Evaluation of insulin resistance in idiopathic hirsutism compared with polycystic ovary syndrome patients and healthy individuals

Bonakdaran, Shokoufeh; Kiafar, Bita; Ahmadabadi, Fatemeh Barazandeh

doi:10.1111/ajd.12276

Cited by 10 publications

(14 citation statements)

References 15 publications

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“…4 It is generally accepted that insulin resistance and secondary hyperinsulinemia have a pivotal role in the pathophysiology of PCOS. 5,6 The endocrine and metabolic abnormalities in patients with PCOS also affect the metabolism and function of the endometrium, which may lead to impaired endometrium receptivity, resulting in embryo implantation disorders. 7 Our previous study 8 showed that the insulin levels in endometrial epithelial cells of patients with PCOS were significantly elevated, while glucose transporter-4, an insulin-dependent intracellular glucose transporter protein, exhibited significantly reduced expression, suggesting insulin resistance in the endometrium.…”

Section: Introductionmentioning

confidence: 99%

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Metformin Regulates Key MicroRNAs to Improve Endometrial Receptivity Through Increasing Implantation Marker Gene Expression in Patients with PCOS Undergoing IVF/ICSI

et al. 2019

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To some extent, the use of metformin may improve endometrial receptivity and pregnancy outcomes of women with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection. However, the mechanism is not well-known. The endometrium of metformin-treated group (metformin-treated patients with PCOS) and the control group (non-metformin-treated patients with PCOS) were analyzed for the expression of homeobox A10 (HOXA10) and integrin beta-3 (ITGB3) and differential micro RNA (miRNA) expression profiles. On this basis, miRDB and Target Scan databases were used to predict and screen out that miR-491-3p and miR-1910-3p may target HOXA10 and ITGB3. Furthermore, we verified the effects of metformin on the expression of HOXA10 and ITGB3, and regulatory effects of miR-1910-3p and miR-491-3p on HOXA10 and ITGB3 using Ishikawa cell line. Metformin induced a significant dose-dependent upregulation of HOXA10 and ITGB3. The results from the microarray analyses showed there were 40 differentially expressed miRNAs between the 2 groups. Among them, miR-1910-3p and miR-491-3p were the 2 significantly downregulated miRNAs. Bioinformatics prediction indicated that HOXA10 and ITGB3 are potential target genes for miR-1910-3p and miR-491-3p. In Ishikawa cells transfected with miR-491-3p mimics, the expression of HOXA10 and ITGB3 on both messenger RNA (mRNA) and protein level were lower than those in control group ( P < .001). Also, the expression of HOXA10 mRNA and protein was lower in Ishikawa cells transfected with miR-1910-3p mimics ( P < .001). However, no significant changes in ITGB3 levels were observed in cells transfected with miR-1910-3p mimics ( P > .05). Metformin likely improves endometrial receptivity through downregulating the expression of miR-491-3p and miR-1910-3p, thereby increasing the expression of HOXA10 and ITGB3 in the endometrium of PCOS women.

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Section: Introductionmentioning

confidence: 99%

“…4 It is generally accepted that insulin resistance and secondary hyperinsulinemia have a pivotal role in the pathophysiology of PCOS. 5,6…”

Section: Introductionmentioning

confidence: 99%

Metformin Regulates Key MicroRNAs to Improve Endometrial Receptivity Through Increasing Implantation Marker Gene Expression in Patients with PCOS Undergoing IVF/ICSI

et al. 2019

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“…The association between IR and IH is not clear. Bonakdaran et al (25) did not find significant differences between the levels of serum insulin and the prevalence of IR in PCOS, IH, and healthy subjects, but Unlühizarci et al (26) found an association between IR and IH. In the present study, we did not find any association between IR and IH.…”

Section: Discussionmentioning

confidence: 96%

Depression, anxiety, and their relation with clinical parametersand androgen levels in hirsute women

Irak¹,

Yavuz²,

Doğan³

et al. 2016

Turk J Med Sci

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Background/aim: The purpose of this study was to assess the prevalence of anxiety and depression among patients with hirsutism and to evaluate the relationships of anxiety and depression with clinical parameters and androgen levels. Materials and methods:One hundred and seven women with hirsutism were enrolled in the study. All participants completed standardized questionnaires to assess depression (Beck Depression Inventory (BDI)) and anxiety (Beck Anxiety Inventory (BAI)). The Ferriman-Gallwey (FG) scores, body mass indexes (BMIs), homeostatic model assessments of insulin resistance (HOMA-IR), and serum androgen levels of all patients were obtained.Results: Seventy-four of the 107 patients (69.15%) had BDI scores indicating depression, and 47 of the 107 patients (43.9%) had BAI scores indicating anxiety disorders. No difference was found between high BAI and normal BAI patients related to BMI, age, FG scores, testosterone levels, and HOMA-IR levels (P > 0.05), and no difference was found between high BDI and normal BDI patients related to BMI, age, FG scores, free testosterone levels, and HOMA-IR levels. There was a positive correlation between BDI scores and dehydroepiandrosterone sulphate (DHEA-S) levels (P < 0.01). Conclusion:We found considerable amounts of depression, anxiety, and the coexistence of depression and anxiety in patients with hirsutism. Depression and the severity of depressive symptoms were positively correlated with DHEA-S levels.

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“…Insulin resistance is defined as a defect in glucose response to a specific amount of insulin. Insulin levels increase in circulation to maintain glucose levels to compensate for this deficiency in many of these patients [13]. There is a relationship between insulin resistance and coronary heart disease [14,15].…”

Section: Introductionmentioning

confidence: 99%

The Effect of 12 Weeks of Bariatric and Aerobic Exercises on Metabolic Syndrome Indices in Women

Sabzikar

Fathi

Darzabi

et al. 2018

PTJ

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Purpose: Osteoarthritis is a frequent complication in the middle-aged or older people. Besides pain and swelling, this disease causes deformity and difficulty in walking. The current study compared the effects of 12 weeks bariatric and aerobic exercises on the metabolic syndrome in women with knee osteoarthritis. Methods: In this quasi-experimental study, 24 women with knee osteoarthritis were selected by convenience sampling method. They were randomly divided into two groups of the bariatric (n=12) and aerobic (n=12) exercises. The training included aerobic and bariatric exercises at 60%-65% rate of the heart rate reserve. The program included a 12-week training, performed three times per week and each session lasted for 30 to 60 minutes. Intra-and inter-group comparisons were performed by dependent t-test and Analysis of Covariance (ANCOVA), respectively. The level of significance was set at P<0.05. Results: In both the aerobic and bariatric groups, 12 weeks of exercise program resulted in a significant reduction in weight, body mass index, serum glucose, insulin level, and insulin resistance index. Only in the aerobic exercise group, the concentrations of high-density lipoprotein, low-density lipoprotein, and total cholesterol significantly increased and decreased, respectively. The levels of triglyceride significantly decreased in both groups. Only in the aerobic exercise group, the maximum amount of oxygen consumption was significantly increased. Conclusion: In women with knee osteoarthritis, 12 weeks of aerobic and bariatric exercises positively affect the levels of insulin resistance markers, lipid profiles, and max-oxygen consumption. Therefore, these two exercise programs can be used to maintain health of these people.

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Evaluation of insulin resistance in idiopathic hirsutism compared with polycystic ovary syndrome patients and healthy individuals

Abstract: Insulin resistance was no more frequent in IH patients than in healthy control groups.

Cited by 10 publications

References 15 publications

Metformin Regulates Key MicroRNAs to Improve Endometrial Receptivity Through Increasing Implantation Marker Gene Expression in Patients with PCOS Undergoing IVF/ICSI

Metformin Regulates Key MicroRNAs to Improve Endometrial Receptivity Through Increasing Implantation Marker Gene Expression in Patients with PCOS Undergoing IVF/ICSI

Depression, anxiety, and their relation with clinical parametersand androgen levels in hirsute women

The Effect of 12 Weeks of Bariatric and Aerobic Exercises on Metabolic Syndrome Indices in Women

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