Exposure, Toxicity, Health Impacts, and Bioavailability of Heavy Metal Mixtures

Wijayawardena, Ayanka; Megharaj, Mallavarapu; Naidu, Ravi

doi:10.1016/bs.agron.2016.03.002

Cited by 50 publications

(23 citation statements)

References 180 publications

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“…Heavy metals enter and accumulate gradually in the human body through diet uptake. Numerous studies have shown that heavy metal pollution is widely spread in animal and plant products, aquatic products, and various processed foods all over the world (Dadar et al, 2016;Liu et al, 2016;Wijayawardena et al, 2016). Heavy metals that enter the human body through chronic exposure are very difficult to metabolize or decompose, so they accumulate in all tissues and organs over the years and exert chronic damage to the body when they reach a certain threshold (Raehsler et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

High-Fat Diet Affects Heavy Metal Accumulation and Toxicity to Mice Liver and Kidney Probably via Gut Microbiota

et al. 2020

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Previous studies proved that heavy metals could increase the risk of disease by acting on the gut microbiota. Meanwhile, gut microbiota played important roles in detoxifying heavy metals. However, the response of gut microbiota to heavy metals and which microbes dominated this detoxification processes are still unclear. This study investigated the difference of high-fat-diet (HFD) and normal-diet (ND) gut microbiota and their response to and detoxification effects on arsenic (As), cadmium (Cd), and lead (Pb) exposure. Results showed that gut microbiota of ND and HFD was significantly different and responded to As, Pb, and Cd exposure differently, too. When exposed to 100 ppm As, Cd, or Pb, HFD-fed mice accumulated more heavy metals in the liver and kidney along with more severe functional damage than NDfed mice, indicated by a more dramatic increase of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and urinary total protein (TPU), urinary uric acid (UUA), and urinary creatinine (Ucrea) content. Among ND gut microbiota, relative abundance of Bacteroides, Lactobacillus, Butyricimonas, and Dorea was significantly increased by arsenic (As) exposure; relative abundance of Faecoccus and Lactobacillus was significantly increased by Cd exposure; relative abundance of Desulfovibrio, Plasmodium, and Roseburia were significantly increased by Pb exposure. However, among HFD gut microbiota, those microbes were not significantly changed. Bivariate association analysis found weak positive correlations between content of fecal excreted heavy metals and richness of total fecal microbiota as well as abundance of some of the heavy metal-enriched microbes. Our study concluded that HFD increased disease risk of heavy metal exposure probably via its gut microbiota which excreted less heavy metal through feces.

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Section: Introductionmentioning

confidence: 99%

High-Fat Diet Affects Heavy Metal Accumulation and Toxicity to Mice Liver and Kidney Probably via Gut Microbiota

et al. 2020

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“…Having a long half-life, a capability to harm the DNA, and consequently a cumulative toxic effect, exposure to Cd(II) as per many regulatory agencies is associated with cancer. Other toxic effects associated with Cd(II) include osteoporosis, height loss in men, kidney damage, elevated blood pressure, and cardiovascular diseases [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Potato Peels as an Adsorbent for Heavy Metals from Aqueous Solutions: Eco-Structuring of aGreenAdsorbent Operating Plackett–Burman Design

El-Azazy

El-Shafie

Issa

et al. 2019

Journal of Chemistry

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Treatment of wastewater is becoming a concern of an increasing prominence. Trace amounts of toxic metalloids and heavy metals (HMs) would contaminate large volumes of water. Being present as traces, removal of these ultratrace contaminants from wastewater is challenging. Adsorption of HMs onto raw (RPP) and burnt (BPP) potato peels (PP) is presented in the current treatise. Both adsorbents (RPP and BPP) proved to be efficient in removing Cd(II), Co(II), Cu(II), Fe(II), La(III), Ni(II), and Pb(II) from aqueous solutions. BPP was a more efficient adsorbent compared to RPP. Ecodesign of a model, green adsorbent was structured executing a multivariate approach, design of experiments (DoE). The purpose of using DoE is to maximize the efficiency of BPP (carbonaceous biomass) as a versatile adsorbent. Plackett–Burman design (PBD) was used as a screening phase. Four factors were considered: pH, contact time (CT), heavy metal concentration (HMC), and the adsorbent dose (AD). The Pareto chart of standardized effects shows that the most influential factor is the HMC. These data were confirmed by analysis of variance (ANOVA). Derringer’s function was operated to find the best factorial blend that maximizes the adsorption process. The percentage (%) removal of Cd(II), for example, was maximized hitting 100%. Adsorbent surface characterization was performed using FTIR, BET, SEM, TGA/dTG, and EDX analyses. Adsorption was found to be physisorption that follows Temkin isotherm with sorption energy 66 kJ/mole. Adsorption kinetics was found to be pseudo-first-order. Adsorption capacity (qm) for BPP was 239.64 mg/g. The diffusion inside the particles was very limited, while the initial rate of the adsorption was extremely high as shown by the Elovich plot.

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“…However, their fine particle size and associated organic matter strongly influence the bioavailability, and transport of pollutants [35,120]. In particular, organo-clay complexes in soil respond to soil warming and the release of bound heavy metals that may become available in soil [121,122].…”

Section: Clay Mineralsmentioning

confidence: 99%

The Fate of Chemical Pollutants with Soil Properties and Processes in the Climate Change Paradigm—A Review

Biswas

et al. 2018

Soil Systems

106

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Heavy metal(loid)s and organic contaminants are two major groups of pollutants in soils. The fate and exposure of such pollutants in soil depends on their chemical properties, speciation, and soil properties. Soil properties and processes that control the toxicological aspects of pollutants include temperature, moisture, organic matter, mineral fractions, and microbial activities. These processes are vulnerable to climate change associated with global warming, including increased incidences of extreme rainfall, extended dry periods, soil erosion, and a rise in sea level. Here we explain evidence that relates to the effects of climate change-driven soil processes on the mobility, transport, and storage of pollutants in soil. The review found that changes in climate could increase human exposure to soil contaminants mainly due to processes involving soil organic carbon (SOC), surface runoff, redox state, and microbial community. However, uncertainties remain in relation to the extent of contaminant toxicity to human health, which is linked to global change drivers.

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Exposure, Toxicity, Health Impacts, and Bioavailability of Heavy Metal Mixtures

Cited by 50 publications

References 180 publications

High-Fat Diet Affects Heavy Metal Accumulation and Toxicity to Mice Liver and Kidney Probably via Gut Microbiota

High-Fat Diet Affects Heavy Metal Accumulation and Toxicity to Mice Liver and Kidney Probably via Gut Microbiota

Potato Peels as an Adsorbent for Heavy Metals from Aqueous Solutions: Eco-Structuring of aGreenAdsorbent Operating Plackett–Burman Design

The Fate of Chemical Pollutants with Soil Properties and Processes in the Climate Change Paradigm—A Review

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