Failure of Phyllanthus amarus to eradicate hepatitis B surface antigen from symptomless carriers

Leelarasamee, Amorn; Trakulsomboon, Suwanna; Maunwongyathi, Payow; Somanabandhu, Aimon; Pidetcha, Phannee; Matrakool, Busaba; Lebnak, Tassnee; Ridthimat, Watana; Chandanayingyong, Dasnayanee

doi:10.1016/0140-6736(90)91436-e

Cited by 45 publications

(24 citation statements)

References 2 publications

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“…Specifically, Thyagarajan et al [2002] found that the HBV surface antigen (HBsAg) level of 59% of HBV carriers became negative after 9-month treatments with P. amarus collected from India, compared with only 4% in the placebo group [Thyagarajan et al, 1988]. However, another study failed to reproduce this result, finding no difference in HBsAg and HBV e antigen (HBeAg) seroconversion [Leelarasamee et al, 1990]. Subsequently, P. urinaria L., which belongs to the same genus, has also been reported to exhibit anti-HBV effects [Liu et al, 1997].…”

mentioning

confidence: 79%

Antiviral effect of Phyllanthus nanus ethanolic extract against hepatitis B virus (HBV) by expression microarray analysis

Lam

Leung

Law

et al. 2005

J of Cellular Biochemistry

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Ethanolic extract of Phyllanthus nanus (P. nanus) treatment exhibited potent antiviral activity against Hepatitis B virus (HBV). The effects of these extracts on HBV in the HBV genome integrated cell lines--Alexander cells and HepG2 2.2.15 cells were examined. Experimental results showed that the ethanolic extract of P. nanus produced suppressive effect on HBsAg secretion and HBsAg mRNA expression. The extract also inhibited HBV replication as measured by HBV DNA level in vitro. In addition, using a duck HBV (DHBV) primary culture model, the P. nanus ethanolic extract suppressed viral replication of DHBV in DHBV infected primary duck hepatocytes. The gene expression pattern in Alexander cells that had been treated with the ethanolic extract of P. nanus was also revealed by microarray techniques. The microarray results indicated that there was up-regulation of expression of several genes, including annexin A7 (Axn7). The subcellular localization of Axn7 and anti-HBV effect of Axn7 over-expression in Alexander cells were also investigated. Results showed that expression of Axn7-GFP fusion protein are localized around the secretory vesicles and could cause a decrease in HBsAg secretion in Alexander cells. Axn7 protein might play an important role in the medicinal effect of the active principle(s) of P. nanus.

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mentioning

confidence: 79%

Antiviral effect of Phyllanthus nanus ethanolic extract against hepatitis B virus (HBV) by expression microarray analysis

Lam

Leung

Law

et al. 2005

J of Cellular Biochemistry

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“…7) are most commonly used; however, the whole plant or the roots are also used for certain purposes in some manuscripts. A. paniculata has been reported as having antibacterial (Leelarasamee et al, 1990), anti malarial (Dua et al, 2004), antiviral (Wiart et al, 2005), cardioprotective, antioxidant, anti-inflammatory (Sheeja et al, 2006), antidiabetic effects and also antitumor activities (Zhao et al, 2008). Treatment with whole plant extract of A. paniculata effectively reduced the level of lipid peroxidation and increased the status of antioxidant enzymes.…”

Section: Andrographis Paniculata (King Of Bitters)mentioning

confidence: 97%

Physiological changes due to hepatotoxicity and the protective role of some medicinal plants

Seif

2016

Beni-Suef University Journal of Basic and Applied Sciences

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“…There are negative studies as well, reporting no efficacy of P. amarus in chronic HBV carriers (14)(15)(16)(17)(18). The discrepancy between these studies could be related to different varieties of P. amarus being used (1, 14-18), which may not contain biological active substances (1).…”

Section: Phyllanthusmentioning

confidence: 97%

Herbal Medicines for Liver Diseases

2005

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Herbal medicines have been used in the treatment of liver diseases for a long time. A number of herbal preparations are available in the market. This article reviews four commonly used herbal preparations: (1) Phyllanthus, (2) Silybum marianum (milk thistle), (3) glycyrrhizin (licorice root extract), and (4) Liv 52 (mixture of herbs). Phyllanthus has a positive effect on clearance of HBV markers and there are no major adverse effects; there are no data from randomized controlled trials on clinically relevant outcomes, such as progression of chronic hepatitis to cirrhosis and/or liver cancer, and on survival. Silymarin does not reduce mortality and does not improve biochemistry and histology among patients with chronic liver disease; however, it appears to be safe and well tolerated. Stronger neominophagen C (SNMC) is a Japanese preparation that contains 0.2% glycyrrhizin, 0.1% cysteine, and 2% glyceine. SNMC does not have antiviral properties; it primarily acts as an anti-inflammatory or cytoprotective drug. It improves mortality in patients with subacute liver failure and improves liver functions in patients with subacute hepatic failure, chronic hepatitis, and cirrhosis with activity. SNMC does not reduce mortality among patients with cirrhosis with activity. SNMC may prevent the development of hepatocellular carcinoma in patients with chronic hepatitis C, however, prospective data are lacking. Liv 52, an Ayurvedic hepatoprotective agent, is not useful in the management of alcohol-induced liver disease. Standardization of herbal medicines has been a problem and prospective, randomized, placebo-controlled clinical trials are lacking to support their efficacy. The methodological qualities of clinical trials of treatment with herbal preparations are poor. The efficacy of these herbal preparations need to be evaluated in rigorously designed, larger randomized, double-blind, placebo-controlled multicenter trials.

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Failure of Phyllanthus amarus to eradicate hepatitis B surface antigen from symptomless carriers

Cited by 45 publications

References 2 publications

Antiviral effect of Phyllanthus nanus ethanolic extract against hepatitis B virus (HBV) by expression microarray analysis

Antiviral effect of Phyllanthus nanus ethanolic extract against hepatitis B virus (HBV) by expression microarray analysis

Physiological changes due to hepatotoxicity and the protective role of some medicinal plants

Herbal Medicines for Liver Diseases

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