Facile synthesis of mesoporous alumina using hexadecyltrimethylammonium bromide (HTAB) as template: simplified sol‐gel approach

Abstract

Herein the authors present the synthesis of surface functionalised mesoporous alumina (MeAl) for textural characterisation by a simplified sol-gel method obtained by using hexadecyltrimethylammonium bromide as a template. Etoricoxib (ETOX) was used as a model drug for the study. Alumina supported mesoporous material containing drug was characterised using instrumental technique namely Brunauer-Emmett-Teller surface area, Fourier transform-infrared, differential scanning calorimetry, transmission electron microscopy, X-ray diffraction, and field emission scanning electron microscopy. Diffusion study using a dialysis bag method used to check the release pattern of ETOX-loaded-MeAl. Results of characterisation study revealed the successful surface functionalisation of the drug on nanocomposite. The IC 50 value obtained from cell viability study demonstrated the non-toxic behaviour of synthesised drug-loaded mesoporous alumina up to the tested concentration range. The present work has demonstrated that synthesised MeAl showed excellent stability with an expanded surface area suitable for carrier material for drug delivery system.

Exploring the Multifunctionality of Mechanochemically Synthesized γ-Alumina with Incorporated Selected Metal Oxide Species

“…As compared to silica-based materials, porous alumina is more popular in catalysis, mainly in the petrochemical industries [7] because of its unique surface properties (e.g., acidic, and basic sites) and tailorable porosity [7,8]. There are various methods for the synthesis of porous alumina such as sol-gel [9,10], reverse micelle [11], solvothermal [12], microwave-assisted [13], aerosol [14], polymer templating [15], etc., and many of these methods use both cationic and anionic surfactants [16]. The synthesis of porous metal oxide nanomaterials is gaining attention due to their wide applications, and easy merging with silica, alumina, and carbon frameworks.…”

Observation of alumina nanoparticles generated from aqueous solutions of a “flat” aluminum-13 cluster

“…This makes comparison to current techniques difficult, however sources show that PDIs around 0.2 represent a monodisperse solution. 27 Previous reports have highlighted the importance of corroborative techniques to assess particle size and purity. 28 To this end, additional analysis methods were leveraged to analyze the presence and nature of the nanoscale species.…”

“…This makes comparison to current techniques difficult, however sources show that PDIs around 0.2 represent a monodisperse solution. 27…”