Factors associated with sleep quality during chemotherapy: An integrative review

Souza, Regina Cláudia da Silva; Santos, Maiara Rodrigues dos; Valóta, Izabel Alves das Chagas; Sousa, Cristina Silva; Calache, Ana Lúcia Siqueira Costa

doi:10.1002/nop2.516

Cited by 26 publications

(27 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The efficacy of treatments might be affected by the precipitating or perpetuating factors of chemotherapy-associated insomnia [ 7 , 8 ]. Acupuncture has been reported to generate an 8.3-point reduction in ISI score among cancer survivors who have completed active treatments [ 33 ], and about 6-point reduction among breast cancer patients undergo or post-chemotherapy in our present and previous trial [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Acupuncture for chemotherapy-associated insomnia in breast cancer patients: an assessor-participant blinded, randomized, sham-controlled trial

Zhang

Qin

et al. 2023

Breast Cancer Res

View full text Add to dashboard Cite

Background Insomnia is a highly prevalent symptom occurred during and post-chemotherapy. Acupuncture may have beneficial effects in the management of chemotherapy-associated insomnia. This study was conducted to determine the efficacy and safety of acupuncture in improving chemotherapy-associated insomnia in breast cancer patients. Methods This assessor-participant blinded, randomized, sham-controlled trial was conducted from November 2019 to January 2022 (follow-up completed July 2022). Participants were referred by oncologists from two Hong Kong hospitals. Assessments and interventions were conducted at the outpatient clinic of School of Chinese Medicine, the University of Hong Kong. The 138 breast cancer patients with chemotherapy-associated insomnia were randomly assigned to receive either 15 sessions of active acupuncture regimen by combining needling into body acupoints and acupressure on auricular acupoints or sham acupuncture control (69 each) for 18 weeks, followed by 24 weeks of follow-up. The primary outcome was measured using Insomnia Severity Index (ISI). Secondary outcomes included the Pittsburgh Sleep Quality Index, Actiwatch and sleep diary for sleep parameters, depression and anxiety, fatigue and pain, and quality of life. Results There were 87.7% (121/138) participants who completed the primary endpoint (week-6). The active acupuncture regimen was not superior to the sham control in reducing ISI score from baseline to 6 weeks (mean difference: − 0.4, 95% CI − 1.8–1.1; P = 0.609), but produced short-term treatment and long-term follow-up better outcomes in improving sleep onset latency, total sleep time, sleep efficiency, anxiety, depression, and quality of life. Participants of the active acupuncture group had a pronouncedly higher cessation rate of sleeping medications than the sham control (56.5% vs. 14.3%, P = 0.011). All treatment-related adverse events were mild. No participants discontinued treatments due to adverse events. Conclusion The active acupuncture regimen could be considered as an effective option for the management of chemotherapy-associated insomnia. It also could serve as a tapering approach to reduce and even replace the use of sleeping medications in breast cancer patients. Trial registrationClinicaltrials.gov: NCT04144309. Registered 30 October 2019.

show abstract

Section: Discussionmentioning

confidence: 99%

Acupuncture for chemotherapy-associated insomnia in breast cancer patients: an assessor-participant blinded, randomized, sham-controlled trial

Zhang

Qin

et al. 2023

Breast Cancer Res

View full text Add to dashboard Cite

show abstract

“…Patients described a cyclical loop where lack of sleep caused more fatigue, which prevented them from walking for exercise. Sleep quality in cancer dependents on multiple parameters such as fatigue, pain, depression, anxiety and distress 19 and so is hard to interpret. Nevertheless, a recent systematic review showed that improving sleep quality eased the symptoms of cancer-related fatigue although was unable to determine if sleep quality improvement was the sole factor behind fatigue lessening.…”

Section: Discussionmentioning

confidence: 99%

Patient Willingness to Use Digital Health Technologies: A Quantitative and Qualitative Survey in Patients with Cancer Cachexia

Tarachandani¹,

Karahanoğlu²,

Messere³

et al. 2023

PPA

View full text Add to dashboard Cite

Purpose The objective of this study was to gain insights into the patients’ perspectives on the impact of cancer cachexia on physical activity and their willingness to wear digital health technology (DHT) devices in clinical trials. Patients and Methods We administered a quantitative 20-minute online survey on aspects of physical activity (on a 0–100 scale) to 50 patients with cancer cachexia recruited through Rare Patient Voice, LLC. A subset of 10 patients took part in qualitative 45-minute web-based interviews with a demonstration of DHT devices. Survey questions related to the impact of weight loss (a key characteristic in Fearon’s cachexia definition) on physical activity, patients’ expectations regarding desired improvements and their level of meaningful activities, as well as preferences for DHT. Results Seventy-eight percent of patients reported that their physical activity was impacted by cachexia, and for 77% of them, such impact was consistent over time. Patients perceived most impact of weight loss on walking distance, time and speed, and on level of activity during the day. Sleep, activity level, walking quality and distance were identified as the most meaningful activities to improve. Patients would like to see a moderate improvement of activity levels and consider it meaningful to perform physical activity of moderate intensity (eg, walk at normal pace) on a regular basis. The wrist was the preferred location for wearing a DHT device, followed by arm, ankle, and waist. Conclusion Most patients reported physical activity limitations since the occurrence of weight loss compatible with cancer-associated cachexia. Walking distance, sleep and quality of walk were the most meaningful activities to moderately improve, and patients consider moderate physical activity as meaningful. Finally, this study population found the proposed wear of DHT devices on the wrist and around the waist acceptable for the duration of clinical studies.

show abstract

“…Although a relatively strong body of evidence exists to support the role of the microbiota, and indeed SCFAs in modulating the toxicities described above, emerging data is now beginning to suggest a possible role in psychoneurological symptoms. This cluster of related symptoms includes cognitive impairments affecting memory, executive function, processing speeds, and learning [ 110 , 111 , 112 ], as well as psychological elements including depression/anxiety, fear of recurrence, and personality changes [ 113 , 114 ]. Although the current evidence is limited, this mechanism is supported by: i) changes in the gut microbiota that coincide with psychoneurological symptoms in people with cancer, and ii) direct involvement of SCFAs in other neurological conditions that share similar symptom profiles.…”

Section: Scfas and Cancer Treatment Toxicitiesmentioning

confidence: 99%

Gut Microbiota-Derived Short-Chain Fatty Acids: Impact on Cancer Treatment Response and Toxicities

et al. 2022

View full text Add to dashboard Cite

The gut microbiota has emerged as a key modulator of cancer treatment responses in terms of both efficacy and toxicity. This effect is clearly mediated by processes impacting the activation and modulation of immune responses. More recently, the ability to regulate chemotherapeutic drug metabolism has also emerged as a key driver of response, although the direct mechanisms have yet to be fully elucidated. Through fermentation, the gut microbiota can produce several types of metabolites, including short-chain fatty acids (SCFAs). SCFAs play an important role in maintaining epithelial barrier functions and intestinal homeostasis, with recent work suggesting that SCFAs can modulate response to cancer treatments and influence both anti-tumor immune response and inflammatory-related side effects. In this review, we will discuss the importance of SCFAs and their implications for cancer treatment response and toxicities.

show abstract

Factors associated with sleep quality during chemotherapy: An integrative review

Cited by 26 publications

References 58 publications

Acupuncture for chemotherapy-associated insomnia in breast cancer patients: an assessor-participant blinded, randomized, sham-controlled trial

Acupuncture for chemotherapy-associated insomnia in breast cancer patients: an assessor-participant blinded, randomized, sham-controlled trial

Patient Willingness to Use Digital Health Technologies: A Quantitative and Qualitative Survey in Patients with Cancer Cachexia

Gut Microbiota-Derived Short-Chain Fatty Acids: Impact on Cancer Treatment Response and Toxicities

Contact Info

Product

Resources

About