Experimental Induction of Bone Tumors by Short-Lived Bone-Seeking Radionuclides

Gössner, W.; Hug, O.; Luz, Arne; Müller, W.

doi:10.1007/978-3-642-80997-2_4

Cited by 16 publications

(14 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osteosarcoma can be readily induced in mice by application of bone-seeking alpha-emitting radioisotopes, and are comparable to human osteosarcomas both histologically and pathobiologically (Gossner et al, 1976;Luz et al, 1991). Murine osteosarcomas are detectable at an early stage, limiting the opportunity for the development of complex genomic alterations, and increasing the likelihood that detected genetic alterations are biologically relevant.…”

Section: Introductionmentioning

confidence: 99%

Two novel tumor suppressor gene loci on chromosome 6q and 15q in human osteosarcoma identified through comparative study of allelic imbalances in mouse and man

et al. 2002

View full text Add to dashboard Cite

We have performed a comparative study of allelic imbalances in human and murine osteosarcomas to identify genetic changes critical for osteosarcomagenesis. Two adjacent but discrete loci on mouse chromosome 9 were found to show high levels of allelic imbalance in radiationinduced osteosarcomas arising in (BALB/c6CBA/CA) F1 hybrid mice. The syntenic human chromosomal regions were investigated in 42 sporadic human osteosarcomas. For the distal locus (OSS1) on mouse chromosome 9 the syntenic human locus was identified on chromosome 6q14 and showed allelic imbalance in 77% of the cases. Comparison between the human and mouse syntenic regions narrowed the locus down to a 4 Mbp fragment flanked by the marker genes ME1 and SCL35A1. For the proximal locus (OSS2) on mouse chromosome 9, a candidate human locus was mapped to chromosome 15q21 in a region showing allelic imbalance in 58% of human osteosarcomas. We have used a combination of synteny and microsatellite mapping to identify two potential osteosarcoma suppressor gene loci. This strategy represents a powerful tool for the identification of new genes important for the formation of human tumors.

show abstract

Section: Introductionmentioning

confidence: 99%

Two novel tumor suppressor gene loci on chromosome 6q and 15q in human osteosarcoma identified through comparative study of allelic imbalances in mouse and man

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Exposure to therapeutic radiation, to radon or radium intake, and to Thoratrast (a bone-seeking isotope) has resulted in the development of osteosarcoma as well as leukemia and lymphoma. [15][16][17][18][19] However, an association between ionizing radiation and Ewing's sarcoma is less clear. 20 In animal experiments, beryllium exposure has produced osteosarcoma.…”

mentioning

confidence: 99%

Epidemiology of osteosarcoma and Ewing's sarcoma in childhood

Buckley

Pendergrass

Buckley

et al. 1998

Cancer

View full text Add to dashboard Cite

“…Induction of osteosarcomas in mice with bone-seeking, short-lived radionuclides such as 224Ra or 22VTh represents a particularly powerful in vivo model to study late effects of incorporated e-emitters. Tumor incidence and tumor latency depend on the radiation dose and the dose rate [21], and the appearance of the tumors as well as the formation of metastases in mice resemble the findings in man [10].…”

Section: Introductionmentioning

confidence: 85%

“…These epidemiological data have been confirmed by internal irradiation in different animal models [10,45]. Induction of osteosarcomas in mice with bone-seeking, short-lived radionuclides such as 224Ra or 22VTh represents a particularly powerful in vivo model to study late effects of incorporated e-emitters.…”

Section: Introductionmentioning

confidence: 90%

Osteosarcomagenic doses of radium (224Ra) and infectious endogenous retroviruses enhance proliferation and osteogenic differentiation of skeletal tissue differentiating in vitro

Schmidt

Heermeier

Linzner

et al. 1994

Radiat Environ Biophys

View full text Add to dashboard Cite

Cartilage tissue from embryonic mice which undergoes osteogenic differentiation during in vitro cultivation was used to study the effect of osteosarcomagenic doses of alpha-irradiation and bone-tumor-inducing retroviruses on proliferation and phenotypic differentiation of skeletal cells in a defined tissue culture model. Irradiated mandibular condyles showed dose-dependent enhancement of cell proliferation at day 7 of the culture and increased osteogenic differentiation at day 14. Maximal effects were found with 7.4 Bq/ml of 224Ra-labeled medium. Doses of 740 and 7400 Bq/ml of 224Ra-labeled medium induced increasing cell death. Retrovirus infection enhanced osteogenic differentiation and extended the viability of irradiated cells. After transplantation none of the treated tissues developed tumors in syngeneic mice.

show abstract

Experimental Induction of Bone Tumors by Short-Lived Bone-Seeking Radionuclides

Cited by 16 publications

References 6 publications

Two novel tumor suppressor gene loci on chromosome 6q and 15q in human osteosarcoma identified through comparative study of allelic imbalances in mouse and man

Two novel tumor suppressor gene loci on chromosome 6q and 15q in human osteosarcoma identified through comparative study of allelic imbalances in mouse and man

Epidemiology of osteosarcoma and Ewing's sarcoma in childhood

Osteosarcomagenic doses of radium (224Ra) and infectious endogenous retroviruses enhance proliferation and osteogenic differentiation of skeletal tissue differentiating in vitro

Contact Info

Product

Resources

About