Factors affecting hydrolysis of polyvinyl acetate to polyvinyl alcohol

Aruldass, Sherrine; Mathivanan, V.; Mohamed, Abdul Rahman; Tye, Ching Thian

doi:10.1016/j.jece.2019.103238

Cited by 53 publications

(24 citation statements)

References 8 publications

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“…Moreover, the microneedle is an efficient platform to make easy handling and reduce the fear of invasiveness . Among these advantages, solubility is a significant factor in biodegradable MN patches that determines the properties of PVA because it is highly dependent on saponification. , Substances with a degree of saponification of 99.0 mol % or more have a strong intermolecular hydrogen bond and a high melting point due to increased conversion to alcohol in acetic acid, and they are difficult to dissolve in water. Therefore, we have tried to improve the solubility by adding a substance with a low degree of saponification .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a PVA-Based Hydrogel Microneedle Patch

Hwang

2022

ACS Omega

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The degree of saponification, which is a dissolution characteristic of poly(vinyl alcohol) (PVA), is used to blend PVA to prepare a hydrogel microneedle (MN) patch. The MN patch was manufactured with an adjustable disassembly time using a molding process, and it was confirmed to have morphological stability and excellent needle formation. The permeability of the gelatin sheet, which is analogous to the skin elasticity coefficient of a real human, was confirmed. The penetration ratio had a very high value of 100% and sufficient physical properties to penetrate the skin. In the disassembly experiment, the MN patch was produced with ratios of lower:higher saponification of 6:4 (PVA6), 7:3 (PVA7), 8:2 (PVA8), 9:1 (PVA9), and 10:0 (PVA10). Degradation did not occur for PVA6 and PVA7 but occurred for PVA8, PVA9, and PVA10. A cytotoxicity test to investigate its suitability for use in the human body confirmed the cell viability of 80% or more and nontoxic properties. Therefore, sufficient cell viability was confirmed when compared to the existing products.

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Section: Introductionmentioning

confidence: 99%

Fabrication of a PVA-Based Hydrogel Microneedle Patch

Hwang

2022

ACS Omega

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“…Barrera et al [4] showed that the degree of hydrolysis of the PVA molecular chains generated significant differences in the glass transition temperature (Tg), the melting temperature (Tm) and the thermal degradation mechanisms of the PVA films. Aruldass et al [5] reported an increment in the crystallinity and water solubility of the PVA films when increasing the hydrolysis degree of PVA. The greater PVA crystallinity promoted, in turn, the development of smoother film surfaces.…”

Section: Introductionmentioning

confidence: 99%

Effect of carvacrol in the properties of films based on poly (vinyl alcohol) with different molecular characteristics

Andrade

González‐Martínez

Chiralt

2020

Polymer Degradation and Stability

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“…Meanwhile, PVA also tends to be oxidized by iodine radicals at high temperature. 36,37 Although the hydrolysis of PVAc carried out with a acid catalyst in a pure water system is inhibited, 38 the PVA dispersant was regarded as one of the reasons for the side reactions, in which the high amount of hydroxyl groups (-OH) of PVA dispersant relative to iodine groups (-I) existed. A portion of PVA is degraded into ketone and aldehyde specimens by reacting with free iodine radicals (Scheme 1(b)).…”

Section: Papermentioning

confidence: 99%