2020
DOI: 10.3390/brainsci10030166
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Exploratory Analysis of iPSCS-Derived Neuronal Cells as Predictors of Diagnosis and Treatment of Alzheimer Disease

Abstract: Alzheimer’s disease (AD) represents the most common neurodegenerative disorder, with 47 million affected people worldwide. Current treatment strategies are aimed at reducing the symptoms and do slow down the progression of the disease, but inevitably fail in the long-term. Induced pluripotent stem cells (iPSCs)-derived neuronal cells from AD patients have proven to be a reliable model for AD pathogenesis. Here, we have conducted an in silico analysis aimed at identifying pathogenic gene-expression profiles and… Show more

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Cited by 15 publications
(14 citation statements)
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“…Neural progenitor cells (NPCs) can be differentiated from human-induced pluripotent stem cells (hiPSCs) using various methods [1]; they are self-renewing and can differentiate into various types of neurons. Mature neurons induced from hiPSC-NPCs are useful for the physiological, pathological, and pharmacological characterization of human neurons because their accessibility is not limited and because they are free from ethical issues regarding the preparation of neuronal cultures from the human brain [2][3][4][5][6]. With this background, in vitro application of stem cell-derived neurons has been expected, and methods to induce differentiation into various types of neurons have been developed.…”
Section: Introductionmentioning
confidence: 99%
“…Neural progenitor cells (NPCs) can be differentiated from human-induced pluripotent stem cells (hiPSCs) using various methods [1]; they are self-renewing and can differentiate into various types of neurons. Mature neurons induced from hiPSC-NPCs are useful for the physiological, pathological, and pharmacological characterization of human neurons because their accessibility is not limited and because they are free from ethical issues regarding the preparation of neuronal cultures from the human brain [2][3][4][5][6]. With this background, in vitro application of stem cell-derived neurons has been expected, and methods to induce differentiation into various types of neurons have been developed.…”
Section: Introductionmentioning
confidence: 99%
“…Meanwhile, the KEGG database is a database applied to search genomes, promising drug candidates and biological pathways ( 29 ). GO functional term and KEGG signaling pathway enrichment analyses are widely applied to investigate pathogenetic pathways and novel therapeutic approaches for the treatment of several pathological conditions, including autoimmune, neoplastic, psychiatric and neurodegenerative disorders ( 11 , 30 ). DAVID was used to analyze the BPs, CCs and MFs, and the associated signaling pathways of the DEGs ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Human iPSCs have been generated from primary fibroblasts that are isolated from patients with familial AD or from healthy individuals 49 . In iPSCs from sporadic AD, APOE4 can be converted to APOE3 to attenuate multiple AD‐related pathologies, such as Aβ aggregates and hyperphosphorylated tau 50,51 52,53 …”
Section: Overview Of Stem Cell Therapy For Alzheimer's Diseasementioning
confidence: 99%