known as willow-leaves and commonly known as Nili-Nirgundi, it is very commonly found nearby to China and its availability is very common in larger parts of India and Andaman islands. Traditionally it is used to treat various sorts of disorders such as wound healing, anti-inflammatory, anti-oxidant, antiproliferative, anti-arthritic etc. Justicia gendarussa is one of the crucial herbs which has been used in the Ayurveda. Majorly leaves parts of the plant shows the pharmacological activity but the root of the plant Justicia gendarussa is also have the important medicinal values. A large variety of pharmacologically active constituents i.e., alkaloids, flavonoids, saponin, carbohydrates, steroids, triterpenoids, carotenoids, aminoacids, tannins, phenolics, coumarines and anthaquinones are also present in this plant and they makes the plant pharmacologically important. The activity of the plant is also dependent on the solvent which is used for the extraction the various vital chemical constituents. The different- different parts of the plants having the different medicinal values also differ in the chemical values. This review is not only focused on the essential phytochemical constituents which is available in the plant but it also explains their necessary medicinal value to shows the essential biological action and phytopharmacological actions of various parts of the plant.

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Evidence for the involvement of a GABAergic mechanism in the effectiveness of natural and synthetically modified incensole derivatives in neuropharmacological disorders: A computational and pharmacological approach

et al. 2019

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Evaluation of Anti-anxiety Activity of Justicia gendarussa Burm

Cited by 14 publications

References 8 publications

Pharmacological and Biochemical evaluation of anti-arthritic activity of Justicia gendarussa extract in FCA induced arthritis in Wistar rats

Pharmacological and Biochemical evaluation of anti-arthritic activity of Justicia gendarussa extract in FCA induced arthritis in Wistar rats

Pharmacognostical and pharmacological activity of Justicia gendarussa burm.f.: a comprehensive review

Evidence for the involvement of a GABAergic mechanism in the effectiveness of natural and synthetically modified incensole derivatives in neuropharmacological disorders: A computational and pharmacological approach

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