2017
DOI: 10.1021/acs.biomac.7b00089
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Facile Access to Multisensitive and Self-Healing Hydrogels with Reversible and Dynamic Boronic Ester and Disulfide Linkages

Abstract: Multifunctional and multiresponsive hydrogels have presented a promising platform to design and fabricate smart devices for application in a wide variety of fields. However, their preparations often involve multistep preparation of multiresponsive polymer precursors, tedious reactions to introduce functional groups or sophisticated molecular designs. In this work, a multifunctional boronic acid-based cross-linker bis(phenylboronic acid carbamoyl) cystamine (BPBAC) was readily prepared from inexpensive commerci… Show more

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Cited by 211 publications
(144 citation statements)
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“…Self‐healing hydrogels drew great attentions in past decade because of their self‐healing property similar to the living creatures and wide application in bioscience and biotechnologies . As a result, large amount of self‐healing hydrogels were reported based on both intermolecular force and reversible dynamic bond . The self‐healing hydrogel can be based on a series of dynamic covalent bonds and each has its own advantages.…”
Section: Introductionmentioning
confidence: 99%
“…Self‐healing hydrogels drew great attentions in past decade because of their self‐healing property similar to the living creatures and wide application in bioscience and biotechnologies . As a result, large amount of self‐healing hydrogels were reported based on both intermolecular force and reversible dynamic bond . The self‐healing hydrogel can be based on a series of dynamic covalent bonds and each has its own advantages.…”
Section: Introductionmentioning
confidence: 99%
“…These stimuli‐responsive polymers and hydrogels have wide applications in drug delivery, emulsification, identification, detection, sensing, coatings, and so forth . The response of such smart polymers (block, graft, star, cyclic, and cross‐linked/hyperbranched polymers) and hydrogels to stimuli such as pH, temperature, redox, light (ultraviolet or visible), and magnetic field has been widely and extensively studied in last decades . Stimuli‐responsive amphiphilic polymers tend to self‐assemble in different morphologies in the aqueous solution and can noncovalently encapsulate hydrophobic dyes and drugs in their self‐assembled structures .…”
Section: Introductionmentioning
confidence: 99%
“…Stimuli‐responsive functional groups on these polymers can be introduced by modification reactions such as EDC, DCC, and other click/coupling reactions . On the other hand, aliphatic synthetic polymers with stimuli‐responsive groups and the hydrogels therefrom have been widely explored …”
Section: Introductionmentioning
confidence: 99%
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“…The cross‐linking of nanoparticulate systems by tumor cell microenvironment responsive bonds, such as disulfide, acetal, or hydrazone bonds, has been proven to be an effective route to improve the stability and enable intracellular‐triggered drug release . Especially, the redox‐responsive disulfide bonds had demonstrated great potential for drug delivery in cancer treatment, as the disulfide bonds can remain stable in a predominantly oxidizing extracellular space, while being cleaved by the tumoral intracellular glutathione (GSH, 2–10 × 10 −3 m ) . However, the function of intracellular‐triggered drug release has barely been integrated into the liposomal systems.…”
Section: Introductionmentioning
confidence: 99%