Flow injection based microfluidic device with carbon nanotube electrode for rapid salbutamol detection

Karuwan, Chanpen; Wisitsoraat, Anurat; Maturos, Thitima; Phokharatkul, Ditsayut; Sappat, Assawapong; Jaruwongrungsee, Kata; Lomas, Tanom; Tuantranont, Adisorn

doi:10.1016/j.talanta.2009.02.015

Cited by 57 publications

(20 citation statements)

References 21 publications

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“…[8][9][10][11][12][13] This platform was applied also in a capillary electrophoresis (CE) microchip. 14,15 Applications in electrophoretic systems, meanwhile, exhibit drawbacks related to interferences between the electric fields of detection and separation.…”

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confidence: 99%

Glass/PDMS hybrid microfluidic device integrating vertically aligned SWCNTs to ultrasensitive electrochemical determinations

et al. 2012

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This communication reports a promising platform for rapid, simple, direct, and ultrasensitive determination of serotonin. The method is related to integration of vertically aligned singlewalled carbon nanotubes (SWCNTs) in electrochemical microfluidic devices. The required microfabrication protocol is simple and fast. In addition, the nanomaterial influenced remarkably the obtained limit-of-detection (LOD) values. Our system achieved a LOD of 0.2 nmol L 21 for serotonin, to the best of our knowledge one of the lowest values reported in the literature.Glass/elastomer hybrid microfluidic platforms with integrated electrochemical detectors are powerful analytical tools. Their main advantages include: (i) low cost; (ii) chemical inertia; (iii) optical transparency; (iv) thermal, mechanical, and chemical stability; (v) automation capacity, and; (vi) easy microfabrication. In addition, they offer high values of reproducibility and sensitivity.

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confidence: 99%

Glass/PDMS hybrid microfluidic device integrating vertically aligned SWCNTs to ultrasensitive electrochemical determinations

et al. 2012

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“…Salbutamol can be detected using a CNT electrode and flow injection based microfluidic device (Karuwan et al, 2009). A MWCNTs modified GCE is also employed for the detection of nimesulide (Zhang et al, 2010a), resulting in an increase in sensitivity of about 7-folds in comparison to GCE.…”

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

Advances in carbon nanotube based electrochemical sensors for bioanalytical applications

Vashist

Zheng

Al‐Rubeaan

et al. 2011

Biotechnology Advances

407

218

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Electrochemical (EC) sensing approaches have exploited the use of carbon nanotubes (CNTs) as electrode materials owing to their unique structures and properties to provide strong electrocatalytic activity with minimal surface fouling. Nanofabrication and device integration technologies have emerged along with significant advances in the synthesis, purification, conjugation and biofunctionalization of CNTs. Such combined efforts have contributed towards the rapid development of CNT-based sensors for a plethora of important analytes with improved detection sensitivity and selectivity. The use of CNTs opens an opportunity for the direct electron transfer between the enzyme and the active electrode area. Of particular interest are also excellent electrocatalytic activities of CNTs on the redox reaction of hydrogen peroxide and nicotinamide adenine dinucleotide, two major by-products of enzymatic reactions. This excellent electrocatalysis holds a promising future for the simple design and implementation of on-site biosensors for oxidases and dehydrogenases with enhanced selectivity. To date, the use of an anti-interference layer or an artificial electron mediator is critically needed to circumvent unwanted endogenous electroactive species. Such interfering species are effectively suppressed by using CNT based electrodes since the oxidation of NADH, thiols, hydrogen peroxide, etc. by CNTs can be performed at low potentials. Nevertheless, the major future challenges for the development of CNT-EC sensors include miniaturization, optimization and simplification of the procedure for fabricating CNT based electrodes with minimal non-specific binding, high sensitivity and rapid response followed by their extensive validation using "real world" samples. A high resistance to electrode fouling and selectivity are the two key pending issues for the application of CNT-based biosensors in clinical chemistry, food quality and control, waste water treatment and bioprocessing.

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“…Salbutamol (SAL) is a β-adrenergic receptor agonist that was highly useful to cure bronchial asthma, chronic obstructive pulmonary disease and other allergic diseases associated with the respiratory pathway (Goyal, Oyama, & Singh, 2007;Karuwan et al, 2009;Spyridaki et al, 2006). However, SAL may appear in urine and body organs after taking medicine for a few days, being retained in the liver for 10 days and in the retinal tissue for at least 4 months.…”

Section: Introductionmentioning

confidence: 99%

Monoclonal antibody-based homogeneous immunoassay for three banned agonists and molecular modeling insight

Shen

Chen

et al. 2017

Food and Agricultural Immunology

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A homogeneous fluorescence polarization immunoassay (FPIA) was developed for the detection of an agonist salbutamol (SAL). Based on salbutamol-succinate-fluoresceinthiocarbamyl hexylenediamine (SAL-SUC-HDF), a fluorescein tracer with 6-carbon bridge was found to be more sensitive, the optimal FPIA showed the working range from 31.7 to 264.1 ng/mL with an IC 50 value of 91.4 ng/mL and a limit of detection 16.9 ng/mL. The cross-reactivity to brombuterol and clenbuterol was unexpectedly found to reach 447.3% and 255.8%, respectively. Computer-assisted molecular modeling revealed that the steric structure and electron density surfaces' effect appeared to be s two important factors to the broad-specific recognition to other agonists. ARTICLE HISTORY

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Flow injection based microfluidic device with carbon nanotube electrode for rapid salbutamol detection

Cited by 57 publications

References 21 publications

Glass/PDMS hybrid microfluidic device integrating vertically aligned SWCNTs to ultrasensitive electrochemical determinations

Glass/PDMS hybrid microfluidic device integrating vertically aligned SWCNTs to ultrasensitive electrochemical determinations

Advances in carbon nanotube based electrochemical sensors for bioanalytical applications

Monoclonal antibody-based homogeneous immunoassay for three banned agonists and molecular modeling insight

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