Fifteen different 18F-FDG PET/CT qualitative and quantitative parameters investigated as pathological response predictors of locally advanced rectal cancer treated by neoadjuvant chemoradiation therapy

Abstract

FDG PET/CT can accurately stratify patients with LARC preoperatively, independently of the method chosen to interpret the images. Among many PET parameters, some of which are not immediately obtainable, the most commonly used in clinical practice (SUVmax after CRT and VRA) showed the best accuracy in predicting TRG.

Prognostic value of fluorine-18 fludeoxyglucose positron emission tomography parameters differs according to primary tumour location in small-cell lung cancer

“…The cut-off value was determined by referring to data reported in previous studies. [18][19][20][21][22][23] Each VOI for calculating MTV and TLG was first placed manually, paying careful attention not to include high physiological uptake, and then MTV was automatically extracted on a workstation. The summed MTV was produced as the WB-MTV.…”

Prediction of response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer

“…SUV-post < 3.7 and CEA-pre < 5.3ng/mL are independent predictors for response to CRT in univariate and multivariate analysis. The combination of SUV-post < 3.7 and CEA-pre < 5.3 ng/mL increased the specificity from 65% and 51.4% to 84.4% for downstaging and the specificity from 63.6% and 81.8% to 91.6% for pCR (29).…”

“…Therefore, before ADC can be used as a predictor clinically, large cohort studies are needed. Capirci et al (25) Martoni et al (26) Chennupati et al (27) Kim et al (28) Maffione et al (29) Everaert et al (32) No. SUVmax-post was a significant factor for prediction of downstaging and pCR (28).…”

“…SUVmax-post was a significant factor for prediction of downstaging and pCR (28). Maffione et al used 8 parameters to predict TRG and found SUVmax, MTV, TLG-post, RI, ΔMTV%, and ΔTLG% were significantly correlated with pathological treatment response (p < 0.01) while SUVmax-post had the highest sensitivity in predicting TRG (29). SUVmax is the most commonly studied metabolic parameter for semiquantitative analysis of glucose metabolism with PET-CT.…”

“…Various PET-CT parameters have been investigated: mean standardized uptake value (SUVmean), maximum SUV (SUVmax), ΔSUVmax (SUVmax-pre -SUVmaxpost), response index [RI, (SUV pre -SUV post )/SUV pre ), metabolic tumor volume (MTV), ΔMTV% (MTV pre -MTV post )/MTV pre , visual response assessment (VRA), and total lesion glycolysis (TLG, SUVmean × MTV) ( Table 2) (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). These studies were able to establish a correlation between PET-CT results and CRT response (22)(23)(24)(25)(26)(27)(28)(29)(30). Most studies used several parameters but found just one or two parameters correlated with CRT response (21)(22)(23)(24)(25)(26)(27).…”