Fabrication of palladium nanoparticles anchored polypyrrole functionalized reduced graphene oxide nanocomposite for antibiofilm associated orthopedic tissue engineering

Murugesan, Balaji; Nithya, P.; Arumugam, Mayakrishnan; Sonamuthu, Jegatheeswaran; Selvam, S.; Cai, Yurong; Yao, Juming; Muthusubramanian, Shanmugam

doi:10.1016/j.apsusc.2020.145403

Cited by 67 publications

(27 citation statements)

References 76 publications

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“…Biofilms play a very critical role in successfully producing virulence factors that are controlled by a feed-forward control loop of quorum sensing signals (production of acyl-homoserine lactones) and thus a drug-resistant infection establishes 64 . To date, no antibiofilm study of marine algae-mediated Pd-NPs has been reported, however, a nanocomposite of Pd-graphene oxide showed a reduction in biofilm formation of Bacillus subtilis , E. coli , P. aeruginosa , Klebsiella pneumoniae by microdilution method 65 . Besides, extra polymeric substance (EPS), biofilms also contain lipids, proteins, and DNA that resist higher concentrations of antibiotics and compromise the host immune system.…”

Section: Resultsmentioning

confidence: 98%

“…64 . To date, no antibiofilm study of marine algae-mediated Pd-NPs has been reported, however, a nanocomposite of Pd-graphene oxide showed a reduction in biofilm formation of Bacillus subtilis, E. coli, P. aeruginosa, Klebsiella pneumoniae by microdilution method 65 . Besides, extra polymeric substance (EPS), biofilms also contain lipids, proteins, and DNA that resist higher concentrations of antibiotics and compromise the host immune system.…”

Section: Biofilm Inhibition Of Isolates By Pb-capped Pd-nps Biofilm mentioning

confidence: 98%

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Padina boryana mediated green synthesis of crystalline palladium nanoparticles as potential nanodrug against multidrug resistant bacteria and cancer cells

Sonbol

Ameen

Alyahya

et al. 2021

Sci Rep

146

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Green synthesized nanoparticles (NPs) have emerged as a new and promising alternative to overcome the drug resistance problem. Peculiar nano-specific features of palladium NPs (Pd-NPs) offer invaluable possibilities for clinical treatment. Due to the development of multi-drug resistance (MDR) in pathogenic bacteria and the prevalence of cancers, use of algae-mediated Pd-NPs could be a prospective substitute. Therefore, Pd-NPs were synthesized by a one-step, cost-effective, and environmentally friendly green method using the extract from a brown alga, Padina boryana (PB-extract), and evaluated for their antibacterial, antibiofilm, and anticancer activities. Pd-NPs were physicochemically characterized for size, shape, morphology, surface area, charge, atomic composition, crystal structure, and capping of Pd-NPs by PB-extract biomolecules by various techniques. The data revealed crystalline Pd-NPs with an average diameter of 8.7 nm, crystal size/structure of 11.16 nm/face-centered cubic, lattice d-spacing of 0.226 nm, 28.31% as atomic percentage, surface area of 16.1 m2/g, hydrodynamic size of 48 nm, and zeta-potential of − 28.7 ± 1.6 mV. Fourier-transform infrared spectroscopy (FT-IR) analysis revealed the role of PB-extract in capping of Pd-NPs by various functional groups such as –OH, C=C, C–O, and C–N from phenols, aliphatic hydrocarbons, aromatic rings, and aliphatic amine. Out of 31, 23 compounds were found involved in biosynthesis by Gas chromatography–mass spectrometry (GC–MS) analysis. Isolated strains were identified as MDR Staphylococcus aureus, Escherichia fergusonii, Acinetobacter pittii, Pseudomonas aeruginosa, Aeromonas enteropelogenes, and Proteus mirabilis and Pd-NPs exhibited strong antibacterial/antibiofilm activities against them with minimum inhibitory concentration (MIC) in the range of 62.5–125 μg/mL. Moreover, cell viability assays showed concentration-dependent anti-proliferation of breast cancer MCF-7 cells. Pd-NPs also enhanced mRNA expression of apoptotic marker genes in the order: p53 (5.5-folds) > bax (3.5-folds) > caspase-3 (3-folds) > caspase-9 (2-folds) at 125 μg/mL. This study suggested the possible role of PB-extract capped Pd-NPs for successful clinical management of MDR pathogens and breast cancer cells.

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Section: Resultsmentioning

confidence: 98%

Section: Biofilm Inhibition Of Isolates By Pb-capped Pd-nps Biofilm mentioning

confidence: 98%

Padina boryana mediated green synthesis of crystalline palladium nanoparticles as potential nanodrug against multidrug resistant bacteria and cancer cells

Sonbol

Ameen

Alyahya

et al. 2021

Sci Rep

146

View full text Add to dashboard Cite

show abstract

“…The value of zeta potential shows the potential stability of the Pd nanoparticle solution, and the nanoparticles' surfaces are negatively charged (−9.2 mV) and evenly dispersed throughout the medium. According to published research, particles in a stable suspension have zeta potential ranging between +30 and −30 mV [48,49].…”

Section: Characterization Of Pd-npsmentioning

confidence: 99%

“…The first mechanism is that nanoscale palladium particles stick to the cell wall and hinder cell/bacterial development and multiplication, causing the cell wall to be disrupted and unable to protect the cell's interior [50]. The second mechanism is that Pd-NPs penetrate the bacterial cell and alter the normal development of nucleic acids, which leads to cell death or at the very least DNA damage [49]. The third mechanism is that the bacterial cell wall is irreversibly disrupted by the engagement of Pd + ions with sulfur-containing proteins in the cell wall.…”

Section: Antimicrobial and Anticancer Mechanismsmentioning

confidence: 99%

Characterization, Antimicrobial and Anticancer Properties of Palladium Nanoparticles Biosynthesized Optimally Using Saudi Propolis

et al. 2021

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Due to their unique physicochemical characteristics, palladium nanoparticles (Pd-NPs) have shown tremendous promise in biological applications. The biosynthesis of Pd-NPs employing Saudi propolis has been designed to be environmental, fast, controlled, and cost-effective. The formation and stability of biosynthesized Pd-NPs by Saudi propolis extract were proved by ultraviolet–visible spectrophotometry (UV-Vis), Fourier-transform infrared spectroscopy (FT-IR), and Zeta potential analysis. Transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray diffraction (XRD) findings show that the average particle size of Pd-NPs is between 3.14 and 4.62 nm, which is in quantum scale. The Saudi propolis enhanced the antimicrobial activity against B. subtilis, S. aureus, E. coli, K. pneumoniae, and C. albicans. Pd-NPs show effective anticancer activity against ductal carcinoma (MCF-7) with IC50 of 104.79 µg/mL.

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“…Nanoscale materials, especially metal oxide nanoparticles are considered as a distinctive group of materials with unique physicochemical properties and possess broad applications in various scientific areas such as sensing technology [1,2], cell adhesion and tissue engineering [3], industrial packaging [4,5] catalysis [6,7] and biomedical investigations [8,9]. Zinc oxide nanoparticles (ZnONPs) are among all metal oxide nanoparticles, which have received extensive attention for their advanced biocompatible feature and high strength under utmost circumstances [10,11].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Eco-Friendly Synthesis of ZnO Nanoparticles in Biomedical Applications

Al-Mohaimeed¹,

Al-onazi²,

El‐Tohamy³

2021

Preprint

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This study describes an eco-friendly synthesis of ZnO nanoparticles using aqueous oat extract. The advanced electrochemical and optical features of green synthesized ZnONPs displayed excellent antibacterial activity, and exhibited an important role in pharmaceutical determinations. The formation of nanoscale ZnO was confirmed using various spectroscopic and microscopic investigations. The formed nanoparticles were found to be around 100 nm. The as-prepared ZnONPs were monitored for their antibacterial potential against different bacterial strains. The inhibition zones for ZnONPs were found as E. coli (16 mm), P. aeruginosa (17 mm), S. aureus (12 mm) and B. subtilis (11 mm) using 30 µg mL-1 sample concentration. Also, ZnONPs exhibited significant antioxidant effects 58 to 67 % with an average IC50 value of 0.88 ± 0.03 scavenging activity and 53 to 71 % (IC50 value 0.73 ± 0.05) against the DPPH and ABTS scavenging free radicals, respectively. The photocatalytic potential of ZnONPs for Rhodamine B dye degradation dye under UV irradiation was performed. The photodegradation process was carried out as a function of time-dependent and the complete degradation (nearly 98 %) with color removal after 120 min. Conclusively, the synthesized ZnONPs using oat biomass might provide a great promise in the future for biomedical applications.

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Fabrication of palladium nanoparticles anchored polypyrrole functionalized reduced graphene oxide nanocomposite for antibiofilm associated orthopedic tissue engineering

Cited by 67 publications

References 76 publications

Padina boryana mediated green synthesis of crystalline palladium nanoparticles as potential nanodrug against multidrug resistant bacteria and cancer cells

Padina boryana mediated green synthesis of crystalline palladium nanoparticles as potential nanodrug against multidrug resistant bacteria and cancer cells

Characterization, Antimicrobial and Anticancer Properties of Palladium Nanoparticles Biosynthesized Optimally Using Saudi Propolis

Multifunctional Eco-Friendly Synthesis of ZnO Nanoparticles in Biomedical Applications

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