First preparation of a triterpenoid-based supramolecular hydrogel in physiological phosphate buffered saline

Abstract

A glycyrrhetinic acid-based supramolecular hydrogel was attained in physiological phosphate buffered saline for the first time.

Natural Triterpenoid-Tailored Phosphate: In Situ Reduction of Heavy Metals Spontaneously to Generate Electrochemical Hybrid Gels

“…As a kind of natural products, triterpenoids exist abundantly in licorice root and own great biocompatibility, chiral rigid scaffolds, multiple reactive sites, and unique stacking manners. − The reactive sites (hydroxyl and carboxyl groups) on triterpenoids allow for the easy modification with functional units to advance the noncovalent interactions, thus engendering supramolecular assemblies. In this regard, a number of organogels and hydrogels have been fabricated by triterpenoid over the past 10 years. − For example, pyridinium-appended glycyrrhetinic acid (GA, one kind of triterpenoids) could form the nanofibers in physiological phosphate-buffered saline, and these fibers further entangled with each other to afford the supramolecular hydrogel, whereas the GA/β-cyclodextrin host–guest complex directed the formation of self-healing supramolecular polymer gels . However, to date, the fabrication of triterpenoid-based hybrid materials with metal NPs in situ is still rare.…”

Development of Natural-Drugs-Based Low-Molecular-Weight Supramolecular Gels

“…Because of the negative charge, the hydrogel can be used to adsorb and remove positively charged dyes such as pyridine yellow and rhodamine 6 G in the solution. Moreover, they constructed the first glycyrrhetinic-acid-based supramolecular hydrogel which could form in PBS physiological buffer by the self-assembly of pyridine modified glycyrrhetinic acid amphiphilic molecule (GP) [75]. The GP was obtained by the modification of the carboxyl group of E-ring of glycyrrhetinic acid with pyridine by the bridging effect of PEG.…”

Vesicular self-assembly of a natural ursane-type dihydroxy-triterpenoid corosolic acid

“…[27][28][29][30][31][32][33][34][35] Self-assembly property of several triterpenoids such as arjunolic acid, 36 betulinic acid, 37 betulin, 38 oleanolic acid, 39 glycyrrhetinic acid, 40 have been reported in different liquids by us and others, even without further functional transformations. [41][42][43] Derivatization of the functional triterpenoids has produced esters, ketals and alkali metal salts of triterpenoids having interesting self-assembly properties and applications in drug entrapment, pollutant capture, thermochromic materials, liquid crystals, etc. [44][45][46][47][48][49] One of the most interesting observation in the self-assembly of triterpenoids is that, minute variation in the triterpenoid backbone as well as the functional groups oen lead to different morphology in liquids.…”