Expression of NMDA, AMPA and GABAA receptor subunit mRNAs in the rat auditory brainstem. I. Influence of early auditory deprivation

Changes in projections to the inferior colliculus following early hearing loss in rats

“…Similar results were obtained for animals tested at either 4 or 12 weeks of age. Thus, the dosage and schedule of treatment with amikacin used here produced deafness in rats with results similar to those previously reported in the literature (Lenoir et al, 1983;Marianowski et al, 2000).…”

“…In the present study, we investigated the susceptibility of auditory brainstem neuronal projections in the rat following early bilateral destruction of the organ of Corti with the aminoglycosidic antibiotic, amikacin (Lenoir et al, 1983;Marianowski et al, 2000). Early treatment with this drug has a powerful ototoxic effect on cochlear hair cells resulting in a profound deafness that is not complicated by the more invasive effects associated with complete removal of the cochlea.…”

“…Early treatment with this drug has a powerful ototoxic effect on cochlear hair cells resulting in a profound deafness that is not complicated by the more invasive effects associated with complete removal of the cochlea. Marianowski et al (2000) reported that amikacin-treated rats had severe lesions of the organ of Corti with complete destruction of the inner and outer hair cells at P16. In the ototoxic deafened animals, ABR assessments showed no brainstem response with sounds as high as 110 dB SPL at P16 and P30 (Marianowski et al, 2000).…”

The Effects of Congenital Deafness on Auditory Nerve Synapses: Type I and Type II Multipolar Cells in the Anteroventral Cochlear Nucleus of Cats

“…Auditory deprivation in the developing animal produces severe abnormalities in the central pathway, whereas older animals are less affected (e.g., Powell and Erulkar 1962;Rubel and Parks 1988;Sie and Rubel 1992;Kelley et al 1997;Sininger et al 1999;Marianowski et al 2000;Zirpel et al 2000). Clinical observations related to the basic research suggest that the best candidates for cochlear implants are very young children or those who developed some linguistic skills before becoming deaf (Waltzman et al 1991;Niparko 1 et al 2000).…”

Pharmacology of the Inferior Colliculus

“…Neurochemical and functional studies document its release, uptake, and action on both AMPA and NMDA receptors (Feldman and Knudsen 1994;Suneja et al 2000;Kelly and Zhang 2002;Ma et al 2002a;Wu et al 2002). Other studies have specified the subunit makeup of the AMPA receptor and the NMDA receptor in the different IC subdivisions (Marianowski et al 2000;Parks 2000) and have suggested that the NMDA receptor plays a role in regulating response plasticity (Feldman et al 1996;Kelly and Zhang 2002;Wu et al 2002). Physiologic studies have begun to assess the relative impact of parallel ascending excitatory inputs onto neurons in the central nucleus of the inferior colliculus (ICC) (Davis 2002;Davis et al 2003).…”