Fine Needle Aspiration Biopsy and Immunostaining Findings in an Aggressive Inflammatory Myofibroblastic Tumor of the Lung

Hannah, Christina D.; Oliver, Dwight; Liu, Jing

doi:10.1159/000325726

Cited by 16 publications

(6 citation statements)

References 15 publications

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“…On extensive literature review, there have been only few cases where recurrence was reported postresection, but none of them reported of recurrence while on treatment. [12][13][14] CONCLUSIONS IMT is a rare tumor and this unique case report has highlighted a new presentation of recurrence after steroid therapy. CT scan played an important role in diagnosis, followed by pathology, which confirmed the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Lung

Schaeffer

Minai²,

Sharma³

et al. 2008

Journal of Thoracic Imaging

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We report a case of a patient with inflammatory myofibroblastic tumor of the lung, which recurred after steroid treatment. The diagnosis of the tumor was confirmed by a core needle lung biopsy and pathology. The patient was initiated on steroid therapy, which on complete response was slowly tapered and discontinued. Few months later, the patient presented with dyspnea again. Chest radiography and computed tomography scans depicted recurrence at the tumor resection site in the right lobe of lung and a new tumor in the left lower lobe. Restarting the steroid therapy, led to regression of the tumors at both sites. This is a rare case of inflammatory myofibroblastic tumor recurring poststeroid therapy and adds to the current clinical knowledge about this peculiar manifestation of this disease entity.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Lung

Schaeffer

Minai²,

Sharma³

et al. 2008

Journal of Thoracic Imaging

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“…Fine-needle aspiration biopsies may be suggestive of IMT, but are often not sufficient for confident diagnosis, and histopathologic material is often required. 22 Both percutaneous core and surgical biopsies are capable of providing the histopathologic material required for a proper diagnosis.…”

Section: Inflammatory Pseudotumor: Diagnosismentioning

confidence: 99%

A Calcified Mass Within the Thorax

Panse

Jensen

Cummings

et al. 2016

Clinical Pulmonary Medicine

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Inflammatory myofibroblastic tumor (IMT) is a rare proliferative lesion also referred to as an inflammatory pseudotumor, among a number of other pseudonyms. IMTs are comprised of variable amounts of spindle cells, collagen, and inflammatory cells, including plasma cells, foamy histiocytes, and lymphocytes. IMTs may affect different organ systems, but the thorax is the most commonly affected, particularly the lung or the airways, and less commonly the mediastinum. IMTs exhibit a variable biological behavior, ranging from spontaneous involution to locally aggressive behavior, including recurrence after resection, regional extension, and even distant metastatic deposits. Genetic assessment has revealed neoplastic features in some IMTs, but not others, rendering the IMT classification ambiguous. Pulmonary IMTs affect patients over a wide age range, but are most frequently encountered in children, adolescents, or young adults. IMTs are occasionally discovered asymptomatically, but may present fever, dyspnea, chest pain, or hemoptysis. Thoracic IMTs primarily present on imaging as a solitary pulmonary nodule or mass, which may show calcification: an appearance suggestive of IMT when a nodule or a mass is encountered in a young patient. The margins of thoracic IMTs range from circumscribed to lobulated or poorly defined. Intense contrast enhancement is common with IMTs, and the lesions may even be associated with aberrant systemic arterial supply, simulating pulmonary sequestration. Thoracic IMTs are usually treated with limited surgical resection, with corticosteroid therapy or radiation utilized for unresectable patients or patients with inadequate surgical margins.

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“…Scars have less cellularity and greater cohesion with more angulated nuclei. 16,104,105 The tumor cells are positive for actin and occasionally positive for desmin and keratin. The cells of DFSP lack the typical blunt end nuclei of smooth muscle tumors and are negative for smooth muscle markers.…”

Section: Differential Diagnosis Of Dermatofibrosarcoma Perturbansmentioning

confidence: 99%

Soft Tissue

Qian¹

2009

Cytology

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Fine Needle Aspiration Biopsy and Immunostaining Findings in an Aggressive Inflammatory Myofibroblastic Tumor of the Lung

Cited by 16 publications

References 15 publications

Inflammatory Myofibroblastic Tumor of the Lung

Inflammatory Myofibroblastic Tumor of the Lung

A Calcified Mass Within the Thorax

Soft Tissue

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