Fabrication of a silver octahedral nanoparticle-containing polycaprolactone nanocomposite for antibacterial bone scaffolds

Gao, Yu; Hassanbhai, Ammar Mansoor; Lim, Jing; Wang, Lianhui; Xu, Chen

doi:10.1039/c6ra26063b

Cited by 16 publications

(11 citation statements)

References 31 publications

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“…The fabricated 3D PCL/AgNPs scaffold showed very promising antibacterial properties which could be present both on implantation and over a longer period whilst the scaffold degrades. This finding is in line with Gao et al, where the addition of 1 wt.% AgNPs managed to reduce bacteria survival to 32.2% over a four h incubation period [ 70 ]. When incorporated in a scaffold, AgNPs may come into direct contact with the bacterial cellular membrane, generating Ag + ions in the process to annihilate the bacteria without the need for the AgNPs to penetrate the bacterial cell [ 19 ].…”

Section: Resultssupporting

confidence: 90%

Green Synthesis of Silver Nanoparticles Using Extract of Cilembu Sweet Potatoes (Ipomoea batatas L var. Rancing) as Potential Filler for 3D Printed Electroactive and Anti-Infection Scaffolds

et al. 2021

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Electroactive biomaterials are fascinating for tissue engineering applications because of their ability to deliver electrical stimulation directly to cells, tissue, and organs. One particularly attractive conductive filler for electroactive biomaterials is silver nanoparticles (AgNPs) because of their high conductivity, antibacterial activity, and ability to promote bone healing. However, production of AgNPs involves a toxic reducing agent which would inhibit biological scaffold performance. This work explores facile and green synthesis of AgNPs using extract of Cilembu sweet potato and studies the effect of baking and precursor concentrations (1, 10 and 100 mM) on AgNPs’ properties. Transmission electron microscope (TEM) results revealed that the smallest particle size of AgNPs (9.95 ± 3.69 nm) with nodular morphology was obtained by utilization of baked extract and ten mM AgNO3. Polycaprolactone (PCL)/AgNPs scaffolds exhibited several enhancements compared to PCL scaffolds. Compressive strength was six times greater (3.88 ± 0.42 MPa), more hydrophilic (contact angle of 76.8 ± 1.7°), conductive (2.3 ± 0.5 × 10−3 S/cm) and exhibited anti-bacterial properties against Staphylococcus aureus ATCC3658 (99.5% reduction of surviving bacteria). Despite the promising results, further investigation on biological assessment is required to obtain comprehensive study of this scaffold. This green synthesis approach together with the use of 3D printing opens a new route to manufacture AgNPs-based electroactive with improved anti-bacterial properties without utilization of any toxic organic solvents.

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Section: Resultssupporting

confidence: 90%

Green Synthesis of Silver Nanoparticles Using Extract of Cilembu Sweet Potatoes (Ipomoea batatas L var. Rancing) as Potential Filler for 3D Printed Electroactive and Anti-Infection Scaffolds

et al. 2021

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“…Interestingly, the PCL core of polyurethane (PU) micelles degraded and released the decorated silver nanoparticles in the presence of lipase, which resulted in excellent antibacterial activity of the nanocomposites with minimum toxicity against mammalian cells. In similar study, the growth of octahedral‐shaped nanosilver particle within PCL matrix was reported for antibacterial bone scaffolds . The nanocomposite as scaffold exhibited localized antibacterial activity without any adverse effect on viability of human fetal mesenchymal stem cells.…”

Section: Designing Of Functional Nanosilver Within Nanogelsupporting

confidence: 54%

“…The reduction of silver ions into nanosilver has led to the development of several commercial products . The reduction step in nanotechnology is very important.…”

Section: Future Perspectivesmentioning

confidence: 99%

Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare Systems

Anjum¹,

Gupta²

2018

Global Challenges

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Functional designing of nanogels has become an attractive domain of biomedical engineering to develop bioactive materials with innovative features for the human healthcare system. Nanosilver has attracted enormous attention due to its wide antimicrobial spectrum and ability to kill almost all types of bacteria in its vicinity. However, the most crucial challenge for bioscientists is the lack of binding ability of nanosilver with the material surfaces that allow nanosilver to leach out to the surrounding tissue and exert toxicity while the biomaterial is in contact with the living system. Designing nanosilver within a nanogel confinement offers enormous possibilities to develop functional bioactive nanoparticles that may be bonded to any biomaterial surface via the nanogel functionality. This approach requires the proper combination of material science with nanotechnology and biotechnology to innovate interesting domain of functional nanogels with unique features. This work aims at providing a critical review on the current progress, approaches, and vision in designing nanosilver‐entrapped nanogel particles with diverse functionality, and their bioactivity against microorganisms for human healthcare devices.

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“…When the studies on the production of scaffolds by various methods using Ag nanoparticles in their structures, which were designed for use in bone tissue cells, were investigated, it was observed that cytotoxicity was related to silver concentration . For example, while Marsich et al and Bakare et al found the 0.05% silver ratio for their bone tissue structure composites, Hasan et al, Alt et al and Gao et al stated that 1% and 2.5% Ag content suitable for bone tissue applications. Based on these data, the nanocomposite structure obtained in this study has the potential to be used in bone tissue applications.…”

Section: Resultsmentioning

confidence: 99%

Optimization of the electrospinning process variables for gelatin/silver nanoparticles/bioactive glass nanocomposites for bone tissue engineering

2020

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The current research focuses on the findings of an investigation on optimizing of an electrospun antibacterial gelatin nanocomposite membrane for bone tissue engineering applications. For this reason, soluble starch coated silver nanoparticles (Ag‐NPs) and bioactive glass particles (BG) were incorporated in to gelatin (Gt) to fabricate Gt/Ag‐NPs/BG nanocomposite membranes. Employing Box‐Behnken design, second‐order models have been successfully obtained to evaluate the statistical significance of individual and interaction effects of applied voltage, tip‐to‐collector distance (TCD), and flow rate on fiber diameter. There was a reasonable agreement between the regression R2 value (0.9542), R2 predicted value (0.8768), and the R2 adjusted value (0.9286) across the entire factor space with identical observations for the experimental and model values. Under optimum conditions (applied voltage of 26 kV, TCD of 180 mm, and flow rate of 0.5 mL/h), the nanocomposite membrane with similar fiber size of bone tissue extracellular matrix can be fabricated with the predicted value of 557 nm obtained by the proposed model. The optimized nanofiber membrane was fabricated under these conditions and average fiber diameter of this membrane was found as 472 ± 94 nm. The characterization studies of this nanofiber suggest that obtained nanocomposite is a potential candidate for bone tissue engineering applications.

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Fabrication of a silver octahedral nanoparticle-containing polycaprolactone nanocomposite for antibacterial bone scaffolds

Abstract: Ag octahedral nanoparticle-containing PCL nanocomposite scaffolds exhibit successful osteogenic differentiation of stem cells and localized antibacterial effects.

Cited by 16 publications

References 31 publications

Green Synthesis of Silver Nanoparticles Using Extract of Cilembu Sweet Potatoes (Ipomoea batatas L var. Rancing) as Potential Filler for 3D Printed Electroactive and Anti-Infection Scaffolds

Green Synthesis of Silver Nanoparticles Using Extract of Cilembu Sweet Potatoes (Ipomoea batatas L var. Rancing) as Potential Filler for 3D Printed Electroactive and Anti-Infection Scaffolds

Bioengineering of Functional Nanosilver Nanogels for Smart Healthcare Systems

Optimization of the electrospinning process variables for gelatin/silver nanoparticles/bioactive glass nanocomposites for bone tissue engineering

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