Ferulic acid inhibits UVB-radiation induced photocarcinogenesis through modulating inflammatory and apoptotic signaling in Swiss albino mice

Ambothi, Kanagalakshmi; Prasad, Nagarajan Rajendra; Balupillai, Agilan

doi:10.1016/j.fct.2015.04.031

Cited by 59 publications

(43 citation statements)

References 37 publications

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“…A previous study found that UVB‐exposed MMP‐1, which could be impaired by TGF‐β1, plays a vital role in collagen degradation. UVB irradiation stimulates pro‐inflammatory cytokine IL‐6 secretion, which upregulates expression level of MMP‐1, further leading to upregulation of the TNF‐α and VEGF by cascade reactions . As expected, ginsenoside C‐Y impaired the UVB irradiation expression levels of IL‐6, TNF‐α and VEGF.…”

Section: Discussionsupporting

confidence: 70%

Antiphotoaging and Antimelanogenesis Properties of Ginsenoside C‐Y, a Ginsenoside Rb2 Metabolite from American Ginseng PDD‐ginsenoside

Liu

Xiao

Hwang

et al. 2019

Photochem & Photobiology

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Ginsenosides are compounds responsible for the primary pharmacological effects of American ginseng. Compound‐Y (C‐Y) is a minor ginsenoside and a metabolite of Panax ginseng. In this study, we investigated the protective effect of ginsenoside UVB‐irradiated NHDFs and its potential for use as an antihyperpigmentation agent through ginsenoside C‐Y as a functional food and cosmetic ingredient. Ginsenoside C‐Y is a natural antioxidant isolated from the American ginseng PDD‐ginsenoside. Our data showed that ginsenoside C‐Y block UVB‐exposed ROS, restrict MMP‐1 production and promote procollagen type I synthesis. Interestingly, ginsenoside C‐Y suppresses UVB‐exposed VEGF, and TNF‐α secretion, could be related with NFAT signal path. Ginsenoside C‐Y has exhibited photoaging effects by increasing TGF‐β1 level, fortifying Nrf2 nuclear translocation and restricting AP‐1 and MAPK phosphorylation. Assessment of the melanogenic response indicated that ginsenoside C‐Y inhibited melanin secretion and tyrosinase activity and decreased melanin content in Melan‐a and zebrafish embryos. These results suggest that ginsenoside C‐Y can be used as a potential botanical agent to protect premature skin from UVB‐induced photodamage and prevent skin hyperpigmentation.

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Section: Discussionsupporting

confidence: 70%

Antiphotoaging and Antimelanogenesis Properties of Ginsenoside C‐Y, a Ginsenoside Rb2 Metabolite from American Ginseng PDD‐ginsenoside

Liu

Xiao

Hwang

et al. 2019

Photochem & Photobiology

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“…FA induced an increased expression of Bax accompanied with a significant decreased expression of Bcl-2 in the MIA PaCa-2 cells 15. It is reported that FA could increase expression of Bax with concomitant decreased Bcl-2 in the photocarcinogenesis progress of male Swiss albino mice skin 20. It is also discovered that Bax was prominently up-regulated while Bcl-2 was down-regulated in T24 bladder cancer cells cultured with FA 16.…”

Section: Discussionmentioning

confidence: 96%

Ferulic acid promoting apoptosis in human osteosarcoma cell lines

Zhang¹,

Wu²,

Yang³

2017

Pak J Med Sci

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Objective:To explore the promoting apoptosis and antitumor activities of ferulic acid (FA) in human osteosarcoma and its potential mechanism.Methods:The SaOS-2 and MG63 osteosarcoma cell lines were opted to experiment and these cells were, respectively, cultured with various concentrations of FA (0 μM, 10 μM, 20 μM, 40 μM) for 72 hours at 37°C. The viabilities of the FA treated cells were monitored by MTT. Apoptosis cells were evaluated using annexin V/PI by flow cytometry. Apoptosis proteins caspase-3, procaspase-3, Bcl-2 and Bax were detected by western blot. Expressions of apoptotic genes Bcl-2 and Bax were quantified by qPCR.Results:The cell viabilities were critically declined in the concentration-dependent manner in FA groups (P < 0.01). The apoptosis cells were increased proportionately with the concentration of FA (P < 0.05). The procaspase-3 protein contents, and Bcl-2 mRNA and protein contents were significantly decreased while caspase-3 protein contents, and Bax mRNA and protein contents were concomitantly increased in the concentration-dependent manner in FA groups (P < 0.05). The response to FA by the SaOS-2 osteosarcoma cell was similar with the MG63 osteosarcoma cell (P > 0.05).Conclusion:Ferulic acid could significantly descend osteosarcoma cell viability through the promoting apoptosis pathway in which FA activates both caspase-3 and Bax and inactivates Bcl-2.

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“…Furthermore, we observed increased TBARS levels in UVB-irradiated cells with concomitant decrease of SOD, catalase and GPX activities. Lipid peroxidation and loss of antioxidants generated by UVB-radiation has been known to be potentially deleterious for cellular function, having cytotoxic effects, cell membrane damage and apoptosis [28]. Monoterpenes are powerful antioxidants and alleviated free radical mediated alterations in several in vitro and in vivo models [29].…”

Section: Discussionmentioning

confidence: 99%

Linalool prevents oxidative stress activated protein kinases in single UVB-exposed human skin cells

et al. 2017

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Ultraviolet-B radiation (285–320 nm) elicits a number of cellular signaling elements. We investigated the preventive effect of linalool, a natural monoterpene, against UVB-induced oxidative imbalance, activation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B (NF-κB) signaling in HDFa cells. We observed that linalool treatment (30 μM) prevented acute UVB-irradiation (20 mJ/cm2) mediated loss of activities of antioxidant enzymes in HDFa cells. The comet assay results illustrate that linalool significantly prevents UVB-mediated 8-deoxy guanosine formation (oxidative DNA damage) rather than UVB-induced cyclobutane pyrimidine (CPD) formation. This might be due to its ability to prevent UVB-induced ROS formation and to restore the oxidative imbalance of cells. This has been reflected in UVB-induced overexpression of MAPK and NF-κB signaling. We observed that linalool inhibited UVB-induced phosphorylation of ERK1, JNK and p38 proteins of MAPK family. Linalool inhibited UVB-induced activation of NF-κB/p65 by activating IκBa. We further observed that UVB-induced expression of TNF-α, IL6, IL-10, MMP-2 and MMP-9 was modulated by linalool treatment in HDFa cells. Thus, linalool protects the human skin cells from the oxidative damages of UVB radiation and modulates MAPK and NF-κB signaling in HDFa cells. The present findings substantiate that linalool may act as a photoprotective agent against UVB-induced skin damages.

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Ferulic acid inhibits UVB-radiation induced photocarcinogenesis through modulating inflammatory and apoptotic signaling in Swiss albino mice

Cited by 59 publications

References 37 publications

Antiphotoaging and Antimelanogenesis Properties of Ginsenoside C‐Y, a Ginsenoside Rb2 Metabolite from American Ginseng PDD‐ginsenoside

Antiphotoaging and Antimelanogenesis Properties of Ginsenoside C‐Y, a Ginsenoside Rb2 Metabolite from American Ginseng PDD‐ginsenoside

Ferulic acid promoting apoptosis in human osteosarcoma cell lines

Linalool prevents oxidative stress activated protein kinases in single UVB-exposed human skin cells

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