Factors Prognostic of Survival in Patients Awaiting Liver Transplantation for End-Stage Liver Disease

Şelçuk, Haldun; Uruc, Irfan; Temel, Mehtap Akcil; Öcal, Serkan; Huddam, Bülent; Korkmaz, Murat; Ünal, Hakan; Kanbay, Mehmet; Savas, Nurten; Gür, Gürden; Yılmaz, Uğur; Haberal, Mehmet

doi:10.1007/s10620-007-9742-3

Cited by 21 publications

(15 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Racial disparities and dietary differences are possible causes for the difference in lipid metabolism between the cited studies. Some studies assess the prognostic importance of lipids in liver cirrhosis patients, observing that lower serum levels related to more advanced hepatic disease and higher mortality rates (14,35) .…”

Section: Discussionmentioning

confidence: 99%

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Port

Oliveira

Soldera

et al. 2014

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Context -Liver cirrhosis patients with hepatocellular carcinoma present nutritional alterations and metabolic disorders that negatively impact the prognosis. Objective -The objective is to identify alterations in the metabolism of macro and micronutrients among liver cirrhosis patients with and without hepatocellular carcinoma and their relation to the Child-Turcote-Pugh score and Barcelona Clinic Liver Cancer staging. Methods -Analytical transversal study, with 31 hepatocellular carcinoma patients and 48 liver cirrhosis patients. Laboratorial exams were carried out. The existence of an association between the biochemical parameters and the disease severity as well as the presence of hepatocellular carcinoma was assessed. Results -The metabolic-nutritional profile of liver cirrhosis patients caused by the hepatitis C virus and hepatocellular carcinoma showed alterations, specifically the lipid (total cholesterol, HDL and triglycerides), protein (albumin, creatinine and uric acid), iron (transferrin, iron and ferritin saturation), hematocrit and hemoglobin, zinc and B12 vitamin profiles. There is a relation between nutritional biochemical markers and the Child-Turcote-Pugh, as well as Barcelona Clinic Liver Cancer staging. Conclusion -Considering the existence of alterations in the metabolism of nutrients in liver cirrhosis patients with and without hepatocellular carcinoma, and also that conventional nutritional assessment methods present limitations for this population, the biochemical laboratorial exams are valid to complement the diagnosis of the nutritional state in a quick and practical manner.

show abstract

Section: Discussionmentioning

confidence: 99%

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Port

Oliveira

Soldera

et al. 2014

Arq. Gastroenterol.

View full text Add to dashboard Cite

show abstract

“…Several other laboratory variables not included in these have been studied in adult ALF including alpha-fetoprotein (19,20), phosphorus (21), ammonia (22), lactate (23), and the APACHE II score (24). Adding serum sodium values to the MELD score has also received attention for predicting survival in chronic liver failure (25–28). We analyzed admission sodium values and did not find a correlation to outcome in PALF.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Scoring System for Assessing Prognosis in Pediatric Acute Liver Failure

Lu¹,

Gralla²,

Liu³

et al. 2008

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

Background & Aims-Pediatric acute liver failure (PALF) results in death or need for liver transplantation (LT) in up to 50% of patients. A scoring system for predicting death or LT [Liver Injury Units (LIU) score] in PALF was previously derived by our group, and used peak values during hospital admission of total bilirubin, prothrombin time/international normalized ratio, and ammonia as significant predictors of outcome. The aims of this study were to test the predictive value of the LIU score in a subsequent validation set of patients and to derive a hospital admission score (aLIU) predictive of outcome.

show abstract

“…However, in Selcuk et al's [16] study, they focused on the association between survival time, which was defined as the total number of days between a patient's admission date and his or her death, and levels of serum sodium, cholesterol, albumin, and platelet count in 99 patients (79 men and 20 women); their mean age at the end of followup was 58.76 + 15.76 years and had different etiologies. Those who died from other causes such as myocardial infarction, traffic accident, or fulminant hepatic failure were excluded from the study, whereas those who were diagnosed as having hepatocellular carcinoma or concomitant disease such as diabetes mellitus, arterial hypertension, and coronary artery disease were enrolled in the study.…”

Section: Before 3 Months After 3 Monthsmentioning

confidence: 99%

Addition of ‘serum sodium’ as a variable in the ‘model for end-stage liver disease’ scoring system

Montasser¹,

Moez²,

El-Folly³

et al. 2014

Egyptian Liver Journal

View full text Add to dashboard Cite

AimThe aim of the study was to evaluate the addition of serum sodium to the model for end-stage liver disease (MELD) score as a prognostic factor for survival in patients with decompensated liver cirrhosis. Patients and methods Sixty patients with posthepatitis C virus decompensated liver disease were included. They were Child class B or C according to the Child-Pugh classification. The following investigations were performed for all patients: complete blood count, liver function tests, serum sodium, and abdominal ultrasonography. MELD score and MELD-Na were calculated for all patients. All patients were followed up after 3 months clinically and by laboratory analysis. Results A significant increase in class C patients after 3 months (Po0.05) was detected. There was no statistical significant difference between MELD-Na and MELD scores, either at onset or after 3 months (P40.05). MELD score was more reliable to predict mortality (Po0.05). For prediction of mortality, the best cutoff value for MELD score was 20 with a sensitivity of 71% and specificity of 75%, whereas the best cutoff value for MELD-Na was 30 with a sensitivity of 70% and specificity of 58%. There was a statistically significant difference between living and dead patients with respect to the distribution of MELD score and Child classification, whereas no statistically significant difference between living and dead patients with respect to the distribution of MELD-Na was found. Conclusion MELD score is more reliable at prediction of mortality than MELD-Na, and the best cutoff value for MELD score is 20, whereas the best cutoff value for MELD-Na is 30. The study could not elicit a value of adding serum sodium to the MELD scoring system. Keywords:decompensated liver disease, model for end-stage liver disease, model for end-stage liver disease-Na, survival Receiver operating characteristic (ROC) curve to define the best cutoff of model for end-stage liver disease (MELD)-Na and MELD scores to predict mortality.'Serum sodium' as a variable in the MELD Montasser et al. 33

show abstract

Factors Prognostic of Survival in Patients Awaiting Liver Transplantation for End-Stage Liver Disease

Cited by 21 publications

References 15 publications

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Evaluation of a Scoring System for Assessing Prognosis in Pediatric Acute Liver Failure

Addition of ‘serum sodium’ as a variable in the ‘model for end-stage liver disease’ scoring system

Contact Info

Product

Resources

About