Examining the relationships between prenatal methamphetamine exposure, early adversity, and child neurobehavioral disinhibition.

Abar, Beau; LaGasse, Linda L.; Derauf, Chris; Newman, Elana; Shah, Rizwan; Smith, Lynne M.; Arria, Amelia M.; Huestis, Marilyn A.; Grotta, Sheri Della; Dansereau, Lynne M.; Neal, Charles R.; Lester, Barry M.

doi:10.1037/a0030157

Cited by 38 publications

(32 citation statements)

References 78 publications

(140 reference statements)

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“…During infancy, the IDEAL study reported PME effects on poor fine motor performance, decreased arousal, and increased stress. 11 In 3–6.5 year-olds, PME was associated with executive function deficits 12 and behavior problems, including increased emotional reactivity, anxiousness, depressiveness, attention problems, withdrawn behavior, 13 and poor inhibitory control. 14 …”

Section: Introductionmentioning

confidence: 99%

Risk of Neurobehavioral Disinhibition in Prenatal Methamphetamine–Exposed Young Children With Positive Hair Toxicology Results

Himes

LaGasse

Derauf

et al. 2014

Therapeutic Drug Monitoring

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Background The objective was to evaluate effects of prenatal methamphetamine exposure (PME) and postnatal drug exposures identified by child hair analysis on neurobehavioral disinhibition at 6.5 years of age. Methods Mother-infant pairs were enrolled in the Infant Development, Environment, and Lifestyle (IDEAL) Study in Los Angeles, Honolulu, Tulsa and Des Moines. PME was determined by maternal self-report and/or positive meconium results. At the 6.5-year follow-up visit, hair was collected and analyzed for methamphetamine, tobacco, cocaine, and cannabinoid markers. Child behavioral and executive function test scores were aggregated to evaluate child neurobehavioral disinhibition. Hierarchical linear regression models assessed the impact of PME, postnatal substances, and combined PME with postnatal drug exposures on the child’s neurobehavioral disinhibition aggregate score. Past year caregiver substance use was compared to child hair results. Results A total of 264 children were evaluated. Significantly more PME children (n=133) had hair positive for methamphetamine/amphetamine (27.1% versus 8.4%) and nicotine/cotinine (38.3% versus 25.2%) than children without PME (n=131). Overall, no significant differences in analyte hair concentrations were noted between groups. Significant differences in behavioral and executive function were observed between children with and without PME. No independent effects of postnatal methamphetamine or tobacco exposure, identified by positive hair test, were noted and no additional neurobehavioral disinhibition was observed in PME children with postnatal drug exposures, as compared to PME children without postnatal exposure. Conclusions Child hair testing offered a non-invasive means to evaluate postnatal environmental drug exposure, although no effects from postnatal drug exposure alone were seen. PME, alone and in combination with postnatal drug exposures, was associated with behavioral and executive function deficits at 6.5 years.

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Section: Introductionmentioning

confidence: 99%

Risk of Neurobehavioral Disinhibition in Prenatal Methamphetamine–Exposed Young Children With Positive Hair Toxicology Results

Himes

LaGasse

Derauf

et al. 2014

Therapeutic Drug Monitoring

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“…These findings are consistent with previous work that demonstrated PME and early adversity were associated with behavioral and emotional control issues at age 5 years. [11]…”

Section: Discussionmentioning

confidence: 99%

“…putamen, globus pallidus, hippocampus, and caudate) with memory and attention deficits among children with PME from 3-16 years old[30]. In previous findings from the IDEAL study, Abar et al[11] examined the extent to which PME was predictive of childhood neurobehavioral disinhibition (ND) and the extent to which early adversity (birth through year 3) mediated this process. At age 6.5 years of age PME was associated with issues regarding behavioral and emotional control at 5 years of age, which was associated with executive function deficits at 6.5 years.…”

Section: Discussionmentioning

confidence: 99%

“…Previous work seeking to determine the extent early adversity mediated the relationship between PME and neurobehavioral disinhibition[9] utilized an early adversity index score created using data collected on the children and families between 0 and 3 years of age. Initial work using this adversity index score reported PME was predictive of childhood neurobehavioral disinhibition with early adversity mediating this relationship.…”

mentioning

confidence: 99%

“…Specifically, emotional regulation and behavior control issues at age 5 years and deficits in executive cognitive functioning at age 6.5 years [10] associated with PME was mediated by early adversity. [11] Additionally, the question of other predictors of gains in neurodevelopmental outcomes remains. Manley et al[12] evaluated cognitive scores in infants from the Caffeine for Apnea of Prematurity Study (CAP Study) at 18 months and 5 years.…”

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confidence: 99%

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School-Aged Outcomes following Prenatal Methamphetamine Exposure: 7.5-Year Follow-Up from the Infant Development, Environment, and Lifestyle Study

Eze

Smith

LaGasse

et al. 2016

The Journal of Pediatrics

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Objective To assess the relationship between prenatal methamphetamine exposure (PME) and behavior problems at age 7.5 years, and the extent to which early adversity mediated this relationship. Study design The multicenter, longitudinal IDEAL study enrolled 412 mother-infant pairs at 4 sites. Methamphetamine-exposed participants (n= 204) were identified by self-report and/or gas chromatography/mass spectrometry confirmation of amphetamine and metabolites in infant meconium. Matched participants (n = 208) denied methamphetamine use and had a negative meconium screen. At the 7.5 year follow-up, 290 children with complete Child Behavior Checklist (CBCL) data and an early adversity index score were available for analysis (n=146 exposed). Results PME was significantly associated with an increased early adversity index score (P<0.001) and with increased externalizing, rule-breaking behavior, and aggressive behavior (P<0.05). Early adversity was also associated with higher externalizing behavior scores. Early adversity significantly mediated the relationship between PME and behavioral problems. After adjusting the mediation model for sex, prenatal tobacco, alcohol, and marijuana exposures, and study site, the association of PME with early adversity remained significant. Conclusion Though PME is associated with behavioral problems, early adversity may be a strong determinant of behavioral outcome for children exposed to methamphetamine in utero. Early adversity significantly mediated the relationship between PME and behavioral problems.

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A Developmental Psychopathology Perspective on Foster Care Research

Fisher

Leve

Delker

et al. 2016

Developmental Psychopathology

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This chapter provides a developmental psychopathology perspective on foster care research. Empirical studies of foster children have existed for over 100 years, documenting risks faced by this population and instances in which foster children display remarkable resilience. Knowledge emanating from the published studies on foster children, especially where it intersects with research on other populations that have experienced early life adversity, has potential to shed light on how healthy development can be negatively affected, but also how it may be preserved, when adverse rearing conditions exist. Investigations in this area have been conducted across numerous disciplines. Following a brief history of foster care in the United States and elsewhere, we review what is known about nine topics that are germane to the study of foster children from a developmental psychopathology perspective and conclude with a discussion of the translational implications of prior research and directions for future research.

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Examining the relationships between prenatal methamphetamine exposure, early adversity, and child neurobehavioral disinhibition.

Cited by 38 publications

References 78 publications

Risk of Neurobehavioral Disinhibition in Prenatal Methamphetamine–Exposed Young Children With Positive Hair Toxicology Results

Risk of Neurobehavioral Disinhibition in Prenatal Methamphetamine–Exposed Young Children With Positive Hair Toxicology Results

School-Aged Outcomes following Prenatal Methamphetamine Exposure: 7.5-Year Follow-Up from the Infant Development, Environment, and Lifestyle Study

A Developmental Psychopathology Perspective on Foster Care Research

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