Extraction socket grafting using recombinant human bone morphogenetic protein-2-clinical implications and histological observations

Durge, Khushboo; Baliga, Vidya Sudhindra; Sridhar, Shilpa; Dhadse, Prasad; Ragit, Gayatri Chandrakant

doi:10.1186/s13104-021-05476-0

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…The inclusion criteria for the study were as follows. (1) Patients or their family members fully understood the study process and signed the informed consent; (2) patients had nerve root or spinal spondylosis symptoms and needed cervical fusion surgery; and (3) patients were diagnosed with single-segment degenerative cervical spondylotic myelopathy or spinal cord cervical disc herniation [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

A Clinical Study on the Effect of Different Ratios of Recombinant Human Bone Morphogenetic Protein-2 Compound to Autogenous Bone on Cervical Interbody Fusion Based on Smart Healthcare

Zhang

Zhao

Yuan

et al. 2021

Journal of Healthcare Engineering

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With an increasing elderly population worldwide, the incidence of spine degenerative diseases with neck and shoulder pain as the main symptom is rising obviously, which has now become one of the important and difficult problems in sociomedical science. This study was to explore the effects of different ratios of recombinant human bone morphogenetic protein-2 (rhBMP-2) compound to the autogenous bone on cervical interbody fusion. 90 cervical degeneration patients with the need of surgical treatment admitted to our hospital from January 2019 to January 2020 were selected as the research objects and equally divided into group A, group B, and group C according to the order of admission, with 30 cases in each group and the ratios of rhBMP-2 compound to autogenous bone being 2 : 1, 1 : 1, and 1 : 2 respectively, and standard anterior cervical diskectomy and fusion (ACDF) treatment was performed to all patients to compare their surgery-related indexes, the Japanese Orthopaedic Association (JOA) score, the visual analog scale (VAS) score, the effect of cervical interbody fusion, and the postoperative complication rate (CR). Compared with group A and group C, group B achieved the significantly better surgery-related indexes ( P < 0.05 ), significantly higher postoperative JOA scores ( P < 0.05 ), significantly lower postoperative neck and upper limb VAS scores ( P < 0.05 ), significantly better effect of cervical interbody fusion ( P < 0.05 ), and significantly lower postoperative CR ( P < 0.05 ). 1 : 1 is the best ratio of rhBMP-2 compound to the autogenous bone, for it can optimize patients’ perioperative indexes, reduce the postoperative pain, lower the possibility of complications, and improve the effect of cervical interbody fusion, which should be promoted and applied in practice.

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Section: Methodsmentioning

confidence: 99%

A Clinical Study on the Effect of Different Ratios of Recombinant Human Bone Morphogenetic Protein-2 Compound to Autogenous Bone on Cervical Interbody Fusion Based on Smart Healthcare

Zhang

Zhao

Yuan

et al. 2021

Journal of Healthcare Engineering

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“…Even a donor tooth should be healthy and its physical characteristics must match the recipient tooth without compromising occlusion. A tooth with an incompletely formed root with an incomplete apex (an apex greater than 1 mm across) would be much more favorable [ 27 ]. However, autotransplantation of mature teeth with complete root formation can be a predictable treatment and is not necessarily associated with poor prognosis [ 28 ].…”

Section: Reviewmentioning

confidence: 99%

Tooth Autotransplantation as an Alternative Biological Treatment: A Literature Review

Kakde¹,

Rajanikanth²

2022

Cureus

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Tooth autotransplantation is the treatment modality in which a tooth is transferred from one site to another in the same person. This technique has a history of centuries. However, it is not well-known or welldocumented. Essential aspects of the clinical procedure, criteria for performing tooth autotransplantation, advantages, disadvantages, and complications are also discussed in the review. It has been a public health concern considering the prevalence of dental trauma in children, the financial burden of treatment, and the long recovery times associated with dental injuries. There is evidence that tooth autotransplantation is an effective method of restoring missing teeth, particularly for growing children. Even if autotransplantation fails, the soft tissue and bone conditions would likely still be suitable for subsequent implant treatment. Appropriate patient and tooth selection are essential to the technique's success. Other prognostic factors are also discussed. The findings from the available literature suggest that tooth autotransplantation is a viable and cost-effective technique. This paper discusses the literature and protocols the authors implemented for autotransplantation of the tooth.

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“…In the UK, the first healthy human embryo deletion project was approved. On the other hand, the US research team remains traditionalist, restating their position that they do not support such experiments and stating that they are awaiting improvements in defining technical and ethical issues [23][24][25][26][27][28].…”

Section: Safety and Ethical Issuementioning

confidence: 99%

A Review on Gene Therapy

Nilay

Damke

2021

JPRI

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Gene therapy is an emerging concept that gives hope to people with highly fatal conditions. It’s almost three decades since the emergence of the idea of gene therapy. Since then, hundreds of medical trials have been conducted worldwide from which we not only have gained enough knowledge but have experienced the need for it in society. Even though the concept of gene therapy has experienced setbacks, success stories are increasing exponentially, proof of which are recommendations and approvals of gene therapy from various medical associations worldwide. Our knowledge has grown over the years, and during this period, we have come across various safety datahelp help us develop better gene therapy approaches. The chief concept of this procedure is to revamp the vehicles for delivery which typically are nanostructures, plasmids, and viruses. The USA and Europe have been pioneers in gene therapy for a very long period; various reports have come from Asian countries, including India, in recent times. Our knowledge of the concept of gene therapy is increasing day by day. New information and data are being analyzed regularly to help provide gene therapies for different diseases. New research has led to various new drug applications for approval at the FDA. In this review, various points, from the history of gene therapy and its requirement in today’s society to the most recent advances in gene therapy, have been discussed. It also covers the works and advances of gene therapy in India.

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Extraction socket grafting using recombinant human bone morphogenetic protein-2-clinical implications and histological observations

Cited by 4 publications

References 21 publications

A Clinical Study on the Effect of Different Ratios of Recombinant Human Bone Morphogenetic Protein-2 Compound to Autogenous Bone on Cervical Interbody Fusion Based on Smart Healthcare

A Clinical Study on the Effect of Different Ratios of Recombinant Human Bone Morphogenetic Protein-2 Compound to Autogenous Bone on Cervical Interbody Fusion Based on Smart Healthcare

Tooth Autotransplantation as an Alternative Biological Treatment: A Literature Review

A Review on Gene Therapy

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