Evaluation of anti-urolithiatic potential of ethyl acetate extract of Pedalium murex L. on struvite crystal (kidney stone)

Abstract

Pedalium murex (L.) is a traditional herb, commonly used for the treatment of kidney stone related problems. Struvite stone can swiftly grow and become ‘staghorn calculi’ in kidney and its associated areas, which is the most aching urological disorder. The present study investigated the anti-urolithiasis activities of ethyl acetate extract of P. murex L. (EAEP) against struvite crystal. The antibacterial activity of EAEP examined against several urease producing bacteria. It showed the minimum bactericidal concentration (MBC) against Escherichia coli and Staphylococcus aureus (>125). On the other hand, total mass, volume, number, growth rate and dissolution rate of synthesised struvite crystals were observed at different concentrations 0.5%, 0.75%, 1% of EAEP and without EAEP. In which, EAEP addition showed appreciably reduced struvite crystal. Alternatively, MgO (300 mg of EAEP/kg/body weight) induced urolithiasis of Wistar albino rat at the rate of 1 ml for 28 days. Various biochemical parameters in serum, urine and histological analysis of kidney were taken for evaluation. Significant results (p < 0.05) were observed in 1% EAEP (300 mg) treated group than cystone treated group. From the histological study, reduced renal damage and glomerular development were observed. Our experiment, P. murex L. enhances the reducing activity on struvite crystal and prevents the crystal formation both in-vitro and in-vivo. It can be suggesting that P. murex L. and its phyto-components could be used as remedy for the management of kidney stone by dissolving the struvite stone in kidney.

Efficacy of cystone versus tamsulosin in treatment of stent-related lower urinary tract symptoms

“…In our study the pain, quality of life and total IPSS were improved more in the intervention versus the placebo group. [12][13][14][15][16] Our study is the first research in the literature, which determines the efficacy of cystone in double-J-induced lower urinary tract symptoms. Moreover, the results of this study demonstrated that despite the painful status of double-J stent insertion, the voiding and storage symptoms were improved by cystone or tamsulosin or their combination, leading to better improvement in the total IPSS and VAS.…”

Investigation of the potential anti-urolithiatic activity of Alhagi maurorum (Boiss.) grown wild in Al-Ahsa (Eastern Province), Saudi Arabia

“…Urolithiasis is defined as the formation of stones within the urinary tract (Kaleeswaran et al, 2018). It is a wellknown disorder that results from integrated biochemical, epidemiological and genetic risk factors (Makasana et al, 2014).…”

“…Several factors have increased the prevalence of urolithiasis: Low-intake of vegetables, fruits and fluids, and high consumption of animal proteins, salt and sweetened beverages contribute significantly in prevalence of the urolithiasis (Yachi et al, 2018). Urinary stone formation happens in roughly 12% of the populace with a repeat rate of 70-80% in man and 47-60% in females (Kaleeswaran et al, 2018). It can likewise forever harm the kidneys, if not treated appropriately (Chandrajith et al, 2019).…”

Antinephrolithiatic Effect of Plantain Juice from Musa paradisiaca Stem on Ethylene Glycol-Induced Renal Calculus in Experimental Wistar Rats

“…It may be the oldest crop still grown today. As early as 200-300 BC, it even reached Asian countries 7 . A herbaceous plant called Musa paradisiaca (Musaceae) has a maximum length of 9 m. It has a sturdy, pseudo-treelike stem and a crown of enormous, long, oval, deep-green leaves that can reach lengths of up to 365 cm and widths of 61 cm and large, successively opening ovate bracts, 15-20 cm long, concave, dark red and somewhat fleshy.…”