Evaluation of novel organosilane modifications of paper spray mass spectrometry substrates for analyzing polar compounds

Bambauer, Thomas P.; Maurer, Hans H.; Weber, Achim; Hannig, Matthias; Pütz, Norbert; Koch, Marcus; Manier, Sascha K.; Schneider, Marc; Meyer, Markus R.

doi:10.1016/j.talanta.2019.05.095

Cited by 10 publications

(7 citation statements)

References 39 publications

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“…In PS-MS, analytes are ionized from a paper tip by application of a solvent and an electric field, and thus it is one of the many variants of electrospray ionization . Importantly, paper can be readily modified to enhance PS-MS selectivity and sensitivity through surface modification or coating. − …”

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confidence: 99%

Rapid Distinction and Semiquantitative Analysis of THC and CBD by Silver-Impregnated Paper Spray Mass Spectrometry

et al. 2021

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The control over the amount of psychoactive THC (Δ-9-tetrahydrocannabinol) in commercial cannabidiol (CBD) products has to be strict. A fast and simple semiquantitative Ag(I)-impregnated paper spray mass spectrometric method for differentiating between THC and CBD, which show no difference in standard single-stage or tandem MS, was established. Because of a different binding affinity to Ag(I) ions, quasi-molecular Ag(I) adducts [THC + Ag] + and [CBD + Ag] + at m / z 421 and 423 give different fragmentation patterns. The product ions at m / z 313 for THC and m / z 353 and 355 for CBD can be used to distinguish THC and CBD and to determine their ratio. Quantification of THC/CBD ratios in commercial CBD oils was accomplished with a low matrix effect (−2.2 ± 0.4% for THC and −2.0 ± 0.3% for CBD). After simple methanol extraction (recovery of 87.3 ± 1.2% for THC and 92.3 ± 1.4% for CBD), Ag(I)-impregnated paper spray analysis was employed to determine this ratio. A single run can be completed in a few minutes. This method was benchmarked against the UHPLC-UV method. Ag(I)-impregnated paper spray MS had the same working range (THC/CBD = 0.001–1) as UHPLC-UV analysis ( R 2 = 0.9896 and R 2 = 0.9998, respectively), as well as comparable accuracy (−2.7 to 14%) and precision (RSD 1.7–11%). The method was further validated by the analysis of 10 commercial oils by Ag(I)-impregnated paper spray MS and UHPLC-UV analysis. Based on the determined relative concentration ratios of THC/CBD and the declared CBD concentration, 6 out of 10 CBD oils appear to contain more THC than the Dutch legal limit of 0.05%.

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confidence: 99%

Rapid Distinction and Semiquantitative Analysis of THC and CBD by Silver-Impregnated Paper Spray Mass Spectrometry

et al. 2021

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“…Generally, for a liquid-phase silanization reaction, the surface to be silanized is immersed in a solution of hexane containing the organosilane with concentrations ranging from 0.1 to 2 (v/v). After the reaction, the surface must be washed several times with different solvents, such as hexane and methanol, to remove the residual unreacted reagent. − Liquid-phase reactions can form agglomerates instead of a monolayer during the silanization process, leading to a nonuniform coverage of the solid surface and an irreproducible paper modification . The type of organosilane reagent available is limited to the compatibility with the solvent used in each step of the fabrication .…”

Section: Resultsmentioning

confidence: 99%

Direct Analysis of Doping Agents in Raw Urine Using Hydrophobic Paper Spray Mass Spectrometry

Rossini

Kulyk

Ansu-Gyeabourh

et al. 2020

J. Am. Soc. Mass Spectrom.

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In this study, the direct analysis of doping agents in urine samples with no sample preparation by a modified paper spray mass spectrometry (PS-MS) methodology has been demonstrated for the first time. We have described a paper surface treatment with trichloromethylsilane using a gas-phase reaction to increase the ionization of target compounds. This approach was applied for the analysis of two classes of banned substances in urine samples: anabolic agents (trenbolone and clenbuterol) and diuretics (furosemide and hydrochlorothiazide). Under optimized conditions, the developed methods presented satisfactory repeatability, and an analysis of variance showed linearity without lack-of-fit. Highly sensitive detections as low as sub-nanogram per milliliter levels, which is below the minimum required performance levels proposed by the World Anti-Doping Agency, have been reached using the hydrophobic PS-MS analysis without any preconcentration and cleanup step.

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“…The authors observed a considerably superior detection capability for some toxic compounds, for instance, orellanine. 14 Bin and co-workers recently introduced a related technique. The authors used wooden toothpicks for matrixes that PS-MS cannot directly analyze such as pasty and difficult-to-collect samples.…”

Section: ■ Introductionmentioning

confidence: 99%

“…For instance, Bambauer and co-workers evaluated paper substrates modified by depositing different organosilanes to analyze polar toxins. The authors observed a considerably superior detection capability for some toxic compounds, for instance, orellanine …”

Section: Introductionmentioning

confidence: 99%

Sandpaper: Efficient Medium for Analysis of Polishable Solid Samples by Ambient Mass Spectrometry

Santos

Costa

Almeida

et al. 2023

J. Am. Soc. Mass Spectrom.

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In this paper, we employed sandpaper as an efficient medium to analyze polishable solid samples. As proof of principle, the surfaces of coffee beans were sanded with pieces of sandpaper cut into a triangular shape. The triangle was placed in front of the mass spectrometer inlet, and methanol was dropped on its surface. After a high-voltage application, the fingerprints of the coffee beans (n = 100) were achieved in the positive and negative ion modes in an identical procedure employed for paper spray mass spectrometry (PS-MS) analysis. The new methodology, named sandpaper spray mass spectrometry (SPS-MS), allowed for identifying many compounds in coffee beans, mainly caffeine, sugars, and carboxylic acids, among other molecules. The new technique shows advantages over PS-MS in analyzing polishable solid samples. Furthermore, compared to the direct analysis of tissues such as leaves, grains, and seeds, in which the pieces must be cut in a triangular shape (a difficult task depending on the samples′ hardness), the SPS-MS technique is much more straightforward. Finally, SPS-MS can be potentially applied to analyze other hard surfaces such as wood, plastic, and assorted crop grains.

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Evaluation of novel organosilane modifications of paper spray mass spectrometry substrates for analyzing polar compounds

Cited by 10 publications

References 39 publications

Rapid Distinction and Semiquantitative Analysis of THC and CBD by Silver-Impregnated Paper Spray Mass Spectrometry

Rapid Distinction and Semiquantitative Analysis of THC and CBD by Silver-Impregnated Paper Spray Mass Spectrometry

Direct Analysis of Doping Agents in Raw Urine Using Hydrophobic Paper Spray Mass Spectrometry

Sandpaper: Efficient Medium for Analysis of Polishable Solid Samples by Ambient Mass Spectrometry

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