First Clinical Evaluation of a New Percutaneous Optical Fiber Glucose Sensor for Continuous Glucose Monitoring in Diabetes

Müller, Achim; Knuth, Monika; Nikolaus, Katharina Sibylle; Krivánek, Roland; Küster, Frank; Hasslacher, Christoph

doi:10.1177/193229681300700103

Cited by 28 publications

(20 citation statements)

References 32 publications

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“…40,41 In the research on the development of glucose sensor, sensing technologies using SBPs such as a galactose/glucose-binding protein and concanavalin A are well established and have been evaluated for continuous glucose monitoring in preclinical studies and human clinical studies. [42][43][44] However, measurement technology for glycated proteins employing SBPs has only recently been reported.…”

Section: Property Of Fructosyl Amino Acid-binding Proteinmentioning

confidence: 99%

Advancing the Development of Glycated Protein Biosensing Technology

Kameya

Sakaguchi-Mikami

Ferri

et al. 2015

J Diabetes Sci Technol

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Research advances in biochemical molecules have led to the development of convenient and reproducible biosensing molecules for glycated proteins, such as those based on the enzymes fructosyl amino acid oxidase (FAOX) or fructosyl peptide oxidase (FPOX). Recently, more attractive biosensing molecules with potential applications in next-generation biosensing of glycated proteins have been aggressively reported. We review 2 such molecules, fructosamine 6-kinase (FN6K) and fructosyl amino acid-binding protein, as well as their recent applications in the development of glycated protein biosensing systems. Research on FN6K and fructosyl amino acid-binding protein has been opening up new possibilities for the development of highly sensitive and proteolytic-digestion-free biosensing systems for glycated proteins.

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Section: Property Of Fructosyl Amino Acid-binding Proteinmentioning

confidence: 99%

Advancing the Development of Glycated Protein Biosensing Technology

Kameya

Sakaguchi-Mikami

Ferri

et al. 2015

J Diabetes Sci Technol

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“…Telemonitoring solutions for chronic conditions management are being assessed currently through multiple clinical [3][10] and economic studies [6] [7]. Some of the preliminary results conclude that the use of these technologies is not related to an improvement in health indicators [20].…”

Section: Discussionmentioning

confidence: 99%

“…From the handmade logbook reporting to stem-cells research, a wide variety of medical technologies are applied to maintain patient health. The healthcare industry and academics are fostering improvements in monitoring technologies: recently, the accuracy and reliability of a fibercoupled optical continuous glucose sensor was tested for 14 consecutive days in a clinical trial, showing promising results [3]; closed-loop artificial pancreas [4] can significantly reduce glucose variability, regardless patient adherence to treatment. Nevertheless, the patient should not be taken out of the equation.…”

Section: Introductionmentioning

confidence: 99%

Performance assessment of a closed-loop system for diabetes management

Martínez-Millana

Fico

Fernández-Llatas

2015

Med Biol Eng Comput

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“…[1][2][3] One limitation of fluorescencebased sensors is that the detected fluorescence signal is often weak, which results in low signal-to-noise ratio, 4 and significantly compromises the sensor performance. This problem can be overcome in fiber-optical fluorescence sensors by shaping the fiber tip to increase the numerical aperture (NA) of the fiber thereby collecting more of the fluorescence signal, as demonstrated by Gao et al 5 by linear and step-wise tapering of silica fibers.…”

Section: Introductionmentioning

confidence: 99%

Femtosecond laser micromachining of compound parabolic concentrator fiber tipped glucose sensors

et al. 2017

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, "Femtosecond laser micromachining of compound parabolic concentrator fiber tipped glucose sensors," J. Biomed. Opt. Abstract. We report on highly accurate femtosecond (fs) laser micromachining of a compound parabolic concentrator (CPC) fiber tip on a polymer optical fiber (POF). The accuracy is reflected in an unprecedented correspondence between the numerically predicted and experimentally found improvement in fluorescence pickup efficiency of a Förster resonance energy transfer-based POF glucose sensor. A Zemax model of the CPC-tipped sensor predicts an optimal improvement of a factor of 3.96 compared to the sensor with a plane-cut fiber tip. The fs laser micromachined CPC tip showed an increase of a factor of 3.5, which is only 11.6% from the predicted value. Earlier state-of-the-art fabrication of the CPC-shaped tip by fiber tapering was of so poor quality that the actual improvement was 43% lower than the predicted improvement of the ideal CPC shape. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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First Clinical Evaluation of a New Percutaneous Optical Fiber Glucose Sensor for Continuous Glucose Monitoring in Diabetes

Cited by 28 publications

References 32 publications

Advancing the Development of Glycated Protein Biosensing Technology

Advancing the Development of Glycated Protein Biosensing Technology

Performance assessment of a closed-loop system for diabetes management

Femtosecond laser micromachining of compound parabolic concentrator fiber tipped glucose sensors

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