Fabrication and characterization of extruded and spheronized beads containing carbopol® 974P, NF resin

Neau, Steven H.; Chow, Michelle Y.; Durrani, Manzer J.

doi:10.1016/0378-5173(95)04293-8

Cited by 44 publications

(14 citation statements)

References 5 publications

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“…These results are in agreement with a report describing the effect of molarity on dissolution rates of chlorpheniramine maleate,another cationic drug,from beads manufactured by extrusion-spheronization (11). The high molarity of the dissolution medium is thought to weaken the rigid/cross-linked structure of carbomer gels by interfering with the repulsive forces that exist between charged polymer molecules in the system.…”

Section: Effect Of Molaritysupporting

confidence: 82%

The Effects of Buffer Molarity, Agitation Rate, and Mesh Size on Verapamil Release from Modified-Release Mini-Tablets Using USP Apparatus 3

Khamanga¹,

Walker²

2007

Dissolution Technol.

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Section: Effect Of Molaritysupporting

confidence: 82%

The Effects of Buffer Molarity, Agitation Rate, and Mesh Size on Verapamil Release from Modified-Release Mini-Tablets Using USP Apparatus 3

Khamanga¹,

Walker²

2007

Dissolution Technol.

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“…The increase in NVP release with increase in buffer molarity in the earlier stages of the test may be attributed to the weakening of the gel layer surrounding the tablets, thereby increasing the surface area for NVP release (25). However, after 8 h of testing, the molarity of the buffer did not appear to affect the rate of NVP release.…”

Section: Effect Of Buffer Molarity On Dissolution Rate Of Nvpmentioning

confidence: 79%

Development and Assessment of a USP Apparatus 3 Dissolution Test Method for Sustained-Release Nevirapine Matrix Tablets

Mwila¹,

Khamanga²,

Walker³

2016

Dissolution Technol.

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Dissolution testing is a quality control tool used to assess batch-to-batch performance of dosage forms, thereby providing continued assurance of product quality. Analytical methods for the assessment of pharmaceutical product quality must be validated according to regulatory guidelines to ensure that tests are reliable and valid. Agitation rate, mesh pore size, surfactant concentration, and dissolution medium molarity are experimental parameters that may affect nevirapine (NVP) release and were investigated and optimized to ensure that consistent, reliable, and valid results using Apparatus 3 were produced. Agitation rate was investigated to establish an equivalent response to that observed for NVP release using Apparatus 2 at 50 rpm. A reciprocation rate of 5-10 dpm produced dissolution profiles that were similar to those observed using Apparatus 2. An increase in the molarity of the dissolution medium slightly increased the release rate of NVP, and a 50 mM buffer maintained at pH values mimicking gastrointestinal tract (GIT) conditions was selected for all experiments. With the addition of 2% sodium lauryl sulfate (SLS) to the dissolution medium, >80% NVP was released from the tablets over the test period. The NVP release rate increased with an increase in the mesh pore size; however, the extent of release was not affected by this parameter. Dissolution test samples were analyzed using HPLC, and dissolution methods were validated for NVP stability in the dissolution medium, specificity, linearity and range, repeatability, intermediate precision, and accuracy as defined by ICH. The dissolution method used for testing NVP tablets can be regarded as an appropriate tool for the evaluation of sustained-release (SR) NVP formulations and the impact of formulation composition and product quality attributes on drug release.

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“…3). This could be due to cationic propranolol relating well to the carboxylate groups of xanthan gum even as carboxylates from crosslinked polyacrylic acid can sustain chlorpheniramine maleate release (58). This ionic interaction is not available with nonionic guar gum and HPMC.…”

Section: Resultsmentioning

confidence: 99%

Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride

2010

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Abstract. The objectives were to characterize propranolol hydrochloride-loaded matrix tablets using guar gum, xanthan gum, and hydroxypropylmethylcellulose (HPMC) as rate-retarding polymers. Tablets were prepared by wet granulation using these polymers alone and in combination, and physical properties of the granules and tablets were studied. Drug release was evaluated in simulated gastric and intestinal media. Rugged tablets with appropriate physical properties were obtained. Empirical and semi-empirical models were fit to release data to elucidate release mechanisms. Guar gum alone was unable to control drug release until a 1:3 drug/gum ratio, where the release pattern matched a Higuchi profile. Matrix tablets incorporating HPMC provided near zero-order release over 12 h and erosion was a contributing mechanism. Combinations of HPMC with guar or xanthan gum resulted in a Higuchi release profile, revealing the dominance of the high viscosity gel formed by HPMC. As the single rate-retarding polymer, xanthan gum retarded release over 24 h and the Higuchi model best fit the data. When mixed with guar gum, at 10% or 20% xanthan levels, xanthan gum was unable to control release. However, tablets containing 30% guar gum and 30% xanthan gum behaved as if xanthan gum was the sole rate-retarding gum and drug was released by Fickian diffusion. Release profiles from certain tablets match 12-h literature profiles and the 24-h profile of Inderal ® LA. The results confirm that guar gum, xanthan gum, and HPMC can be used for the successful preparation of sustained release oral propranolol hydrochoride tablets.

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Fabrication and characterization of extruded and spheronized beads containing carbopol® 974P, NF resin

Cited by 44 publications

References 5 publications

The Effects of Buffer Molarity, Agitation Rate, and Mesh Size on Verapamil Release from Modified-Release Mini-Tablets Using USP Apparatus 3

The Effects of Buffer Molarity, Agitation Rate, and Mesh Size on Verapamil Release from Modified-Release Mini-Tablets Using USP Apparatus 3

Development and Assessment of a USP Apparatus 3 Dissolution Test Method for Sustained-Release Nevirapine Matrix Tablets

Guar Gum, Xanthan Gum, and HPMC Can Define Release Mechanisms and Sustain Release of Propranolol Hydrochloride

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