Phyllanthus niruri L. is one of the herbal ingredients that has been widely used to treat various diseases in humans such as intestinal infections, kidney stones, chronic liver disease, diabetes, hepatitis B, asthma, gonorrhea, bronchitis, syphilis and boost the immune system. The ability of P. niruri in overcoming various diseases is based on its phytochemical content and pharmacological properties. Based on these properties, the plant may possibly be used as a drug to treat diseases in fish. So the purpose of writing this article is to review the extent to which P. niruri can be used as an alternative medicine to treat disease and maintain fish health. Secondary metabolites and phyllanthine as specific compounds present in P. niruri have antibacterial effects for types of bacteria that usually attack fish such as Aeromonas hydrophila, Edwardsiella tarda, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa. In addition, it has the effect of being an antioxidant, immunostimulant and can be used for treatment and to increase fish growth. So it can be concluded that P. niruri can be used as an alternative material to maintain health and help fish growth.