2016
DOI: 10.22159/ijcpr.2017v9i1.16605
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Evaluation of Antiulcer Activity of Mucoadhesive Microgranules Containing Ranitidine Hydrochloride in Experimental Rats

Abstract: Objective: Ranitidine hydrochloride is a competitive inhibitor of histamine H2-receptors, the drug of choice in the treatment of ulcer. The drug has a short biological half-life of approximately 2–3 h, thus a sustained release dosage form of ranitidine HCl is desirable. The aim of this study was to formulate and in vitro evaluate micro granules of ranitidine HCl using 8% aloe vera powder due to cytoprotective effects.Methods: Micro granules were prepared by wet granulation method using aloe vera powder as bio-… Show more

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Cited by 4 publications
(2 citation statements)
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“…Reactive oxygen species is one of the endogenous aggressive factors in ulcer and can be excluded by augmenting articulation of antioxidant enzymes such as SOD, CAT and GSH or by eliminating the free radicals like LPO [43,44]. Generation of free radicals including peroxynitrite and hydroxyl radicals are inhibited by an elevated level of superoxide dismutase (SOD) as a result of dismutation of superoxide radicals.…”
Section: Discussionmentioning
confidence: 99%
“…Reactive oxygen species is one of the endogenous aggressive factors in ulcer and can be excluded by augmenting articulation of antioxidant enzymes such as SOD, CAT and GSH or by eliminating the free radicals like LPO [43,44]. Generation of free radicals including peroxynitrite and hydroxyl radicals are inhibited by an elevated level of superoxide dismutase (SOD) as a result of dismutation of superoxide radicals.…”
Section: Discussionmentioning
confidence: 99%
“…The drug should be targeted to a specific site in GIT (absorption window) such as the stomach, intestine, colon [4][5][6] in order to get absorbed. Proton pump inhibitors (PPI) are acid sensitive which need to be administered to deliver in the intestine by enteric coating [7][8].…”
Section: Introductionmentioning
confidence: 99%