Evaluation of the Black Cumin Seed Oil Role (BCSO) on a Decline in eNOS Expression and Plasma NO Levels: Initial Studies Kemopreventive BCSO for Lung Cancer

Hidayati, Titiek; Akrom,; Indrayanti, Indrayanti; Sagiran,

doi:10.17706/ijbbb.2017.7.3.162-168

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…The BCSO group of 6.8 mg/kg BW/day was able to improve the immune response to the same level as the BCSO group of 68 and 136 mg/kg BW/day and may be safer with smaller doses. The results of this study are consistent with previous studies showing that BCSO is both antioxidative and immunomodulatory [16][17][20][21][22]. Data from this study support the results of previous studies, namely the effect of BCSO on the number of CD4CD25Treg.…”

Section: Number Of Cd4 Th and Cd4cd25 Tregsupporting

confidence: 92%

“…As CD4 Th increases, the production of IL-2, IL-12 and IFN-y cytokines also increases, thus increasing the number and activity of CD8 cytolytic lymphocytes [8]. It has been demonstrated that BCSO decreases eNOS activity, lymphocyte proliferative activity and differentiation increases the production of IL-12 cytokines by macrophages and inhibits inflammation through inhibition of prostaglandin production [15,[21][22]24].…”

Section: Number Of Cd4 Th and Cd4cd25 Tregmentioning

confidence: 99%

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Black cumin seed oil increase leucocyte and CD4Thelper number in sprague-dawley rats induced with dimethylbenzanthracene

Hidayati

Akrom

Indrayanti

et al. 2019

IJPHS

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<p>Cigarette smoke contains 7, 12 dimethylbenzanthracene (DMBA). Metabolic of DMBA is immunosuppressive. Black cumin seed oil (BCSO) is an immunomodulation. The aim of this study was to determine the effect of BCSO on leukocyte, CD4Th and CD4CD25Treg in Sprague-Dawley (SD) mice induced with DMBA. The 96 SD rats were divided into 8 groups of 12. Group I received aquabidest and standard feeding. Groups II, III and IV received BCSO (an equivalent of 6.8, 68 and 136 mg/kg BW / day thymoquinone, respectively). Group V received thymoquinone (50 mg / kg BW / day) and group VI received tamoxifen (60 mg / kg BW). Group VII (DMBA) was induced with DMBA (10x20mg / kg BW for 5 weeks). Group VIII received standard feeding and corn oil treatment. In the third week, all groups began to be induced with DMBA (20 mg/kg BW twice per week for five weeks). Data collection of leukocytes, CD4Th and CD4CD25Treg was performed at week 27th. The mean difference of CD4Th and CD4CD25Treg counts between groups was calculated with one way ANOVA. Results: The administration of BCSO, thymoquinone, and tamoxifen had increased leukocytes and CD4 Th cell count. The CD4Th cell count of the treatment groups was higher than that of the DMBA group (p <0.05). BCSO equivalent doses of 6.8 and 68 mg/kg BW / day thymoquinone showed immunoprotective effects. Conclusion: It can be concluded that the BCSO administration at doses of 6.8 and 68 mg/kg BW / day shows immunoprotective effects due to DMBA induction.</p>

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Section: Number Of Cd4 Th and Cd4cd25 Tregsupporting

confidence: 92%

Section: Number Of Cd4 Th and Cd4cd25 Tregmentioning

confidence: 99%

Black cumin seed oil increase leucocyte and CD4Thelper number in sprague-dawley rats induced with dimethylbenzanthracene

Hidayati

Akrom

Indrayanti

et al. 2019

IJPHS

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“…2, April 2022: 1565-1570 1566 homeostasis of blood vessels. Disruption of endothelial homeostasis causes the impaired function of nitric oxide synthase (NOS) so that the production of nitric oxide (NO) compounds, which play an essential role in regulating blood flow, is reduced [20].…”

Section: Introductionmentioning

confidence: 99%

Poincaré plots to analyze photoplethysmography signal between non-smokers and smokers

Haryadi

Chang

Akrom

et al. 2022

IJECE

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<span>An analysis of blood circulation was used to identify variations of heart rate and to create an early warning system of autonomic dysfunction. The Poincaré plot analyzed blood circulation using photoplethysmography (PPG) signals between non-smokers and smokers in three different indices: SD1, SD2, and SD1 SD2 ratio (SSR). There were twenty subjects separated into non-smoker and smoker groups with sample sizes of 10, respectively. An independent sample t-test to compare the continuous variables. Whereas, the comparison between two groups employed Fisher’s exact test for categorical variables. The result showed that SD1 was found to be considerably lower in the group of smokers (0.03±0.01) than that of the non-smokers (0.06±0.03). Similarly, SSR was recorded at 0.0012±0.0005 and 0.0023±0.0012 for smoking and non-smoking subjects, respectively. As a comparison, SD2 for non-smokers (25.7±0.5) was lower than smokers (27.3±0.4). In conclusion, we revealed that the parameters of Poincaré plots (SD1, SD2, and SSR) exert good performances to significantly differentiate the PPG signals of the group of non-smokers from those of smokers. We also supposed that the method promises to be a suitable method to distinguish the cardiovascular disease group. Therefore, this method can be applied as a part of early detection system of cardiovascular diseases.</span>

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“…Some medicinal plants can be used to prevent cardiovascular and degenerative diseases, cancer, diabetes mellitus, and aging/senility [11], [12]. These plants have shown antioxidative [13], immunomodulatory [14], antihypertensive [15], antibacterial, hypoglycemic [16], anti-dyslipidemic, cytotoxic, and antiproliferative activities [17]. Transforming the plants into medicinal preparations in herbs and standardized herbal medicines will increase their use-value and economic value.…”

Section: Introductionmentioning

confidence: 99%

The Potential of Centella asiatica Herb and Cyperus rotundus L. Rhizomes Extract as a Chemoprevention Agent for Lung Cancer

Indrayanti

Hidayati²,

Setyanto³

2022

Open Access Maced J Med Sci

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BACKGROUND: The number of smokers is increasing in Indonesia. Cigarette smoke can cause many diseases, such as lung cancer. Centella asiatica (CAS) and Cyperus rotundus L. rhizomes (CRR) exhibit anti-cancer effects. AIM: The study examined the cytotoxic effects of CRR and CAS extracts in lung cancer cells. METHODOLOGY: This research used the maceration method to extract the CAS and CRR powder and methanol solvent. Extraction was tested at 600μl, 400μl, 200 μl, 100 μl, and 50 μl to determine the effect of compound cytotoxicity causing 50% cell death or IC50. Cytotoxicity tests used the MTT method to obtain purple formation crystals and used an ELISA reader to obtain absorbance values. RESULTS: CRR and CAS extract shows a low cytotoxicity effect. IC50 of CRR and CAS methanol extracts was 235 μg/ml and 279 μg/ml, respectively. CONCLUSION: CRR and CAS extracts were proven to show chemopreventive activities against lung cancer cells.

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Evaluation of the Black Cumin Seed Oil Role (BCSO) on a Decline in eNOS Expression and Plasma NO Levels: Initial Studies Kemopreventive BCSO for Lung Cancer

Cited by 4 publications

References 18 publications

Black cumin seed oil increase leucocyte and CD4Thelper number in sprague-dawley rats induced with dimethylbenzanthracene

Black cumin seed oil increase leucocyte and CD4Thelper number in sprague-dawley rats induced with dimethylbenzanthracene

Poincaré plots to analyze photoplethysmography signal between non-smokers and smokers

The Potential of Centella asiatica Herb and Cyperus rotundus L. Rhizomes Extract as a Chemoprevention Agent for Lung Cancer

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