Fast liquid chromatography: The domination of core?shell and very fine particles

Fekete, Szabolcs; Oláh, Erzsébet; Fekete, Jenő

doi:10.1016/j.chroma.2011.09.050

Cited by 236 publications

(135 citation statements)

References 120 publications

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“…The rationale behind this concept was to improve the column efficiency by shortening the diffusion path that analyte molecules must travel and, in doing so, to improve their mass transfer kinetics [5,93]. The concept of shell-type (pellicular) particles was imagined by Horváth and coworkers in the late 60s [94].…”

Section: Superficially Porous Particlesmentioning

confidence: 99%

“…As reported in (Fig. 1), various types of innovative material were commercially introduced or revisited, including silica-based monoliths in 2000 [1,2], columns packed with fully porous sub-2 m in [3,4], and columns packed with core-shell sub-3 m in 2007 [5,6]. Using these approaches, it is indeed possible to strongly increase throughput and/or resolution in LC.…”

Section: Introductionmentioning

confidence: 99%

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Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Fekete¹,

Perrenoud²,

Guillarme

2014

CCHG

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Abstract:The current trend in high performance liquid chromatography (HPLC) tends toward the achievement of higher separation efficiency and shorter analysis time. Indeed, better performance in LC has become increasingly important in recent years mainly driven by the challenges of either analyzing more complex samples or increasing the numbers of samples per time unit. In the recent development of particle technology, the use of fully porous sub-2 m particles and sub-3 m shell particles have received considerable attention. Beside packed columns, the new generation of silica-based monolithic columns also offers very high separation power. However, to take full advantage of these innovative phases, the chromatographic system has also to be drastically optimized in terms of upper pressure limit and system volume.This revolution in column technology now spreads and covers several modes of liquid chromatography such as reversedphase liquid chromatography (RPLC), hydrophilic interaction liquid chromatography (HILIC), or even supercritical fluid chromatography (SFC). The HILIC and SFC, which can be considered as alternative modes of chromatography, could also be useful to extend the applicability of chromatography towards the analysis of very hydrophilic and lipophilic compounds, respectively.The present review gives an insight about the theory behind the success of current column technology and presents a summary of latest applications, using various modes of one-dimensional chromatography (RPLC, HILIC, SFC). This paper also shows that theoretically expected column efficiency could sometimes be compromised in practical work especially in the case of narrow bore columns.

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Section: Superficially Porous Particlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Fekete¹,

Perrenoud²,

Guillarme

2014

CCHG

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“…In addition, a strong impact of instrument configuration on the experimental hen curves was observed (Gritti et al, 2014) for narrow bore columns. In a review by Fekete et al (2012), h min values for various coreeshell and fully porous particle have been summarized. Packed in 4.6 mm I.D.…”

Section: Coreeshell Particles 193mentioning

confidence: 99%

Theory and Practice of UHPLC and UHPLC–MS

Guillarme

Veuthey

2017

Handbook of Advanced Chromatography /Mass Spectrometry Techniques

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“…Coreshell particles are composed of nonporous silica core and porous silica shell, and they are also called superficially porous particles. The layer-by-layer self assembly technique is in general incorporated to make core-shell particles 2,3,12 while spray-drying was adopted in the preparation of old type commercialized core-shell particles. 13 Concerning the Abbreviations: BPA, bisphenol A; BTEE, 1,2-bis(triethoxysilyl)ethane; BTME, 1,2 bis(trimethoxysilyl) ethane; 4-CPI, 4-chloromehtylphenylisocynate; CTAB; cetyltrimethylammonium bromide; DPA, Diphenolic Acid; HETP, height equivalent to theoretical plate; HILIC, hydrophilic interaction chromatography; MIP, molecularly imprinted polymer; pCEC, pressurized capillary electrochromtography; PES, poly-ethoxysilane; PMOs, periodic mesopororous organosilicas; PSS, poly(sodium-p-styrenesulfonate); RAFT, reversible addition fragmentation transfer; SDS, sodium dodecyl sulfate; SEC, size exclusion chromatography; TBBPA, tetrabromobisphenol A; TEOS, tetraethoxysilane; UHPLC, ultra high pressure liquid chromatography.…”

Section: Core-shell Silica Particlesmentioning

confidence: 99%

“…Superficially porous (core/ shell) sub-3 µm silica particles have also been prepared recently. 2,3,7,10,[19][20][21][22][23][24][25][26][27][28][29][30] Nonporous Silica Particles. Nonporous silica particles have been used for quick separation of peptides and proteins.…”

Section: Sub 3 µM Silica Particlesmentioning

confidence: 99%

Porous Silica Particles As Chromatographic Separation Media: A Review

Cheong¹

2014

Bulletin of the Korean Chemical Society

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Porous silica particles are the most prevailing raw material for stationary phases of liquid chromatography. During a long period of time, various methodologies for production of porous silica particles have been proposed, such as crashing and sieving of xerogel, traditional dry or wet process preparation of conventional spherical particles, preparation of hierarchical mesoporous particles by template-mediated pore formation, repeated formation of a thin layer of porous silica upon nonporous silica core (core-shell particles), and formation of specific silica monolith followed by grinding and calcination. Recent developments and applications of useful porous silica particles will be covered in this review. Discussion on sub-3 µm silica particles including nonporous silica particles, carbon or metal oxide clad silica particles, and molecularly imprinted silica particles, will also be included. Next, the individual preparation methods and their feasibilities will be collectively and critically compared and evaluated, being followed by conclusive remarks and future perspectives.

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Fast liquid chromatography: The domination of core?shell and very fine particles

Cited by 236 publications

References 120 publications

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Theory and Practice of UHPLC and UHPLC–MS

Porous Silica Particles As Chromatographic Separation Media: A Review

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