Evaluation of the radiopacity and cytotoxicity of Portland cements containing bismuth oxide

Kim, Eun-Cheol; Lee, Byung-Cheon; Chang, Hoon-Sang; Lee, Wan; Hong, Chan-Ui; Min, Kyung-San

doi:10.1016/j.tripleo.2007.08.001

Cited by 87 publications

(89 citation statements)

References 19 publications

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“…Bismuth oxide and other bismuth-based compounds are also known to be biocompatible [14]. They have been extensively used in many medical and cosmetic applications for many years [15]. In addition, Stewart et al [16] showed that bismuth oxide nanoparticles could be tailored with different oxygen contents, inducing cell proliferation or toxicity.…”

Section: Introductionmentioning

confidence: 99%

First proof of bismuth oxide nanoparticles as efficient radiosensitisers on highly radioresistant cancer cells

et al. 2016

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This study provides the first proof of the novel application of bismuth oxide as a radiosensitiser. It was shown that on the highly radioresistant 9L gliosarcoma cell line, bismuth oxide nanoparticles sensitise to both kilovoltage (kVp) or megavoltage (MV) X-rays radiation. 9L cells were exposed to a concentration of 50 μg.mL −1 of nanoparticle before irradiation at 125 kVp and 10 MV. Sensitisation enhancement ratios of 1.48 and 1.25 for 125 kVp and 10 MV were obtained in vitro, respectively. The radiation enhancement of the nanoparticles is postulated to be a combination of the high Z nature of the bismuth (Z = 83), and the surface chemistry. Monte Carlo simulations were performed to elucidate the physical interactions between the incident radiation and the nanoparticle. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64

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Section: Introductionmentioning

confidence: 99%

First proof of bismuth oxide nanoparticles as efficient radiosensitisers on highly radioresistant cancer cells

et al. 2016

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“…However, bismuth oxide is known to retard hydration, prolong setting time, and reduce the mechanical strength and durability of the resulting cement matrix 25,26) . Furthermore, the presence of bismuth oxide has been reported to exhibit initial toxicity towards human dental pulp cells and human periodontal ligament cells 23,24) . Alternative radiopacifying agents with superior physicochemical and biological properties are currently under consideration.…”

Section: Discussionmentioning

confidence: 99%

“…In common with MTA, it contains bismuth oxide to provide radiopacity. Although bismuth oxide provides sufficient radiopacity, there are several reports showing that it has harmful effects stemming from its biological and mechanical properties [23][24][25][26] . Among possible alternatives to bismuth oxide, zirconium oxide (ZrO 2) was investigated as a candidate because of its adequate radiopacity and cost-effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Odontogenic effects of a fast-setting calcium-silicate cement containing zirconium oxide

et al. 2015

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A fast-setting calcium-silicate cement (Endocem) was introduced in the field of dentistry for use in vital pulp therapy. Similar to mineral trioxide aggregate (MTA), it contains bismuth oxide to provide radiopacity. Recently, another product, EndocemZr, which contains zirconium oxide (ZrO2) as a radiopacifier, was developed by the same company. In this study, the biological/odontogenic effects of EndocemZr were investigated in human primary dental pulp cells (hpDPCs) in vitro and on capped rat teeth in vivo. The biocompatibility of EndocemZr was similar to that of ProRoot and Endocem on the basis of cell viability tests and cell morphological analysis. The mineralization nodule formation, expression of odontogenic-related markers, and reparative dentin formation of EndocemZr group was similar to those of other material groups. Our results suggest that EndocemZr has the potential to be used as an effective material for vital pulp therapy, similar to ProRoot and Endocem.

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“…Portland cement and MTA have similar major constituents, except for bismuth oxide, which is added to MTA to provide radiopacity (11,26,27). Although this feature does not compromise the execution of pulpotomy procedures with PC and their follow-up assessments, this property is necessary in order to distinguish the material from surrounding anatomical structures such as tooth and bone (11,17,18,28), and to permit the material to achieve the minimum values recommended by the American National Standards Institute / American Dental Association (ANSI/ADA) standard No 57/2000 (29).…”

Section: Discussionmentioning

confidence: 99%

“…Portland cement (PC) has emerged as an alternative to MTA because of its relative lower cost, similar chemical composition and biocompatibility with MTA, and several studies have compared both materials (12)(13)(14)(15)(16). As PC may potentially be used as an endodontic material (11,17), it does not have sufficient radiopacity to be visualized radiographically, and therefore a radiopacifying agent must be added to it (11).…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of Portland cement combined with different radiopacifying agents

et al. 2014

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The aim of this study was to evaluate the response of rat subcutaneous tissue to Portland cement combined with two different radiopacifying agents, iodoform (CHI 3 ) and zirconium oxide (ZrO 2 ). These materials were placed in polyethylene tubes and implanted into the dorsal connective tissue of Wistar rats for 7 and 15 days. The specimens were then stained with hematoxylin and eosin, and inflammatory reaction parameters were evaluated by light microscopy. The intensity of the inflammatory response to the sealants was analyzed by two blind calibrated observers throughout the experimental period. Histological analysis showed that all the materials caused a moderated inflammatory reaction at 7 days, which then diminished with time. At 15 days, the inflammatory reaction was almost absent, and fibroblasts and collagen fibers were observed indicating normal tissue healing. The degrees of the inflammatory reaction on different days throughout the experimental period were compared using the non-parametric Kruskal-Wallis test. Statistical analysis demonstrated no significant differences amongst the groups, and Portland cement associated with radiopacifying agents gave satisfactory results. Therefore, Portland cement used in combination with radiopacifying agents can be considered a biocompatible material. Although our results are very encouraging, further studies are needed in order to establish safe clinical indications for Portland cement combined with radiopacifying agents. (J Oral Sci 56, 29-34, 2014)

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Evaluation of the radiopacity and cytotoxicity of Portland cements containing bismuth oxide

Cited by 87 publications

References 19 publications

First proof of bismuth oxide nanoparticles as efficient radiosensitisers on highly radioresistant cancer cells

First proof of bismuth oxide nanoparticles as efficient radiosensitisers on highly radioresistant cancer cells

Odontogenic effects of a fast-setting calcium-silicate cement containing zirconium oxide

Biocompatibility of Portland cement combined with different radiopacifying agents

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