1978
DOI: 10.2214/ajr.130.1.131
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False negative bone scans in neuroblastoma metastatic to the ends of long bones

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Cited by 44 publications
(11 citation statements)
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“…Skeletal surveys have previously been recommended for infants with negative bone scan fi ndings ( 7,43 ). However, in our experience, these rarely add important information and accordingly are not considered helpful.…”
Section: Special Report: Guidelines For Imaging and Staging Neuroblasmentioning
confidence: 98%
See 1 more Smart Citation
“…Skeletal surveys have previously been recommended for infants with negative bone scan fi ndings ( 7,43 ). However, in our experience, these rarely add important information and accordingly are not considered helpful.…”
Section: Special Report: Guidelines For Imaging and Staging Neuroblasmentioning
confidence: 98%
“…Bone scan has a reported sensitivity of 70%-78% and a specifi city of 51% for the detection of bone metastases ( 38,42 ). The high physiologic uptake of the growing metaphyses in children, especially infants, may be misinterpreted as metastases or hide small metastases ( 43 ).…”
Section: Special Report: Guidelines For Imaging and Staging Neuroblasmentioning
confidence: 99%
“…However, some studies have pointed out the potential of false negative bone scintigraphy [41,65]. In one study, the conventional skeletal survey was more sensitive than bone scintigraphy, especially when metastases involve the metaphyseal regions [41].…”
Section: Skeletal Metastasesmentioning
confidence: 99%
“…However, some studies have pointed out the potential of false negative bone scintigraphy [41,65]. In one study, the conventional skeletal survey was more sensitive than bone scintigraphy, especially when metastases involve the metaphyseal regions [41]. Skeletal scintigraphy has a false-positive rate of approximately 5-I0%, but combining skeletal scintigraphy with bone marrow aspiration markedly increases specificity [32,65].…”
Section: Skeletal Metastasesmentioning
confidence: 99%
“…It is critical to have precise staging of the disease at diagnosis and follow-up to ensure the most appropriate treatment plan. Bone-avid agents, such as 99m Tc-MDP, have been shown to localize in osseous neuroblastoma deposits, [10][11][12][13][14][15] particularly in cortical bone. Later, MIBG was found to be highly sensitive for the localization of neuroblastoma, particularly in soft tissues and bone marrow, and its use has become the standard of care.…”
Section: Introductionmentioning
confidence: 99%