Evaluation of Different Sources of Deoxynivalenol (Vomitoxin) Fed to Swine

Foster, Brian; Trenholm, H. L.; Friend, D. W.; Hartin, K. E.; Thompson, B. K.

doi:10.4141/cjas86-128

Cited by 62 publications

(41 citation statements)

References 1 publication

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“…This agrees with the findings of Forsyth et al (1977) and Foster et al (1986) (Friend et al 1986c (Friend et al 1986b). Previous reports (Trenholm et al 1984;Friend et al 1986b,c;Rotter etal.…”

Section: Animals and Housingsupporting

confidence: 83%

“…, 1986b(Friend et aL. , 1986cPollmann et al 1985;Chavez and Rheaume 1986;Foster et al 1986;Marpegan et al 1988). The subsequent improvements in intake and gain are also typical.…”

Section: Animals and Housingmentioning

confidence: 99%

“…However, the extent ofthe refusal of Fusaium contaminated feed in pigs may not always be related to the concentration of DON (Foster et al 1986). It has been suggested that other factors present within these diets may also contribute to the overall toxicological effects (Trenholm et al 1984;Foster et al 1986); or rhar pigs may vary in their tolerance to DON (Bryden et al 1987), possibly because ofdifferences in nutritional or health status or housing conditions (Friend et al 1986b). …”

mentioning

confidence: 99%

See 2 more Smart Citations

Effects of feeding diets containing Fusarium (naturally) contaminated wheat or pure deoxynivalenol (DON) in growing pigs

Trenholm¹,

Thompson²,

Foster³

et al. 1994

Can. J. Anim. Sci.

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Section: Animals and Housingsupporting

confidence: 83%

“…, 1986b(Friend et aL. , 1986cPollmann et al 1985;Chavez and Rheaume 1986;Foster et al 1986;Marpegan et al 1988). The subsequent improvements in intake and gain are also typical.…”

Section: Animals and Housingmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of feeding diets containing Fusarium (naturally) contaminated wheat or pure deoxynivalenol (DON) in growing pigs

Trenholm¹,

Thompson²,

Foster³

et al. 1994

Can. J. Anim. Sci.

Self Cite

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“…0.03c 0.04c a-cMeans within row not sharing a common letter differ (P < 0.05). by Chavez and Rheaume (1986) and Foster et al (1986). In the present study, the analyzed DON levels in the original contaminated corn sample ranged from 12 to l8 mg kg-'.…”

mentioning

confidence: 82%

Efficacy of hydrated sodium calcium aluminosilicate, screening and dilution in reducing the effects of mold contaminated corn in pigs

Patterson¹,

Young²

1993

Can. J. Anim. Sci.

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“…Also, there is evidence of a synergistic effect of gram-negative bacterial endotoxin and β-(1→3)-D-glucan on the influx of inflammatory cells into the alveolar space in the lungs of guinea pigs (Fogelmark et al 1994(Fogelmark et al , 2001). Furthermore, additive or synergistic effects of fungal metabolites have been suggested to be involved in the toxicity of contaminated feed materials (Foster et al 1986) and in the effects of co-occurring fungal metabolites on insects (Dowd et al 1989).…”

mentioning

confidence: 99%

Synergistic interaction in simultaneous exposure to Streptomyces californicus and Stachybotrys chartarum.

Huttunen¹,

Pelkonen²,

Nielsen³

et al. 2004

Environ Health Perspect

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The microbial exposure associated with health complaints in moldy houses consists of a heterogeneous group of components, including both living and dead bacteria, fungi, and their metabolites and active compounds. However, little is known about the interactions between different microbes and their metabolites, although the cytotoxicity and inflammatory potential of certain individual microbes have been reported. In this study, we investigated the inflammatory responses of mouse RAW264.7 macrophages after exposure to six indoor air microbes (Aspergillus versicolor, Penicillium spinulosum, Stachybotrys chartarum, Bacillus cereus, Mycobacterium terrae, and Pseudomonas fluorescens) alone and together with the actinomycete Streptomyces californicus. The production of nitric oxide, levels of the proinflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6), and cytotoxicity were measured. The coexposure to Sta. chartarum and Str. californicus caused a synergistic increase in the production of IL-6 but not other cytokines. In further experiments, the metabolites from Sta. chartarum or from closely related fungi (atranones B and E, satratoxin G, trichodermin, 7-α-hydroxytrichodermol, staplabin, and SMTP-7) and the known fungal toxins sterigmatocystin, citrinin, and ochratoxin A were each tested with Str. californicus. The testing revealed a synergistic response in TNF-α and IL-6 production after coexposure to Str. californicus with both trichodermin and 7-α-hydroxytrichodermol. Finally, the synergistic inflammatory response caused by Str. californicus and trichodermin together was studied by analyzing for the presence of nuclear factor-κB (NF-κB) in nuclear extracts of the exposed cells. The exposure to Str. californicus induced the binding of NF-κB proteins to the NF-κB consensus sequence as well as to the natural NF-κB site of the IL-6 promoter. Adding trichodermin to the exposure did not increase the DNA binding.

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Evaluation of Different Sources of Deoxynivalenol (Vomitoxin) Fed to Swine

Abstract: Fifty-four barrows (27.5 '+ 0.5 kg) were given ad libitum for 7 wk one of 18

Cited by 62 publications

References 1 publication

Effects of feeding diets containing Fusarium (naturally) contaminated wheat or pure deoxynivalenol (DON) in growing pigs

Effects of feeding diets containing Fusarium (naturally) contaminated wheat or pure deoxynivalenol (DON) in growing pigs

Efficacy of hydrated sodium calcium aluminosilicate, screening and dilution in reducing the effects of mold contaminated corn in pigs

Synergistic interaction in simultaneous exposure to Streptomyces californicus and Stachybotrys chartarum.

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