Evaluation of immunostimulatory and growth promoting effect of seed fractions of Achyranthes aspera in common carp Cyprinus carpio and identification of active constituents

Chakrabarti, Rina; Srivastava, P. K.; Kundu, Kanika; Khare, Rashmi Sahay; Banerjee, S.

doi:10.1016/j.fsi.2012.02.006

Cited by 32 publications

(20 citation statements)

References 13 publications

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“…Administration of plant extracts through diet into C. carpio is found to elevate myeloperoxidase activity in a similar study conducted elsewhere (Chakrabarti et al 2012). In the present study, myeloperoxidase activity was significantly enhanced by the lowest dose (0.1%) and the highest dose (1%) on all the weeks tested.…”

Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 62%

Polysaccharides from marine macroalga, Padina gymnospora improve the nonspecific and specific immune responses of Cyprinus carpio and protect it from different pathogens

Rajendran¹,

Subramani

Michael

2016

Fish & Shellfish Immunology

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Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 62%

Polysaccharides from marine macroalga, Padina gymnospora improve the nonspecific and specific immune responses of Cyprinus carpio and protect it from different pathogens

Rajendran¹,

Subramani

Michael

2016

Fish & Shellfish Immunology

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“…The amount of leucine, isoleucine, phenylalanine, and valine were similar to the Bengal gram, while tryptophane, methionine, and cystine contents were higher than the most pulses [15]. Chakrabarti et al [6] reported that the presence of ecdysterone in the raw seeds of Achyranthes aspera enhanced the growth rate of Cyprinus carpio common carp. Similarly, in the present study, ecdysterone served as the growth-stimulating component for rohu larvae.…”

Section: Discussionmentioning

confidence: 75%

“…The presence of long-chain polyunsaturated fatty acids such as linolenic and oleic acids have been reported in the seeds of Achyranthes aspera. The immunostimulating effect of seeds may be due to the presence of essential fatty acids [6].…”

Section: Discussionmentioning

confidence: 99%

Impact of UV-B Radiation on the Physiology of Freshwater Carp Labeo rohita Larvae and Evaluation of UV-B Protective Properties of Seeds of Achyranthes aspera and Vitamin C

2013

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Effect of harmful UV-B radiation and their remedial measures have been studied in Labeo rohita (rohu) larvae. Larvae were fed with four different diets: D1 and D2 contained 0.1 and 0.5 % Achyranthes aspera seeds, respectively; D3 contained 800 mg vitamin C/kg diet, and D4 contained control diet. After 50 days, all groups were exposed to UV-B radiation (80 lW/cm 2 ). One batch of control diet-fed fish was exposed to UV-B (D4Ex), and the other group remained unexposed (D4UEx). Survival rate of rohu was significantly (P \ 0.05) higher in D2 when compared to others. Among the exposed groups, highest average weight was recorded in D2 (103 ± 4 mg). Total tissue protein concentration was higher in exposed groups compared to the unexposed one. Glutamic oxaloacetic transaminase (GOT) and glutamate pyruvate transminase (GPT) levels were minimum in unexposed control diet-fed fish. Vitamin C provided protection against lipid peroxidation which was evident from the lowest level of thiobarbituric acid reactive substance in exposed fish (D3). Significantly (P \ 0.05) higher nitric oxide synthase level in fish fed with Achyranthes aspera seeds (0.5 %) supplemented diet showed the immunomodulatory property of the seeds. A combination of vitamin C and seed may be more UV-B protective for carp larvae.

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“…The non-alkaloid fraction of the A. aspera leaf possesses a pronounced anti-carcinogenic effect [5]. Moreover, the ecdysterone found in the seeds of A. aspera have shown both immunostimulatory and growth promoting properties in the larvae of the common carp Cyprinus carpio [6]. Extracts of A. aspera also possess in vivo wound healing activity [7].…”

Section: Introductionmentioning

confidence: 99%

Identification of candidate synovial membrane biomarkers after Achyranthes aspera treatment for rheumatoid arthritis

Zheng

et al. 2016

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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Rheumatoid arthritis (RA) is a systemic autoimmune disease whose main symptom is a heightened inflammatory response in synovial tissues. To verify the anti-arthritic activities of Achyranthes aspera and its possible therapy-related factors on the pathogenesis of RA, the saponins in A. aspera root were isolated and identified to treat the collagen-induced arthritis (CIA) rats. Phytochemical analysis isolated and identified methyl caffeate, 25-S-inokosterone, 25-S-inokosterone β-D-glucopyranosyl 3-(O-β-D-glucopyranosyloxy)-oleanolate, and β-D-glucopyranosyl 3-(O-β-D-galactopyranosyl (1→2)(O-β-D-glucopyranosyloxy)-oleanolate as main compounds in the root of A. aspera. Proteomics was performed to determine the differentially expressed proteins in either inflamed or drug-treated synovium of CIA rats. Treatment resulted in dramatically decreased paw swelling, proliferation of inflammatory cells, and bone degradation. Fibrinogen, procollagen, protein disulfide-isomerase A3, and apolipoprotein A-I were all increased in inflamed synovial tissues and were found to decrease when administered drug therapy. Furthermore, Alpha-1-antiproteinase and manganese superoxide dismutase were both increased in drug-treated synovial tissues. The inhibition of RA progression shows that A. aspera is a promising candidate for future treatment of human arthritis. Importantly, the total saponins found within A. aspera are the active component. Finally, autoantigens such as fibrinogen and collagen could act as inducers of RA due to their aggravation of inflammation. Given this, it is possible that the vimentin and PDIA3 could be the candidate biomarkers specific to Achyranthes saponin therapy for rheumatoid arthritis in synovial membrane.

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Evaluation of immunostimulatory and growth promoting effect of seed fractions of Achyranthes aspera in common carp Cyprinus carpio and identification of active constituents

Cited by 32 publications

References 13 publications

Polysaccharides from marine macroalga, Padina gymnospora improve the nonspecific and specific immune responses of Cyprinus carpio and protect it from different pathogens

Polysaccharides from marine macroalga, Padina gymnospora improve the nonspecific and specific immune responses of Cyprinus carpio and protect it from different pathogens

Impact of UV-B Radiation on the Physiology of Freshwater Carp Labeo rohita Larvae and Evaluation of UV-B Protective Properties of Seeds of Achyranthes aspera and Vitamin C

Identification of candidate synovial membrane biomarkers after Achyranthes aspera treatment for rheumatoid arthritis

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