Evaluation of immunomodulation by Lactobacillus casei Shirota: Immune function, autoimmunity and gene expression

Baken, Kirsten; Ezendam, Janine; Gremmer, Eric R.; Klerk, Arja de; Pennings, Jeroen L. A.; Matthee, Bianca; Peijnenburg, Ad; Loveren, Henk Van

doi:10.1016/j.ijfoodmicro.2006.06.009

Cited by 82 publications

(82 citation statements)

References 74 publications

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“…There are several studies showing the exacerbation of experimental autoimmune encephalomyelitis (EAE), a Th1-mediated model of multiple sclerosis, with certain Lactobacillus strains, including the well-established probiotic L. casei Shirota. [191][192][193] However, other probiotic strains are capable of ameliorating EAE, 194 and other experimental autoimmune diseases that are known to be Th1 mediated, such as various models of rheumatoid arthritis [195][196][197] or type 1 diabetes. 198 Together, these fi ndings highlight the need for care in choosing appropriate probiotic strains for particular applications.…”

Section: Final Comments and Thoughtsmentioning

confidence: 99%

Probiotics and immunity

et al. 2009

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Probiotics are defi ned as live microorganisms that, when administered in adequate amounts, confer a health benefi t on the host, including the gastrointestinal tract. While this benefi cial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefi ts by modulating immune functions. In animal models, probiotic supplementation is able to provide protection from spontaneous and chemically induced colitis by downregulating infl ammatory cytokines or inducing regulatory mechanisms in a strain-specifi c manner. In animal models of allergen sensitization and murine models of asthma and allergic rhinitis, orally administered probiotics can straindependently decrease allergen-specifi c IgE production, in part by modulating systemic cytokine production. Certain probiotics have been shown to decrease airway hyperresponsiveness and infl ammation by inducing regulatory mechanisms. Promising results have been obtained with probiotics in the treatment of human infl ammatory diseases of the intestine and in the prevention and treatment of atopic eczema in neonates and infants. However, the fi ndings are too variable to allow fi rm conclusions as to the effectiveness of specifi c probiotics in these conditions.

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Section: Final Comments and Thoughtsmentioning

confidence: 99%

Probiotics and immunity

et al. 2009

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“…However, literature regarding effects of probiotics in the treatment of EAE is controversial. Some authors have observed either exacerbating effects in rat EAE models, with increased Th1 immune responses, or no treatment effect after using probiotics (33)(34)(35). The plausible reasons for such controversies will be discussed later.…”

Section: Probiotic Effects On Extraintestinal Diseasesmentioning

confidence: 99%

“…Additionally, there are several conflicting reports on the protective role of probiotics in the inflammatory disease models discussed (30,35). Such differences could be because of use of different strains of probiotics, different doses and/or different routes of administration.…”

Section: Caveatsmentioning

confidence: 99%

Influence of Dietary Components on Regulatory T Cells

Issazadeh‐Navikas

Teimer

Bockermann

2011

Mol Med

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Common dietary components including vitamins A and D, omega-3 and probiotics are now widely accepted to be essential to protect against many diseases with an inflammatory nature. On the other hand, high-fat diets are documented to exert multiple deleterious effects, including fatty liver diseases. Here we discuss the effect of dietary components on regulatory T cell (Treg) homeostasis, a central element of the immune system to prevent chronic tissue inflammation. Accordingly, evidence on the impact of dietary components on diseases in which Tregs play an influential role will be discussed. We will review chronic tissue-specific autoimmune and inflammatory conditions such as inflammatory bowel disease, type 1 diabetes mellitus, multiple sclerosis, rheumatoid arthritis and allergies among chronic diseases where dietary factors could have a direct influence via modulation of Tregs homeostasis and functions.

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“…The ability of several LAB strains to modulate host innate as well as acquired immune responses, has been demonstrated in many in vitro experiments and animal models (Baken et al, 2006). Certain lactic acid bacteria, orally administered, induce the activation of peritoneal macrophages, which may be important effecter cells in specific and nonspecific host defense (Perdigon et al, 1986).…”

Section: Introductionmentioning

confidence: 99%