Facile multifunctional IOL surface modification via poly(PEGMA-co-GMA) grafting for posterior capsular opacification inhibition

Abstract

Drug eluting and hydrophilic intraocular lens surface coating was facilely fabricated via poly(PEGMA-co-GMA) grafting. Such a multifunctional coating reduced posterior capsular opacification incidence after implantation effectively.

Design of foldable, responsively drug-eluting polyacrylic intraocular lens bulk materials for prevention of postoperative complications

“…5 Â 10 3 cells in 200 mL of complete medium were seeded into each well and cultured for 24 h. Then 20 mL of the extract was added and incubated in an incubator for 24 and 48 h. At each time interval, cell viability was measured using the CCK-8 method. 42 In addition, before inoculating cells, the materials were loaded into 96-well plates and sterilized under ultraviolet light for 30 min. Then the cells were seeded into the wells according to the above method and cultured for 24 and 48 h. Hoechst 33342 staining results were observed at each time interval using an inverted phase contrast microscope (Leica, DMi8).…”

Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery

“…In addition to the pharmacological effects of DOX, this modification increased sensitivity to metalloproteinases (MMPs), a protein found to be up-regulated during LEC proliferation. The hydrophilicity of PEGMA itself was also applied by Xia et al (2021) to work with DOX to further inhibit PCO. Zhu et al (2022) used exosomes extracted from LECs to carry DOX.…”

A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis

“…Previous studies focused on IOLs modification to prepare drug-loaded IOLs. Surface coating [ [11] , [12] , [13] , [14] , [15] , [16] , [17] ], chemical grafting [ [18] , [19] , [20] ], electrostatic interaction [ 21 ], and layer-by-layer self-assembly [ 22 , 23 ], which were all classified as surface modification techniques, have been studied. The ideas of creating extra drug-loading spaces on haptics were also reported [ 24 , 25 ].…”