2013
DOI: 10.1113/jphysiol.2013.262709
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Exercise counteracts the effects of short‐term overfeeding and reduced physical activity independent of energy imbalance in healthy young men

Abstract: Key points• Physical exercise significantly improves health but to what extent these benefits depend on altered energy balance remains unclear.• In a human experimental model, we investigated whether daily exercise could counteract the effects of short-term overfeeding and under-activity independent of its impact on energy imbalance in healthy young men.• Short-term positive energy balance from overfeeding and under-activity resulted in impaired metabolic outcomes and alterations in the expression of several k… Show more

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Cited by 91 publications
(120 citation statements)
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References 59 publications
(73 reference statements)
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“…SREBP1c and FAS) and protein expression (GLUT4, AMPK, AKT1 and 17 AKT2) within adipose tissue 64 . Significantly, the same short-term overfeeding and 18 reduced physical activity protocol, with inclusion of 45 min of daily treadmill running 19 at 70% maximal oxygen uptake, counteracted most of the detrimental effects at a 20 whole-body and adipose tissue level, despite the provision of additional dietary 21 energy intake to account for the extra energy expended by exercise 64 . 22…”
Section: Interaction Of Overfeeding With Changes In Physical Activitymentioning
confidence: 99%
See 1 more Smart Citation
“…SREBP1c and FAS) and protein expression (GLUT4, AMPK, AKT1 and 17 AKT2) within adipose tissue 64 . Significantly, the same short-term overfeeding and 18 reduced physical activity protocol, with inclusion of 45 min of daily treadmill running 19 at 70% maximal oxygen uptake, counteracted most of the detrimental effects at a 20 whole-body and adipose tissue level, despite the provision of additional dietary 21 energy intake to account for the extra energy expended by exercise 64 . 22…”
Section: Interaction Of Overfeeding With Changes In Physical Activitymentioning
confidence: 99%
“…Wahlin implemented a 13 similar protocol for 7 days, with an overconsumption of 50% excess energy 14 simultaneously restricting the physical activity to below 4,000 steps, and similarly 15 noted a dramatic reduction in insulin sensitivity with modulation of key metabolic 16 genes (e.g. SREBP1c and FAS) and protein expression (GLUT4, AMPK, AKT1 and 17 AKT2) within adipose tissue 64 . Significantly, the same short-term overfeeding and 18 reduced physical activity protocol, with inclusion of 45 min of daily treadmill running 19 at 70% maximal oxygen uptake, counteracted most of the detrimental effects at a 20 whole-body and adipose tissue level, despite the provision of additional dietary 21 energy intake to account for the extra energy expended by exercise 64 .…”
Section: Interaction Of Overfeeding With Changes In Physical Activitymentioning
confidence: 99%
“…Additionally, studies with human subjects and mice suggest that exercise can suppress insulin secretion, and, more importantly, can improve responses to the excess levels of insulin associated with overeating in healthy subjects (56)(57)(58)(59). Thus, if the decrease in GH1 expression reflects the ability of somatotrophs to act as a metabolic sensor (7), specifically to the hyperinsulinemic state, prescribed physical activity is predicted to mitigate against this decrease.…”
Section: Table 2 Primers Used For Qpcrmentioning
confidence: 99%
“…Considering the severity of the growing 460 issue of obesity (87) and the general preoccupation of the public/media with the effects of diet upon disease and mortality risk independent of net energy surplus/deficit or changes in adiposity (88,89) .…”
mentioning
confidence: 99%