Evaluation of the Performance Characteristics of the PC 4600 Positron Emission Tomograph

Kearfott, Kimberlee J.; Carroll, Liam

doi:10.1097/00004728-198406000-00027

Cited by 42 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tb account more specifically for the possible effects on CBF of hypocapnia resulting from anxiety-induced hyperventilation, global and regional CBF values were also analyzed after normalization to the predicted flow for a Paco2 value of 40 mm Hg through application of the experimentally established equation for CBF as a function of Paco2: CBF = 1.8-Paco2- 16 Similarly, CBF measurements were also analyzed by a repeatedmeasures analysis of covariance to determine the effects on CBF specific to anxiety, while factoring out possible individual contribu¬ tions of Paco2, HR, or MAP. Additionally, correlational analyses between anxiety, and absolute and Paco2-corrected CBF values were performed by the use of canonical and simple linear and second-order models.22 Student's t test for two independent samples was employed for comparison between the resting regional and global CBF values of the phobia subjects and normal controls.…”

Section: Methodsmentioning

confidence: 99%

Positron Emission Tomographic Evaluation of Cerebral Blood Flow During State Anxiety in Simple Phobia

Mountz

Modell

Wilson

et al. 1989

Arch Gen Psychiatry

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Positron Emission Tomographic Evaluation of Cerebral Blood Flow During State Anxiety in Simple Phobia

Mountz

Modell

Wilson

et al. 1989

Arch Gen Psychiatry

View full text Add to dashboard Cite

“…Other corrections, e.g., rand oms and deadtime, were applied as described for the PC4600 PET scanner by Kearfott and Carroll (1984). This standard reconstruction protocol was applied to all "functionalized" FDQ/PET scans 45-55 min postinjec tion.…”

Section: Reconstruction Parametersmentioning

confidence: 99%

Absolute Quantitation in Neurological PET: Do We Need it?

Strother

Liow

Moeller

et al. 1991

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Summary: This article addresses the question posed in the title by examining the effects of parameters tradition ally associated with improved absolute quantitation, on the analysis of 12 acquired immune deficiency syndrome dementia complex (ADC) patients compared to a normal control group. Results are discussed within the frame work of the subprofile scaling model (SSM) for analyzing patterns of regional covariation. It is demonstrated that the ability to extract measures of group discrimination and disease progression are unaffected by (1) limited improvements in image resolution, (2) the use of trans mission scan smoothing, (3) the application of a scatter deconvolution correction, and (4) converting region-Of interest measurements of counts per voxel to mea surements of regional CMRg!c. This "robustness" of the ---_ .--. __ ..

show abstract

“…Measured attenuation with rod source (Kearfott and Carroll, 1984). A rod source of � 1 mCi 68-Ge/68-Ga was mounted on a rotating source holder at the edge of the field of view (POV).…”

Section: Measurementsmentioning

confidence: 99%

Assessment of Accuracy of PET Utilizing a 3-D Phantom to Simulate the Activity Distribution of [¹⁸F]Fluorodeoxyglucose Uptake in the Human Brain

Hoffman¹,

Cutler²,

Guerrero³

et al. 1991

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Summary: A three-dimensional brain phantom has been developed to simulate the activity distributions found in human brain studies currently employed in positron emis sion tomography (PET). The phantom has a single con tiguous chamber and utilizes thin layers of lucite to pro vide apparent relative concentrations of 5, 1, and 0 for gray matter, white matter, and CSF structures, respec tively. The phantom and an ideal image set were created from the same set of data. Thus, the user has a basis for comparing measured images with an ideal set that allows a quantitative evaluation of errors in PET studies with an activity distribution similar to that found in patients. ThePositron emission tomography (PET) has often been cited as a technique capable of making quan titative "in vivo" measurements of metabolic or physiologic quantities in humans (Greitz et aI., 1984; Phelps et aI., 1986). The measurements usu ally require the following: (a) a detailed understand ing of the biological process under study; (b) a mathematical model of the process; (c) a series of blood samples for the time course of activity in the blood, and possibly some chemical analysis; (d) a reasonably cooperative patient, who will remain still for 20-200 min, depending upon the study; and (e) a PET system that is sufficiently characterized to make a quantitative measurement. All are re quired for a quantitative measurement. The topic of Al7phantom was employed in a study of the effect of dead time and scatter on accuracy in quantitation on a current PET system. Deadtime correction factors were found to be significant (1.1-2.5) at count rates found in clinical studies. Deadtime correction techniques were found to be accurate to within 5%. Scatter in emission and attenua tion correction data consistently caused 5-15% errors in quantitation, whereas correction for scatter in both types of data reduced errors in accuracy to <5%. Key Words: Positron emission tomography-Brain phantom Error -Dead time-Scatter . this work is the accuracy of the PET system itself, without the complications of the first four points in this list.

show abstract

Evaluation of the Performance Characteristics of the PC 4600 Positron Emission Tomograph

Cited by 42 publications

References 0 publications

Positron Emission Tomographic Evaluation of Cerebral Blood Flow During State Anxiety in Simple Phobia

Positron Emission Tomographic Evaluation of Cerebral Blood Flow During State Anxiety in Simple Phobia

Absolute Quantitation in Neurological PET: Do We Need it?

Assessment of Accuracy of PET Utilizing a 3-D Phantom to Simulate the Activity Distribution of [¹⁸F]Fluorodeoxyglucose Uptake in the Human Brain

Contact Info

Product

Resources

About

Evaluation of the Performance Characteristics of the PC 4600 Positron Emission Tomograph

Cited by 42 publications

References 0 publications

Positron Emission Tomographic Evaluation of Cerebral Blood Flow During State Anxiety in Simple Phobia

Positron Emission Tomographic Evaluation of Cerebral Blood Flow During State Anxiety in Simple Phobia

Absolute Quantitation in Neurological PET: Do We Need it?

Assessment of Accuracy of PET Utilizing a 3-D Phantom to Simulate the Activity Distribution of [18F]Fluorodeoxyglucose Uptake in the Human Brain

Contact Info

Product

Resources

About

Assessment of Accuracy of PET Utilizing a 3-D Phantom to Simulate the Activity Distribution of [¹⁸F]Fluorodeoxyglucose Uptake in the Human Brain