Fingerprinting and iso-absorptive resolution techniques for the spectrally overlapping Dutasteride and Silodosin mixture: Content uniformity testing along with greenness profile assessment

Novel sensing probe using Terbium-sensitized luminescence and 8-hydroxyquinoline for determination of prucalopride succinate: green assessment with Complex-GAPI and analytical Eco-Scale

“…It is an update of the commonly used metric called GAPI [ 27 ]. The index provide a widely used metric to evaluate the analytical method greenness [ 28 , 29 ]. This assessment is represented with five pentagrams which provide a comprehensive evaluation of the entire methodology; starting from sample collection and preparation, solvents and reagents used, the instrumentation, the waste produced and the energy consumption.…”

Sustainable spectrophotometric determination of antihypertensive medicines reducing COVID-19 risk via paired wavelength data processing technique - Assessment of purity, greenness and whiteness

“…Mathematical spectrophotometric methods using built in spectrophotometer's software are now being utilized more frequently for evaluation of drugs in pharmaceutical formulations ( Obaydo et al, 2021 ; Lotfy and Saleh, 2016 ; Saleh et al, 2022 ; Rostom et al, 2021 , 2022 ; Lotfy and Hagazy, 2012 ; Lotfy and Omran, 2018 ; Lotfy et al, 2014 , 2019 , 2020a , 2020b , 2020c , 2021 , 2022 ; Ahmed and Lotfy, 2021 , 2022 ; Samir et al, 2014 ; Obaydo and Sakur, 2019 ; Obaydo and Alhaj Sakur, 2019 ; Al Zakri et al, 2019 ; Darweish et al, 2022 ) as well as the recently developed approaches based on absorptivity centering ( Lotfy et al, 2020a , 2020c ; Lotfy and Omran, 2018 ; Obaydo et al, 2021 ) owing to their inherent benefits such as simplicity, accuracy, reduction of expensive reagents consumption and eschewing time consuming or special software utilization.…”

“…Spectralprint recognition is a potential interpretation of the purity index using signals data of the extracted parent spectrum of each drug in the combinations and those of the pure drugs. Accordingly, the development of novel spectrophotometric methods that could be used in quality control and purity assessment of pharmaceutical products is critical for confirming the appliance of the drug products to consumers in terms of both safety and effectiveness ( Rostom et al, 2022 ; El-Hanboushy et al, 2022 ; Lotfy et al, 2020a ).…”

Eco-friendly spectrophotometric evaluation of triple-combination therapies in the treatment strategy of patients suffering from hypertension during coronavirus pandemic – Spectralprint recognition study

“…Mathematical spectrophotometric methods using built in spectrophotometer’s software are now being utilized more frequently for evaluation of drugs in pharmaceutical formulations [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] owing to their inherent benefits such as simplicity, accuracy, reduction of expensive reagents and eschewing of time consuming or special software. The objective of the current study was to develop a simple, precise, eco-friendly and economical parent spectrum resolution (PSR) manner for concurrent evaluation of VAL,AML and HCT in their triple antihypertensive medicines with trade name Exforge HCT® tablets with critical ratios so, sample enrichment technique [47] , [50] should be applied to increase the concentration of the minor component .The innovative PSR manner including novel methods namely, absorbance extraction (AE), peak-amplitude extraction (PE) and ratio extraction (RE) coupled with well-established constant multiplication (CM) and spectrum subtraction methods (SS) allowing the extraction of the parent absorption spectra (D 0 ) of the studied drugs, separately.…”