Evaluation of the effect of Spirulina against Gamma irradiation induced oxidative stress and tissue injury in rats

Abstract

doi:10.6088/ijaser.0020101016 Abstract: Many antioxidants have been investigated as hepato-protectors against ionizing radiation induced injury since they reduce the oxidative effect of the reactive oxygen species on normal cells. Spirulina is a potent scavenger of a variety of free radicals. The aim of this study was to investigate the radio-protective effect of Spirulina algae against oxidative stress and tissue injury caused by gamma radiation. Rats were irradiated at two doses of 2 and 4Gy from cesium-137 source. Ten days prior to irradiation, animals received Spirulina daily (300mg/kg body weight i.p.). In the irradiated animal group, the oxidative stress markers malondialdehyde (MDA) was significantly increased in the liver, while a marked decrease in hepatic contents of DNA, and glutathione (GSH).The level of cholesterol, triglyceride (TG), low density lipoprotein (LDL), as well as activitiy of aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT), were significantly increased in sera of the irradiated rats. This was coupled with a decreased serum level of high-density lipoprotein (HDL) and total serum protein by irradiation. The administration of Spirulina alone daily for 10 days caused a significant decrease in MDA and produced significant elevation of liver GSH. Moreover, a significant decrease occurred in cholesterol, and TG level with no change in serum LDL or HDL levels in serum. Treatment o

Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats

“…Comparisons were made as follows: a group I vs groups II, III, IV, V; b group II vs group III, IV, V; c group III vs group IV, V; d group IV vs group V. The symbols represent statistical significance at *P < 0.05. Statistical analysis was calculated by one-way ANOVA followed by the Student Newman-Keul's test ionizing-radiation induced oxidative stress and organ injury (Rehab 2012). A study on Spirulina maxima has reported to show protection against hepatotoxic, hyperglycaemic and hyperlilidaemic activity, which was analyzed on fructose-induced diabetic rats (Jarouliya et al 2012).…”

The curative effect of Bee Venom and Propolis on oxidative stress induced by γ-irradiation on blood and tissues of rats

“…Animals were placed in a specially designed well-ventilated acrylic container and the whole body of the animals were exposed to 5 Gy as a single shot dose, given at a dose rate of 0.84 Gy/min from the biological irradiator gamma cell-40, cesium-137 source (Atomic Energy Agency, Canada Limitd, AECL), belonging to National Center for Radiation Research and Technology (NCRRT), Cairo (Rehab and Ibrahim, 2012).…”