FICZ, a Tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma

Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function

“…10,39,40 In these models, AhR activation led to reduced eosinophilia, inhibited Th2 and challenged with OVA as described, and total and OVA-specific IgE and IgG1 was measured in serum as described. 31 (a) Total IgE,…”

The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology

“…Autoimmunity is driven by Th17 cells and ameliorated or prevented by antigen-specific regulatory T cells. In the Du et al, 2005;Fritsche et al, 2007;Kostyuk et al, 2012;John et al, 2013Smith et al, 2013 Circadian rhythmicity Mukai and Tischkau, 2007 Expression of AhR target genes Wei et al, 2000;Oberg et al, 2005;Sciullo et al, 2008;Nair et al, 2009;Wincent et al, 2009;Lee et al, 2010;Luecke et al, 2010;Mohammadi-Bardbori et al, 2012;Rico-Leo et al, 2013;Sumida et al, 2013Jönsson et al, 2009Laub et al, 2010;Wincent et al, 2012;Odio et al, 2013 Genome rearrangement Okudaira et al, 2010Okudaira et al, , 2013 Immune response Apetoh et al, 2010;Bankoti et al, 2010Quintana et al, 2008Veldhoen et al, 2008;Martin et al, 2009;Monteleone et al, 2011;Jeong et al, 2012;Pauly et al, 2012;Qiu et al, 2012;Sibilano et al, 2012;Duarte et al, 2013;Wheeler et al, 2013;Zhou et al, 2013 Nuclear receptor cross-talk Ekins et al, 2008;Reschly et al, 2008;Bunaciu and Yen, 2013 AhR activation can also occur by factors that block/inhibit CYP1A, leading to exceptionally high FICZ levels because FICZ is no longer degraded. In both scenarios (B) and (C), FICZ homeostastic...…”

Aryl Hydrocarbon Receptor Control of Adaptive Immunity

“…Since then, many studies have demonstrated that 6-formylindolo [3,2-b]carbazole (FICZ) binds to the AhR with high affinity and initiates AhR signaling at nanomolar concentrations (Rannug et al, 1987;Wei et al, 1999Wei et al, , 2000Oberg et al, 2005;Goryo et al, 2007;Mukai and Tischkau, 2007;Wincent et al, 2009Wincent et al, , 2012. FICZ can contribute to (Kostyuk et al, 2012) or block (Jeong et al, 2012) inflammatory responses in a tissue-and context-specific fashion. FICZ also influences responses to ultraviolet light, genomic stability, and circadian rhythms, all postulated to be AhR mediated (Wincent et al, 2012).…”