This paper addresses the problem of the fixed-time cooperative guidance (FxTCG) law for multi-missiles against a single maneuvering target with constraints of both the interception time and the line-of-sight (LOS) angle. Firstly, by utilizing the consensus protocol and the fixed-time consensus theory, a new FxTCG in the LOS direction is presented to guarantee that the multiple missiles intercept the incoming target synchronously. Moreover, the acceleration of the target causes disturbance, so a simple fixedtime disturbance observer (FxTDO) is introduced to compensate FxTCG with the disturbance estimation. Subsequently, the FxTCG in the normal direction of the LOS is designed based on an adaptive fixedtime convergence reaching law and the proposed FxTDO, which ensures the fixed-time convergence of the LOS angular velocity and LOS angle between each missile and the maneuvering target. Finally, numerical simulations and adequate analyses are carried out to illustrate the accuracy, effectiveness, and robustness of the proposed FxTCG scheme. INDEX TERMS Cooperative guidance law, fixed-time convergence, LOS angle constraint, consensus protocol.