Evidence for a Physiological Role of Angiotensin-(1-7) in the Control of Hydroelectrolyte Balance

Santos, Robson Augusto Souza; Silva, A. C. Simoes E; Magaldi, Antonio J.; Khosla, M. C.; Cesar, Katia R.; Passaglio, Kátia Tomagnini; Baracho, N.C.V.

doi:10.1161/01.hyp.27.4.875

Cited by 98 publications

(129 citation statements)

References 34 publications

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“…13 Ang-(1-7) also demonstrates effects on renal function by participating in the control of water and electrolyte homeostasis. 14 However, research involving Ang-(1-7) is not restricted to cardiovascular and renal function. In recent years, investigations have demonstrated Ang-(1-7)-dependent effects on wound healing, 15 mechanisms involved in learning and memory, 16 cancer [17][18][19] and early progenitor cells.…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors

et al. 2012

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The renin-angiotensin system (RAS) has a vital role in regulating the cardiovascular system. The primary effector of the RAS is the octapeptide angiotensin (Ang) II, a potent regulator of blood pressure and water homeostasis. Ang II mediates its functions through the stimulation of two distinct receptors, AT 1 (two subtypes in rodents (AT 1a and AT 1b )) and AT 2 . It was shown that in addition to Ang II, shorter fragments of Ang are also biologically active. Ang-(1-7) came into focus because it opposes many of the detrimental effects of Ang II. However, it is still controversial whether Ang II receptors are involved in Ang-(1-7)-mediated signaling. To characterize the impacts of Ang II receptors on Ang-(1-7)-stimulated vascular relaxation, the effects of acute infusion of the three vasorelaxant compounds, that is, Ang-(1-7), bradykinin (BK) and acetylcholine (ACh), on heart rate (HR) and mean arterial pressure (MAP) were investigated in mice deficient for one, two or all three Ang II receptors. Ang-(1-7) and BK reduced MAP in wild-type, AT 1a /AT 1b -deficient and AT 2 -deficient mice. Although the change in absolute MAP values in the hypotensive triple knockouts (KO) could not be further reduced by both peptides, the percent change in MAP was comparable between the triple KO and wild-type mice. Both peptides did not alter the HR in all four genotypes. ACh significantly reduced absolute MAP values in all four genotypes with a similar percentage of reduction. In contrast to Ang-(1-7) and BK, ACh significantly reduced HR without genotypic differences. Our results generate proof that Ang-(1-7)-induced effects on MAP are mediated by a receptor that is independent of AT 1 and AT 2 .

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Section: Introductionmentioning

confidence: 99%

Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors

et al. 2012

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“…However, due to several factors discussed below there is no consensus regarding the major action of Ang-(1-7) in the kidney. Several studies suggest a major role of Ang-(1-7) as a natriuretic peptide (16)(17)(18) while other studies, including ours, point to a major role of this angiotensin in water transport (19)(20)(21)(22). It should be pointed out, however, that, even when apparently contradictory, these studies clearly show that the renal ac-tions of Ang-(1-7) are very complex, apparently involving both the proximal and distal nephron as is also the case for Ang II.…”

Section: Introductionmentioning

confidence: 99%

Renal actions of angiotensin-(1-7)

Silva¹,

Baracho²,

Passaglio³

et al. 1997

Braz J Med Biol Res

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The heptapeptide angiotensin-(1-7) is considered to be a biologically active endproduct of the renin-angiotensin system. This angiotensin, which is devoid of the most known actions of angiotensin II such as induction of drinking behavior and vasoconstriction, has several selective effects in the brain and periphery. In the present article we briefly review recent evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance.

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“…However, ANG-(1-7) also induced antidiuresis in water-loaded rodents (258) and increased renal tubular sodium reabsorption in rats [176]. In addition, in normal and hypertensive rats [177] and in water-loaded [178] or virgin female rats [179], ANG-(1-7) had an antidiuretic effect that was mediated, at least in part, by the Mas receptor. Furthermore, in SpragueDawley rats, the administration of ANG-(1-7) resulted in antidiuresis that was associated with an upregulation in renal aquaporin-1 [180], and in isolated rat inner medullary collecting duct cell suspensions, ANG-(1-7) (10 −9 M) increased cAMP production [181], a response that was attenuated by Mas receptor antagonists and the pharmacological blockade of the AVP V2 receptor.…”

Section: Actions Of Ang-(1-7) In the Kidneymentioning

confidence: 99%

ANG II, ANG-(1-7), ALDO and AVP biphasic effects on Na+/H+ transport: the role of cellular calcium

Mello-Aires¹,

Dellova²,

Castelo‐Branco³

et al. 2017

Nephrol Renal Dis

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This article reviews the main body of knowledge regarding NHE1 and NHE3 exchangers and their interaction with Angiotensin II, Angiotensin-(1-7), Aldosterone and Arginine Vasopressin, particularly their renal actions. This work addresses the biphasic effects of different hormonal doses on NHE1 or NHE3 in proximal tubule in Wistar, SHR (hypertensives) and their control WKY (normotensives) rats or MDCK cells (which share similarities with the collecting duct). The hormones were applied alone, with their inhibitors or plus agents that change the [Ca 2+ ]i. The data are compatible with hormonal stimulation of these exchangers by increases of [Ca 2+ ]i in lower range, and inhibition at high [Ca 2+ ]i. In MDCK cells and Wistar rats, low doses of ANG II, ALDO or AVP stimulated the exchangers, while high doses inhibited them. ANG-(1-7), in Wistar or WKY rats has inverse, dose-dependent effects. In SHR rats, the biphasic effects of ANG-(1-7) were similar to the effects of ANG II, ALDO or AVP in Wistar rats. The interactions between these effects may represent a mechanism that regulates extracellular volume. In hypertensives animals, a high plasma level of ANG-(1-7) inhibited NHE3 in the proximal tubule, which mitigated hypertension. Figure 6 shows a schematic model to describe these biphasic hormonal effects.

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Evidence for a Physiological Role of Angiotensin-(1-7) in the Control of Hydroelectrolyte Balance

Cited by 98 publications

References 34 publications

Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors

Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors

Renal actions of angiotensin-(1-7)

ANG II, ANG-(1-7), ALDO and AVP biphasic effects on Na+/H+ transport: the role of cellular calcium

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